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Cross reactivity of archaeal chaperonin with human CCT involved in the pathogenesis of periodontitis and autoimmune disease

Research Project

Project/Area Number 21592624
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Periodontal dentistry
Research InstitutionOkayama University

Principal Investigator

MAEDA Hiroshi  岡山大学, 大学院・医歯薬学総合研究科, 准教授 (00274001)

Co-Investigator(Kenkyū-buntansha) TAKASHIBA Shogo  岡山大学, 大学院・医歯薬学総合研究科, 教授 (50226768)
KOKEGUCHI Susumu  岡山大学, 大学院・医歯薬学総合研究科, 准教授 (10144776)
TANIMOTO Ichiro  岡山大学, 大学院・医歯薬学総合研究科, 助教 (00280686)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords歯周病 / 古細菌 / シャペロニン / 自己免疫応答 / 自己免疫疾患 / Methanobrevibacter oralis / CCT / methanobrevibacter oralis / 交差反応
Research Abstract

Periodontitis is known to be an infectious disease caused by oral bacteria. Besides bacteria, it has recently been reported that methanogenic Archaea is also involved in the pathogenesis of periodontitis. Archaea possess group II chaperonin that is homologous to human chaperonin CCT. Due to the sequence similarity, archaeal chaperonin has the potential to be a cross-reactive antigen of human CCT. We examined the reactivity of sera from patients with periodontitis or autoimmune diseases to the chaperonins. Antibody to the archaeal chaperonin and human CCT was detected in some patients. The results demonstrated the possible induction of autoimmune reaction targeting the group II chaperonin. Cross reaction between the archaeal and human chaperonin may be a trigger for autoimmune reaction.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (10 results)

All 2011 2010 2009

All Journal Article (6 results) (of which Peer Reviewed: 3 results) Presentation (4 results)

  • [Journal Article] Antigenic group II chaperonin in Methanobrevibacter oralis may cross-react with human chaperonin CCT2010

    • Author(s)
      Yamabe K, Maeda H, Kokeguchi S, Soga Y, Meguro M, Naruishi K, Asakawa S, Takashiba S
    • Journal Title

      Mol Oral Microbiol

      Volume: 25 Pages: 112-122

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] メタン産生古細菌Methanobrevibacterの口腔疾患への関わり2010

    • Author(s)
      苔口進, 山部こころ, 前田博史
    • Journal Title

      日本臨床腸内微生物学会誌

      Volume: 12 Pages: 17-25

    • Related Report
      2011 Final Research Report
  • [Journal Article] メタン生成古細菌は歯周病の病原因子?2010

    • Author(s)
      山部こころ, 苔口進, 前田博史
    • Journal Title

      化学と生物

      Volume: 48 Pages: 463-470

    • NAID

      10026875519

    • Related Report
      2011 Final Research Report
  • [Journal Article] メタン生成古細菌は歯周病の病原因子2010

    • Author(s)
      山部こころ、苔口進、前田博史
    • Journal Title

      化学と生物

      Volume: 48 Pages: 463-470

    • NAID

      10026875519

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antigenic groupII chaperonin in Methanobrevibacter oralis may cross-react with human chaperonin CCT2010

    • Author(s)
      Yamabe K, Maeda H, et al.
    • Journal Title

      Molecular Oral Microbiology 25(2)

      Pages: 112-122

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] メタン生成古細菌Methanobrevibacterの口腔疾患への関わり2010

    • Author(s)
      苔口進、山部こころ、前田博史
    • Journal Title

      日本臨床腸内微生物学会誌 (印刷中)

    • Related Report
      2009 Annual Research Report
  • [Presentation] プラークを再考する2011

    • Author(s)
      前田博史
    • Organizer
      第135回日本歯科保存学会秋季学術大会
    • Place of Presentation
      大阪市
    • Year and Date
      2011-10-20
    • Related Report
      2011 Final Research Report
  • [Presentation] プラークを再考する2011

    • Author(s)
      前田博史
    • Organizer
      第135回日本歯科保存学会秋季学術大会
    • Place of Presentation
      大阪
    • Year and Date
      2011-10-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] メタン産生古細菌Methanobrevibacterの口腔疾患へのかかわり2009

    • Author(s)
      苔口進、山部こころ、前田博史
    • Organizer
      第12回日本臨床腸内微生物学会総会
    • Place of Presentation
      岐阜市
    • Year and Date
      2009-09-05
    • Related Report
      2011 Final Research Report
  • [Presentation] メタン産生古細菌Methanobrevibacterの口腔疾患へのかかわり2009

    • Author(s)
      苔口進、山部こころ、前田博史
    • Organizer
      第12回日本臨床腸内微生物学会総会 教育講演
    • Place of Presentation
      岐阜市
    • Year and Date
      2009-09-05
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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