| Project/Area Number |
21592626
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Periodontal dentistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAGATA Toshihiko 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (10127847)
BANDO Mika 徳島大学, 病院, 助教 (10510000)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 歯周病 / 抗菌ペプチド / 遺伝子多型 / カルプロテクチン / ディフェンシン / ラクトフェリン / SNPs / インベーダー法 |
|---|
| Research Abstract |
To investigate the relationship between single-nucleotide polymorphisms(SNPs) of antimicrobial peptides and periodontitis, we performed to genotype at known 7 SNPs(three SNPs of calprotectin, three SNPs of.-defensin-1 and a SNP of lactoferrin) in 103 Japanease individuals with or without periodontitis. The-44CC genotype of DEFB1(rs1800972) is associated with moderate and severe chronic periodonntits(odds ratio 3. 692). Furthermore.-defensin-1 in gingival crevicular fluids were quantified by ELISA, the peptide concentrations were significantly lower in the individuals with-44 CC genotype of DEFB1 than in those without-44CC genotype of it.
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