The development of effective tooth movement using the specific osteoclast inhibitor and the system of prevention on periodontal disease.

• Project/Area Number: 21592618
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Orthodontic/Pediatric dentistry
• Research Institution: Aichi Gakuin University
• Principal Investigator: GOTO Shigemi 愛知学院大学, 歯学部, 教授 (60142577)
• Co-Investigator(Kenkyū-buntansha): MIYAZAWA Ken 愛知学院大学, 歯学部, 教授 (60301636) ; TABUCHI Masako 愛知学院大学, 歯学部, 講師 (30418925)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 歯学 / 矯正学 / 歯周病予防 / 破骨細胞 / 病理学 / 歯周病

Research Abstract

We examined the periodontal tissue reaction course of OPG-/-mice using the Waldo method, and we investigated the effect of administering Bisphosphonate(BP) and Reveromycin A(RM-A) on the periodontal tissue. BP and RM-A treatment results in normalization of bone metabolism and loss of alveolar bone during experimental tooth movement in OPG-/-mice. Moreover, the model of the periodontal disease in mouse was established using wire ligature. Further studies are necessary to investigate and development the system of prevention on periodontal disease by control of the bone metabolism.

Research Products

• [Journal Article] 破骨細胞特異的薬剤(リベロマイシンA)投与が実験的歯の移動に及ぼす影響 (2011)
  • Author(s): 藪本貴洋、宮澤健、田渕雅子、庄司さつき、田中美由紀、門田愛実、吉廻守、川谷誠、長田裕之、後藤滋巳
  • Journal Title: 愛院大学歯学会誌 Volume: 49巻 Pages: 29-35
  • Peer Reviewed
• [Journal Article] 破骨細胞特異的薬剤(リベロマイシンA)が実験的歯の移動に及ぼす影響 (2011)
  • Author(s): 薮本貴洋
  • Journal Title: 愛知学院大学歯学会誌 Volume: 49 Pages: 29-35
  • Peer Reviewed
• [Journal Article] Bisphosphonate inhibits bone turnover in OPG(-/-) mice via a depressive effect on both osteoclasts and osteoblasts (2010)
  • Author(s): Shoji S, Tabuchi M, Miyazawa K, Yabumoto T, Tanaka M, Kadota M, Maeda H, Goto S
  • Journal Title: Calcified Tissue International Volume: Vol.87 Pages: 181-192
  • Peer Reviewed
• [Journal Article] Bisphosphonate Inhibits Bone Turnover in OPG-/- Mice Via a Depressive Effect on Both Osteoclasts and Osteoblasts. (2010)
  • Author(s): Satsuki Shoji
  • Journal Title: Calcified Tissue International Volume: 87 Pages: 181-192
  • Peer Reviewed
• [Presentation] 持続的矯正力による歯の移動に対する破骨細胞特異的薬剤(リベロマイシンA)の効果 (2011)
  • Author(s): 田中美由紀、宮澤健、田渕雅子、藪本貴洋、門田愛実、吉廻守、山根千里、川谷誠、長田裕之、後藤滋巳
  • Organizer: 第70回日本矯正歯科学会大会
  • Place of Presentation: 名古屋
• [Presentation] 破骨細胞活性が実験的歯の移動に及ぼす影響 (2009)
  • Author(s): 庄司さつき、田渕雅子、藪本貴洋、田中美由紀、宮澤健、後藤滋巳
  • Organizer: 第68回日本矯正歯科学会大会
  • Place of Presentation: 福岡
• [Presentation] 破骨細胞が実験的歯の移動に及ぼす影響 (2009)
  • Author(s): 庄司さつき
  • Organizer: 第68回日本矯正歯科学会大会
  • Place of Presentation: 福岡