Pathological roles of tissue inhibitors of metalloproteinases in the tissues of drug-induced fibrous gingival over growth.

• Project/Area Number: 21592622
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Periodontal dentistry
• Research Institution: Niigata University
• Principal Investigator: KUBOTA Takehiko 新潟大学, 医歯学総合病院, 講師 (50303136)
• Co-Investigator(Kenkyū-buntansha): NAKASONE Naohiro 新潟大学, 医歯学総合病院, 医員 (20447634)
• Co-Investigator(Renkei-kenkyūsha): MARUYAMA Satoshi 新潟大学, 医歯学総合病院, 講師 (30397161) ; NOUNO Kaname 新潟大学, 医歯学系, 助教 (80422608)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 歯周免疫機能学 / 医療・福祉 / 歯学 / 酵素 / 免疫学 / 病理学

Research Abstract

We have reported the 1^<st> report "Gene expression and immunohistochemical protein localization of TIMP-3 and TIMP-in gingival overgrowth and periodontitis-affected gingival tissues" Archs Oral Biology(2009). Then I have received the Academic Senior Investigator's Award for this series of studies in 2009 from Japanese Society of Conservative Dentistry(Review 2010)。The 2^<nd> and 3^<rd> reports :"Microarray and data-mining analyses for specific gene expression in drug-induced gingival overgrowth tissues. Archs Oral Biology(2011)", and "Altered gene expression pattern and specific biological pathways in periodontitis-affected gingival tissues." J Periodont Res(2011) have published in international scientific peer review journals.

Research Products

• [Journal Article] Altered gene expression in leukocyte transendothelial migration and cell communication pathways in periodontitis-affected gingival tissues (2011)
  • Author(s): Abe D, Kubota T, Morozumi T, Shimizu T, Nakasone N, Itagaki M, Yoshie H.
  • Journal Title: J Periodont Res Volume: 46 Pages: 345-353
  • Peer Reviewed
• [Journal Article] Microarray and quantitative RT-PCR analyses in calcium-channel blockers induced gingival overgrowth tissues of periodontitis patients (2011)
  • Author(s): Shimizu T, Kubota T, Nakasone N, Abe D, Morozumi T, Yoshie H
  • Journal Title: Arch Oral Biol Volume: 56 Pages: 277-284
  • Peer Reviewed
• [Journal Article] Altered gene expression in leukocyte transendothelial migration and cell communication pathways in periodontitis-affected gingival tissues (2011)
  • Author(s): Abe D, Kubota T, Morozumi T, Shimizu T, Nakasone N, Itagaki M, Yoshie H
  • Journal Title: J Periodontal Res Volume: 46 Issue: 3 Pages: 345-353
  • DOI: 10.1111/j.1600-0765.2011.01349.x
  • Peer Reviewed
• [Journal Article] Micro array and quantitative RT-PCR analyses in calcium-channel blockers induced gingival overgrowth tissues of periodontitis patients (2011)
  • Author(s): Shimizu T, Kubota T, Nakasone N, Abe D, Morozumi T, Yoshie H
  • Journal Title: Arch Oral Biol Volume: 56 Issue: 3 Pages: 277-284
  • DOI: 10.1016/j.archoralbio.2010.10.002
  • Peer Reviewed
• [Journal Article] Altered gene expression in leukocyte transendothelial migration and cell communication pathways in periodontitis-affected gingival tissues (2011)
  • Author(s): Abe D, Kubota T.Morozumi T, ShimizuT, Nakasone N, Itagaki M, Yoshie H.
  • Journal Title: JPeriodontal Res Volume: in press
  • Peer Reviewed
• [Journal Article] 歯周炎組織破壊における生体酵素動態と歯周炎感受性診断 (2010)
  • Author(s): 久保田健彦、ミニレビュー
  • Journal Title: 日本歯科保存学会雑誌 Volume: 53巻 Pages: 6-8
  • NAID: 110007880704
  • Peer Reviewed
• [Journal Article] ミニレビュー:歯周炎組織破壊における生体酵素動態と歯周炎感受性診断 (2010)
  • Author(s): 久保田健彦
  • Journal Title: 日本歯科保存学会雑誌 Volume: 53 Pages: 6-8
• [Journal Article] ミニレビュー:歯周炎組織破壊における生体酵素動態と歯周炎感受性診断 (2010)
  • Author(s): 久保田健彦
  • Journal Title: 日本歯科保存学会雑誌 53 Pages: 6-8
  • Peer Reviewed
• [Journal Article] Differential gene and protein expression of tissue inhibitors of metalloproteinases(TIMP)-3 and TIMP-4 in gingival tissues from drug induced gingival overgrowth (2009)
  • Author(s): Nakasone N, Kubota T, Hoshino C, Nohno K, Itagaki M, Shimizu T, Yoshie H
  • Journal Title: Arch Oral Biol Volume: 54 Pages: 634-641
  • Peer Reviewed
• [Journal Article] Differential gene and protein expression of tissue inhibitors of metalloproteinases (TIMP)-3 and TIMP-4 in gingival tissues from drug induced gingival overgrowth. (2009)
  • Author(s): Nakasone N, Kubota T, Hoshino C, Nohno K, Itagaki M, Shimizu T, Yoshie H
  • Journal Title: Arch Oral Biol 54 Pages: 634-641
  • Peer Reviewed
• [Presentation] ACE及びTIMP-3の薬物性歯肉増殖症と歯周炎の歯肉組織における遺伝子発現とタンパク質局在 (2010)
  • Author(s): 冨田尊志、久保田健彦、中曽根直弘、飯山真奈美、両角俊哉、永田昌毅、堀水慎、濃野要、吉江弘正
  • Organizer: 第54回秋季日本歯周病学会学術大会
  • Place of Presentation: 下関市
  • Year and Date: 2010-09-24
• [Presentation] アルツハイマー病関連遺伝子は歯周炎罹患歯肉において転写発現亢進している (2010)
  • Author(s): 久保田健彦、阿部大輔、清水太郎、中曽根直弘、両角俊哉、吉江弘正
  • Organizer: 第53回秋季日本歯周病学会学術大会
  • Place of Presentation: 高松市
  • Year and Date: 2010-09-19
• [Presentation] Alzheimer's disease pathway was accelerated in periodontitis-affected gingival tissues (2010)
  • Author(s): Kubota T, Abe D, Shimizu T, Nakasone N, Morozumi T, Yoshie H
  • Organizer: IADR 88th General Session 2010
  • Place of Presentation: Barcelona, Spain
• [Presentation] Alzheimer's disease pathway was accelerated in periodontitis-affectedgingival tissues (2010)
  • Author(s): Kubota T.Abe D, Shimizu T, Nakalone N, Morozumi T, Yoshie H
  • Organizer: IADR 88^<th> General Session 2010
  • Place of Presentation: Barcelona, Spain
• [Presentation] Transcriptomes in sites with drug-induced gingival-overgrowth Microarray and qRT-PCR analyses (2009)
  • Author(s): Shimizu T, Kubota T, Abe D, Morozumi T, Nakasone N, Yoshie H
  • Organizer: EUROPERIO6
  • Place of Presentation: Stockholm, Sweden
• [Presentation] 薬剤性歯肉増殖症の感受性と特異的遺伝子発現の網羅的解析 (2009)
  • Author(s): 清水太郎、久保田健彦、阿部大輔、両角俊哉、中曽根直弘、吉江弘正
  • Organizer: 第52回春季日本歯周病学会学術大会
  • Place of Presentation: 岡山市
• [Book] 歯周組織再生と歯根膜.歯界展望別冊「歯と歯列を守るための歯根膜活用術」 (2011)
  • Author(s): 久保田健彦、吉江弘正
  • Publisher: 医歯薬
• [Book] 歯周組織再生と歯根膜.歯界展望別冊「歯と歯列を守るための歯根膜活用術」 (2011)
  • Author(s): 久保田健彦、吉江弘正
  • Total Pages: 146
  • Publisher: 医歯薬出版
• [Remarks] (1)日本歯科保存学会学術賞受賞論文のURL
  • URL: http://wwwsoc.nii.ac.jp/jscd/member/pdf/vol53_no1/6.pdf