| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
The purpose of the present study was to evaluate cell biocompatibility and decontamination effect using β-TCP air-abrasion and BMP-2-incorporated PLGA microcapsule. β-TCP air abrasion decontamination led to microscopically visible alterations of the implant surface, however, it seems have a good potential to remove cytotoxic bacterial components from titanium surfaces. BMP-2 encapsulation efficiency from PLGA microcapsules was 37.5%. BMP-2 incorporated PLGA microcapsule elevated alkaline phosphatase activity in preosteoblasts. These results obtained suggest that encapsulated BMP-2 induces bone regeneration on titanium surface after removing cytotoxic bacterial components by β-TCP air-abrasion.
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