| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
We have tried to establish the two different mouse upper airway experimental model to explore the pathophysiological factor to induce obstructive sleep apnea syndrome. We have tested the neuromuscular compensatory response under general anesthesia by analysis of passive and active upper airway collapsibility (Pcrit and resistance calculated pressure flow relationship). However, with spontaneous breathing under general anesthesia, the influence of muscle relaxant by anesthetic agent may cause major effect on upper airway. We have also established the rabbit model to test upper airway collapsibility with spontaneous breathing under general anesthesia. We have found moderate increase of body weight did not cause significant change in Pcrit of rabbit upper airway. We have also found that instillation of surfactant into pharyngeal region slightly decrease Pcrit as reported in previous study. In conclusion, we could not exclude the effect of general anesthesia on both mouse and rabbit experiment to evaluate upper airway functions.
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