Analysis an accelerative mechanism of atherosclerosis by periodontitis-effect of inflammatory alveolar bone resorption-

• Project/Area Number: 21592627
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Periodontal dentistry
• Research Institution: Nagasaki University
• Principal Investigator: UKAI Takashi 長崎大学, 大学病院, 講師 (20295091)
• Co-Investigator(Kenkyū-buntansha): HARA Yoshitaka 長崎大学, 大学院・医歯薬学総合研究科, 教授 (60159100)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 骨吸収 / 歯周病 / アテローム性動脈硬化 / 破骨細胞 / RANKL / 泡沫化細胞 / 歯周免疫機能学 / 動脈硬化 / 炎症性骨吸収 / CD40 ligand / インターフェロンγ / IFNγ / ApoE

Research Abstract

We studied an effect of inflammatory bone loss in atherosclerosis to clarify the mechanism of relationship between periodontal diseases and atherosclerosis. As the results, we revealed atherosclerosis accelerated when mice were induced inflammatory bone loss. In the tissues of atherosclerosis, RANKL positive cells were observed by immunohistochemistry. Furthermore, foam cell formation was accelerated by RANKL stimulation in vitro.

Research Products

• [Journal Article] Peptidoglycan and lipopolysaccharide synergistically enhance bone resorption and osteoclastogenesis (2012)
  • Author(s): Kishimoto T, Kaneko T, Ukai T, Yokoyama M, Ayon Haro R, Yoshinaga Y, Yoshimura A, Hara Y.
  • Journal Title: J Periodontal Res Volume: 47 Issue: 4 Pages: 446-454
  • DOI: 10.1111/j.1600-0765.2011.01452.x
  • Peer Reviewed
• [Journal Article] The formation of immune complexes is involved in the acute phase of periodontal destruction in rats (2012)
  • Author(s): Kuramoto A
  • Journal Title: J Periodontal Res Volume: (In press) Issue: 4 Pages: 455-462
  • DOI: 10.1111/j.1600-0765.2011.01453.x
  • Peer Reviewed
• [Journal Article] Membrane-bound CD40 Ligand on T cells from mice injected with lipopolysaccharide(LPS) accelerates LPS-induced osteoclastogenesis (2011)
  • Author(s): M Yokoyama, T Ukai, E. R. Ayon Haro, T Kishimoto, Y Yoshinaga, Y Hara
  • Journal Title: Journal of Periodontal Research, Volume: 46 Pages: 464-474
• [Journal Article] Locally administered interferon-γaccelerates lipopolysaccharide-induced osteoclastogenesis independent of immunohistological RANKL upregulation E (2011)
  • Author(s): R. Ayon Haro, T Ukai, M Yokoyama, T Kishimoto, Y Yoshinaga, Y Hara
  • Journal Title: Journal of Periodontal Research Volume: 46 Pages: 361-373
• [Journal Article] エピガロカテキンガレートが破骨細胞形成に及ぼす影響 (2011)
  • Author(s): 鵜飼孝
  • Journal Title: 日本歯科保存学会誌 Volume: 54 Pages: 375-383
  • NAID: 110009419165
  • Peer Reviewed
• [Journal Article] Membrane-bound CD40 Ligand on T cells from mice injected with lipopolysaccharide (LPS) accelerates LPS-induced osteoclastogenesis (2011)
  • Author(s): Yokoyama M
  • Journal Title: J Periodont Res Volume: (In press)
  • Peer Reviewed
• [Journal Article] Locally administered interferon-γ accelerates lipopolysaccharide-induced osteoclastogenesis independent of immunohistological RANKL upregulation (2011)
  • Author(s): Ayon Haro ER
  • Journal Title: J Periodont Res Volume: (In poress)
  • Peer Reviewed
• [Presentation] 茶カテキンはLPS誘導性の歯周ポケット形成および歯槽骨吸収を抑制した (2011)
  • Author(s): 吉永泰周
  • Organizer: 日本歯科保存学会
  • Place of Presentation: 大阪
  • Year and Date: 2011-10-20
• [Presentation] 骨吸収に対するペプチドグリカンとリポ多糖の協調作用に関する研究 (2011)
  • Author(s): 岸本隆明
  • Organizer: 日本歯科保存学会
  • Place of Presentation: 大阪
  • Year and Date: 2011-10-20
• [Presentation] ペプチドグリカンはリポ多糖と協調して歯槽骨吸収と破骨細胞形成を促進する (2011)
  • Author(s): 岸本隆明、金子高士、鵜飼孝、横山美穂、長野史子、佐藤佳昌、吉永泰周、吉村篤利、原宜興
  • Organizer: 第54回春季日本歯周病学会学術大会
  • Place of Presentation: 福岡
  • Year and Date: 2011-05-27
• [Presentation] ペプチドグリカンはリポ多糖と協調して歯槽骨吸収と破骨細胞形成を促進する (2011)
  • Author(s): 岸本隆明
  • Organizer: 日本歯周病学会
  • Place of Presentation: 福岡
  • Year and Date: 2011-05-27
• [Presentation] 骨吸収に対するペプチドグリカンとリポ多糖の協調作用に関する研究 (2011)
  • Author(s): 岸本隆明、金子高士、鵜飼孝、横山美穂、吉永泰周、佐藤佳昌、長野史子、山下泰徳、吉村篤利、原宜興
  • Organizer: 日本歯科保存学会、プログラムおよび講演抄録集、2011年度秋季学術大会
  • Place of Presentation: 大阪国際交流センター
• [Presentation] LPS存在下でCD40Lはin vivoにおける破骨細胞形成を促進する (2010)
  • Author(s): 横山美穂、鵜飼孝、Ayon Haro Esperanza Raquel、岸本隆明、藏本明子、白石千秋、吉永美穂、原宜興
  • Organizer: 第53回秋季日本歯周病学会学術大会
  • Place of Presentation: 高松
  • Year and Date: 2010-09-19
• [Presentation] LPS注入マウス脾細胞によるfoam cell形成の促進 (2010)
  • Author(s): 鵜飼孝、岸本隆明、横山美穂、原宜興
  • Organizer: 第53回秋季日本歯周病学会学術大会
  • Place of Presentation: 高松
  • Year and Date: 2010-09-19
• [Presentation] LPS注入マウス脾細胞によるfoam cell形成の促進 (2010)
  • Author(s): 鵜飼孝
  • Organizer: 第53回秋季日本歯周病学会学術大会
  • Place of Presentation: 高松市、香川
  • Year and Date: 2010-09-19
• [Presentation] 歯槽骨吸収とアテローム性動脈硬化の関連 (2010)
  • Author(s): 鵜飼孝
  • Organizer: 第7回長崎歯周病学講演会
  • Place of Presentation: 長崎
  • Year and Date: 2010-02-06
• [Presentation] Locally administered interferon-gamma accelerates RANKL-induced osteoclastogenesis in the presence of lipopolysaccharide (2010)
  • Author(s): E. R. Ayon Haro, T. Ukai, M. Yokoyama, T. Kishimoto, Y. Yoshinaga, Y. Hara
  • Organizer: The 96^<th> annual meeting of the American Academy of Periodontology
  • Place of Presentation: Honolulu, Hawaii
• [Presentation] CD40L accelerates osteoclastogenesis induced by RANKL and LPS (2010)
  • Author(s): Yokoyama M, Ukai T, Kishimoto T, Ayon Haro ER, Kuramoto A, Yoshinaga Y, Takamori Y, Hara Y
  • Organizer: 88^<th> General Session & Exhibition of the IADR
  • Place of Presentation: Barcelona, Spain
• [Presentation] CD40L accelerates osteoclastogenesis induced by RANKL and LPS. (2010)
  • Author(s): Yokoyama M
  • Organizer: 88^<th> General Session & Exhibition of the IADR
  • Place of Presentation: Barcelona, Spain
• [Presentation] Locally Administered Interferon-gamma Accelerates RANKL-induced Osteoclastogenesis in the Presence of Lipopolysaccharide (2010)
  • Author(s): Ayon Haro ER
  • Organizer: The 96^<th> Annual Meeting of the American Academy of Periodontology
  • Place of Presentation: Honolulu, Hawaii
• [Presentation] 歯周組織の免疫応答から考える全身への影響.歯周病と動脈硬化-歯槽骨吸収とアテローム性動脈硬化の関連- (2009)
  • Author(s): 鵜飼孝
  • Organizer: 第52回日本歯周病学会、秋季学術大会
  • Place of Presentation: 宮崎観光ホテル
  • Year and Date: 2009-10-11
• [Presentation] 歯周病と動脈硬化-歯槽骨吸収とアテローム性動脈硬化の関連- (2009)
  • Author(s): 鵜飼孝
  • Organizer: 第52回秋季日本歯周病学会学術大会
  • Place of Presentation: 宮崎
  • Year and Date: 2009-10-11