Establishment of an effective three dimensional culture model for screening of molecular targeted drug for periodontitis
| Project/Area Number |
21592637
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Periodontal dentistry
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| Research Institution | Ohu University (2010-2012)
Nihon University (2009) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAMAGUCHI Yoko 日本大学, 歯学部, 助手 (00239922)
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| Co-Investigator(Renkei-kenkyūsha) |
ABIKO Yoshimitsu (KATO Mitsuyasu) 日本大学, 松戸歯学部, 教授 (70050086)
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| Project Period (FY) |
2009 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 歯周免疫機能学 / 生体外歯周炎モデル / 三次元培養 / コラーゲン分解阻害 / 歯周炎原因遺伝子 / 分子標的治療薬 / コラーゲン分解阻害剤 / 歯周炎 / コラーゲン分解 |
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| Research Abstract |
“In vitro periodontitis model” using collagen gel three-dimensional culture was established combining primary cultured gingival epithelial cells and gingival fibroblasts. Transcriptome analyses revealed several candidate genes for periodontitis. Furthermore, inhibition of activity of FLT-1, one of the products of candidate genes for periodontitis, using small molecule kinase inhibitor successfully controlled collagen gel degradation, suggested a possibility to use this kinase inhibitor as a molecular-targeted drug for periodontitis.
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Report
(5 results)
Research Products
(47 results)
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[Journal Article] TGF-b signaling in gingival fibroblast-epithelial interaction2010
Author(s)
M. Ohshima, Y. Yamaguchi, M. Matsumoto, P. Micke, T. Takenouchi, N. Nishida, M. Kato, K. Komiyama, Y. Abiko, K. Ito, K. Otsuka, K. Kappert
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Journal Title
J Dent Res
Volume: 89
Issue: 11
Pages: 1315-1321
DOI
Related Report
Peer Reviewed
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[Presentation]2012
Author(s)
大島光宏、山口洋子、張 月琳、佐久間淳
Organizer
2012年度日本機会学会年次大会
Place of Presentation
金沢
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