Analysis of the influence on the host cells of FDF derived from periodontopathic bacteria and the contribution in the pathogenesis of periodontitis
Project/Area Number |
21592620
|
Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Periodontal dentistry
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Research Institution | Tokyo Medical and Dental University |
Principal Investigator |
ARAKAWA Shinichi 東京医科歯科大学, 歯学部附属病院, 助教 (20302888)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
|
Keywords | 歯周免疫機能学 / 歯周病原細菌 / FDF / 歯周病 / 抗FDF抗体 / Tannerella forsythia / 歯周炎 / 歯肉溝滲出液 |
Research Abstract |
The FDF was taken in(or invade) a cell and raised oxidation membrane potential after reaching to mitochondria, and it was revealed that the FDF finally aggravated production of IL-8. The gingival crevicular fluid from periodontitis patients and normal subjects(for each 21) was isolated, and measured the anti-FDF antibody titer each. As a result, the antibody titer of periodontitis patients showed significantly higher than that of control group. Furthermore, 3 clinical parameters(Pocket depth, Clinical Attachment Level(CAL) and Bleeding on probing) are correlated with the anti-FDF antibody titer. These results suggest that the titer was associated with the condition of patients.
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Report
(4 results)
Research Products
(59 results)
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[Presentation] 平成21年度患者満足度アンケート調査の分析結果2010
Author(s)
礪波健一,俣木志朗,大林尚人,橋本吉明,荒川真一,鵜澤成一,釼持郁,比嘉りつ子,森薗立男,桜井純蘭,足達淑子,森山啓司,嶋田昌彦
Organizer
第75回口腔病学会学術大会
Place of Presentation
東京
Year and Date
2010-12-04
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[Book] 遺伝子医学2009
Author(s)
荒川真一
Total Pages
308
Publisher
株式会社メディカルドゥ
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