Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Research Abstract |
We studied an effect of inflammatory bone loss in atherosclerosis to clarify the mechanism of relationship between periodontal diseases and atherosclerosis. As the results, we revealed atherosclerosis accelerated when mice were induced inflammatory bone loss. In the tissues of atherosclerosis, RANKL positive cells were observed by immunohistochemistry. Furthermore, foam cell formation was accelerated by RANKL stimulation in vitro.
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