| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Research Abstract |
In the epidemiologic survey, we have shown that higher serum resistin levels are associated with periodontitis. Therefore, we decided to investigate where the source of resistin. In this study, both of P. g LPS and E. coli LPS tended to enhance resistin expression in THP-1 and U937 macrophage-like cells. Resistin expression increased in primary monocyte and macrophage-like cells when stimulated by E. coli LPS or P. g LPS. Increased resistin in several inflammatory cells stimulated by periodontal pathogenic LPS may play important roles in systemic disease such as obesity, type2 diabetes and cardiovascular disease.
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