| Project/Area Number |
21592634
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Periodontal dentistry
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|---|
| Research Institution | Showa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Gou 昭和大学, 歯学部, 助教 (80384189)
USUI Michihiko 昭和大学, 歯学部, 助教 (10453630)
|
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 付着上皮 / 遺伝子発現 / 自然免疫 / 自然炎症 / 歯周病 / マイクロダイセクション / 抗菌物質 / カルプロテクチン / 網羅的遺伝子解析 / 接合上皮 / レーザーダイセクション |
|---|
| Research Abstract |
Junctional epithelium(JE) is important for the maintenance of periodontal tissues without keratosis, and indicates specific characteristics. Our comprehensive gene expression analysis in JE demonstrated that several molecules concerning innate immunity or homeostatic inflammation such as S100A9, S100A8, CXCL1, CXCL2 and SLPI, has been confirmed. Those result showed that JE has different gene expression pattern from keratinized oral epithelium.
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