Analysis an accelerative mechanism of atherosclerosis by periodontitis-effect of inflammatory alveolar bone resorption-
Project/Area Number |
21592627
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Periodontal dentistry
|
Research Institution | Nagasaki University |
Principal Investigator |
UKAI Takashi 長崎大学, 大学病院, 講師 (20295091)
|
Co-Investigator(Kenkyū-buntansha) |
HARA Yoshitaka 長崎大学, 大学院・医歯薬学総合研究科, 教授 (60159100)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 骨吸収 / 歯周病 / アテローム性動脈硬化 / 破骨細胞 / RANKL / 泡沫化細胞 / 歯周免疫機能学 / 動脈硬化 / 炎症性骨吸収 / CD40 ligand / インターフェロンγ / IFNγ / ApoE |
Research Abstract |
We studied an effect of inflammatory bone loss in atherosclerosis to clarify the mechanism of relationship between periodontal diseases and atherosclerosis. As the results, we revealed atherosclerosis accelerated when mice were induced inflammatory bone loss. In the tissues of atherosclerosis, RANKL positive cells were observed by immunohistochemistry. Furthermore, foam cell formation was accelerated by RANKL stimulation in vitro.
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Report
(4 results)
Research Products
(22 results)