| Project/Area Number |
21592638
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Periodontal dentistry
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| Research Institution | Aichi Gakuin University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MITANI Akio 愛知学院大学, 歯学部, 講師 (50329611)
KAMEI Hidehiko 愛知学院大学, 歯学部, 講師 (50421243)
田中 繁寿 愛知学院大学, 歯学部, 講師 (30367619)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 歯周免疫機能学 / インターロイキン-1 / 実験的歯周炎 / インターロイキン-1タイプIIレセプター / インターロイキン-1レセプターアンタゴニスト / 歯周病 / IL-1Ra欠損マウス / 炎症性サイトカイン / 炎症性骨吸収 / 実験的歯周炎モデル / IL-1 / IL-1Ra KOマウス / Type II IL-1 receptor / IL-1 receptor antagonist / LPS / ELISA法 / 破骨細胞形成 / Tepe II IL-1 receptor |
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| Research Abstract |
Experimental periodontosis model animal was changed to a rat from a mouse, and experimental periodontosis was induced by periodontal bacterium-adhered ligature onto the molars at 2009 and 2010.The experimental site observed the high levels of inflammatory cytokine production, the inflammatory bone resorption with osteoclast formation and IL-1R2 and IL-1Ra inhibited the osteoclast differentiation factors from rat osteoblast. The research will be developed in 2011 using an IL-1Ra gene deficient mouse.
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