Adipokine induction and TLR related signal transduction by periodontal pathogenic LPS
| Project/Area Number |
21592655
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Social dentistry
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| Research Institution | Nagasaki University |
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Principal Investigator |
FURUGEN Reiko 長崎大学, 大学院・医歯薬学総合研究科, 助教 (90253674)
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| Co-Investigator(Kenkyū-buntansha) |
SAITO Toshiyuki 長崎大学, 大学院・医歯薬学総合研究科, 教授 (10170515)
HAYASHIDA Hideaki 長崎大学, 病院, 講師 (20238140)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | アディポカイン / 歯周病 / LPS / シグナル伝達 / レジスチン / 好中球 |
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| Research Abstract |
In the epidemiologic survey, we have shown that higher serum resistin levels are associated with periodontitis. Therefore, we decided to investigate where the source of resistin. In this study, both of P. g LPS and E. coli LPS tended to enhance resistin expression in THP-1 and U937 macrophage-like cells. Resistin expression increased in primary monocyte and macrophage-like cells when stimulated by E. coli LPS or P. g LPS. Increased resistin in several inflammatory cells stimulated by periodontal pathogenic LPS may play important roles in systemic disease such as obesity, type2 diabetes and cardiovascular disease.
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Report
(4 results)
Research Products
(6 results)
