Effects of type 2 diabetes mellitus on expression of marker of bone metabolism in periodontal tissue

• Project/Area Number: 21592619
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Periodontal dentistry
• Research Institution: Tohoku University
• Principal Investigator: SHOJI Kanako 東北大学, 大学院・歯学研究科, 助教 (90302158)
• Co-Investigator(Kenkyū-buntansha): SHINODA Hisashi 東北大学, 大学院・歯学研究科, 非常勤講師 (80014025) ; MURAKAMI Shinobu 東北大学, 大学院・歯学研究科, 教育研 究支援者 (40436093) ; SHIMAUCHI Hidetoshi 東北大学, 大学院・歯学研究科, 教授 (70187425)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 歯周免疫機能学 / 非肥満型２型糖尿病 / GKラット / 実験的歯周炎 / 骨生物学 / 糖尿病 / 歯周病と全身疾患の相互作用

Research Abstract

Non-fatty type 2 Diabetes mellitus may affect the metabolism of alveolar bone, both bone resorption and formation, and enhance the inflammatory process to result in the severe destruction and delay of regenerating process in experimental periodontitis in rats.