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Study on anti. inflammatory action of endopeptidases for prevention and treatment of periodontal diseases

Research Project

Project/Area Number 21592657
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Social dentistry
Research InstitutionKyushu Dental College

Principal Investigator

AWANO Shuji  九州歯科大学, 歯学部, 講師 (20301442)

Co-Investigator(Kenkyū-buntansha) ANSAI Toshihiro  九州歯科大学, 歯学部, 教授 (80244789)
SOU Inho  九州歯科大学, 歯学部, 助教 (10285463)
TAKEHARA Tadamichi  九州歯科大学, 歯学部, 名誉教授 (00038879)
YOSHIDA Akihiro  九州歯科大学, 歯学部, 助教 (20364151)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsエンドペプチダーゼ / NEP / サブスタンスP / インターロイキン-1 / 歯周疾患 / ケラチノサイト / アミノペプチダーゼ / CD10 / ECE-1
Research Abstract

This project verified the role of neutral(NEP) and endothelin. converting enzyme-1(ECE-1) in oral epithelial keratinocyte(hOMK). As a result, NEP has been found to regulate the levels of inflammatory mediators such substance P and interleukin-1βgenerated from hOMK with ECE-1, and it is suggested that NEP and ECE-1 on hOMK have anti-inflammatory action during the inflammatory process of periodontal diseases.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (37 results)

All 2012 2011 2010 2009 Other

All Journal Article (21 results) (of which Peer Reviewed: 13 results) Presentation (12 results) Remarks (4 results)

  • [Journal Article] Physical fitness and 6.5-year mortality in an 85-year old community-dwelling population2012

    • Author(s)
      Takata, Y., Ansai, T., Soh, I., Awano, S., Yoshitake, Y., Kimura, Y., Nakamichi, I., Goto, K., Fujisawa, R., Sonoki, K., Yoshida, A., Toyoshima, K. and Nishihara, T
    • Journal Title

      Arch Gerontol Geriatr

      Volume: 54(1) Pages: 28-33

    • Related Report
      2011 Final Research Report
  • [Journal Article] Association of disease-specific mortality with physical fitness measurements and nonparticipation in an 80-year-old population.2012

    • Author(s)
      Takata Y, Ansai T, Soh I, Awano S, Yoshitake Y, Kimura Y, Nakamichi I, Akifusa S, Goto K, Yoshida A, Fujisawa R, Sonoki K, Nishihara T
    • Journal Title

      Geriatrics

    • Related Report
      2011 Final Research Report
  • [Journal Article] Salivaryα-amylase activity and stress in Japan Air Self-Defence Force cargo pilots involved in Iraq reconstruction2012

    • Author(s)
      Iizuka N, Awano S, Ansai T
    • Journal Title

      American Journal of Human Biology

      Volume: 24 Issue: 4 Pages: 468-472

    • DOI

      10.1002/ajhb.22247

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Oral health in patients on haemodialysis for diabetic nephropathy and chronic glomerulonephritis2012

    • Author(s)
      Teratani G, Awano S, Soh I, Yoshida A, Kinoshita N, Hamasaki T, Takata Y, Sonoki K, Nakamura H, Ansai T
    • Journal Title

      Clin Oral Investig

    • Related Report
      2011 Final Research Report
  • [Journal Article] Physical fitness and 6.5-year mortality in an 85-year old community-dwelling population2012

    • Author(s)
      Takata, Y., Ansai, T., Soh, I., Awano, S., Yoshitake, Y., Kimura, Y, Nakamichi, T., Goto, K, Fujisawa, R., Sonoki, K., Yoshida, A., Toyoshima, K., Nishihara, T.
    • Journal Title

      Arch Gerontol Geriatr

      Volume: 54 Pages: 28-33

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Streptococcus anginosus L-cysteine desulfhydrase gene expression is associated with abscess formation in BALB/c mice2011

    • Author(s)
      Takahashi, Y., Yoshida, A., Nagata, E., Hoshino, T., Oho, T., Awano, S., Takehara, T. and Ansai, T
    • Journal Title

      Molecular Oral Microbiol

      Volume: 26 Pages: 221-227

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] Correlations between health status and OralChroma.-determined volatile sulfide levels in mouth air of the elderly2011

    • Author(s)
      Awano S, Takata Y, Soh I, Yoshida A, Hamasaki T, Sonoki K, Ohsumi T, Nishihara T, Ansai T
    • Journal Title

      J Breath Res

      Volume: 5(4) Pages: 46007-46007

    • Related Report
      2011 Final Research Report
  • [Journal Article] Enumeration of viable Enterococcus faecalis, a predominant apical periodontitis pathogen, using propidium monoazide and quantitative real-time polymerase chain reaction2011

    • Author(s)
      Takahashi Y, Yoshida A, Nagayoshi M, Kitamura C Nishihara T, Awano S, Ansai T
    • Journal Title

      Microbiol Immunol

      Volume: 55(12) Issue: 12 Pages: 889-92

    • DOI

      10.1111/j.1348-0421.2011.00390.x

    • NAID

      10031121546

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Correlations between health status and OralChroma^<TM>-deterinined volatile sulfide levels in mouth air of the elderly2011

    • Author(s)
      Awano S, Takata Y, Soh I, Yoshida A, Hamasaki T, Sonoki K, Ohsumi T, Nishihara T, Ansai T
    • Journal Title

      J Breath Res

      Volume: 5(4)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] イラク復興支援活動従事者のSTAI不安尺度と唾液アミラーゼ活性の関係2011

    • Author(s)
      飯塚尚敬、粟野秀慈、安細敏弘
    • Journal Title

      防衛衛生

      Volume: 58 Pages: 1-5

    • NAID

      40018771853

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 若年層の女性を対象とした口臭に関する意識調査口臭への一般認識と対人行動についてのパイロット研究2011

    • Author(s)
      峰岡哲郎、粟野秀慈、吉田明弘、邵仁浩、濱嵜朋子、安細敏弘
    • Journal Title

      口腔衛生会誌

      Volume: 61 Pages: 282-287

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 歯学科3年次生のPBLテュートリアルに対する学生の評価2011

    • Author(s)
      井上博雅、粟野秀慈、東泉、後藤健一、辻澤利行、大住伴子、高田豊、安細敏弘、西原達次
    • Journal Title

      日本歯科医学教育学会誌

      Volume: 27 Pages: 19-26

    • NAID

      10028179112

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rapid LED-based fluorescence microscopy distinguishes between live and dead bacteria in oral clinical samples2010

    • Author(s)
      Masakiyo, Y., Yoshida, A., Takahashi, Y., Shintani, Y., Awano, S., Ansai, T., Sawayama, S., Shimakita, T. and Takehara, T
    • Journal Title

      Biomed Res

      Volume: 31 Pages: 21-26

    • NAID

      130004903779

    • Related Report
      2011 Final Research Report
  • [Journal Article] Quality of life and physical fitness inan 85-year-old population.2010

    • Author(s)
      Takata, Y., Ansai, T., Soh, I., Awano, S., Yoshitake, Y., Kimura, Y., Sonoki, K., Kagiyama, S., Yoshida, A., Nakamichi, I., Hamasaki, T., Torisu, T., Toyoshima, K., Takehara, T.
    • Journal Title

      Arch Gerontol.Geriatr.

      Volume: 50 Pages: 272-276

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serum albumin levels as an independent predictor of 4-year mortality in a community-dwelling 80-year-old population.2010

    • Author(s)
      Takata, Y., Ansai, T., Soh, I., Awano, S., Sonoki, K., Akifusa, S., Kagiyama, S., Hamasaki, T., Torisu, A., Yoshida, A., Nakamichi, I., Takehara, T.
    • Journal Title

      Aging Clinical and Experimental Research

      Volume: 22 Pages: 31-35

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rapid LED-based fluorescence microscopy distinguishes between live and dead bacteria in oral clinical samples.2010

    • Author(s)
      Masakiyo, Y., Yoshida, A., Takahashi, Y., Shintani, Y., Awano, S., Ansai, T., Sawayama, S., Shimakita, T., Takehara, T
    • Journal Title

      Biomed Res.

      Volume: 31 Pages: 21-26

    • NAID

      130004903779

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between endothelin-1 and interleukin-1 beta in inflamed periodontal tissues2009

    • Author(s)
      Rikimaru, T., Awano, S., Mineoka, T., Yoshida, A., Ansai, T. and Takehara, T
    • Journal Title

      Biomed Res

      Volume: 30 Pages: 349-355

    • NAID

      130004903774

    • Related Report
      2011 Final Research Report
  • [Journal Article] Relationship between endothelin-1 and interleukin-1 beta in inflamed periodontal tissues.2009

    • Author(s)
      Rikimaru, T., Awano, S., Mineoka, T., Yoshida, A., Ansai, T., Takehara, T.
    • Journal Title

      Biomed Res. 30

      Pages: 349-355

    • NAID

      130004903774

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Salivary levels of hyaluronic acid in female patients with dry mouth compared with age-matched controls : a pilot study.2009

    • Author(s)
      Higuchi, Y., Ansai, T., Awano, S., Soh, I., Yoshida, A., Hamasaki, T., Kakinoki, Y., Takehara, T.
    • Journal Title

      Biomed Res. 30

      Pages: 63-68

    • NAID

      130004903750

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Determination of cortisol and dehydroepiandrosterone levels in saliva for screening of periodontitis in older Japanese adults.2009

    • Author(s)
      Ansai, T., Soh, I., Ishisaka, A., Yoshida, A., Awano, S., Hamasaki, T., Sonoki, K., Takata, Y., Takehara, T.
    • Journal Title

      Int J Dent 30

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Determination of cortisol and dehydroepiandrosterone levels in saliva for screening of periodontitis in older Japanese adults

    • Author(s)
      Ansai, T., Soh, I., Ishisaka, A., Yoshida, A., Awano, S., Hamasaki, T., Sonoki, K., Takata, Y. and Takehara, T
    • Journal Title

      Int J Dent

      Volume: 280737 Pages: 8-8

    • Related Report
      2011 Final Research Report
  • [Presentation] 某女子大学生におけるボディーイメージと口臭の意識の関連について2011

    • Author(s)
      Yasunaga, A., Yoshida, A., Masakiyo, Y., Morikawa, K., Maki, K., Soh, I., Awano, S., Ansai, T
    • Organizer
      第33回九州口腔衛生学会総会
    • Place of Presentation
      熊本
    • Year and Date
      2011-10-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] 培養口腔ケラチノサイトにおけるneutral endopeptidaseとsubstance Pとの関係について2011

    • Author(s)
      中田元希, 粟野秀慈, 木下直昌, 峰岡哲郎、吉田明弘、邵仁浩、安細敏弘
    • Organizer
      第71回九州歯科学会総会
    • Place of Presentation
      北九州
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 頬粘膜上皮で発現するメタロプロテアーゼ遺伝子に関するパイロット研究2011

    • Author(s)
      木下直昌、粟野秀慈、中田元希、吉田明弘、邵仁浩、峰岡哲郎、安細敏弘
    • Organizer
      第71回九州歯科学会総会
    • Place of Presentation
      北九州
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 粘膜上皮におけるメタロプロテアーゼの遺伝子発現レベルと歯周健康状態との関係2011

    • Author(s)
      木下直昌、粟野秀慈、中田元希、吉田明弘、邵仁浩、峰岡哲郎、安細敏弘
    • Organizer
      第60回日本口腔衛生学会総会
    • Place of Presentation
      松戸
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 培養口腔ケラチノサイトにおけるneutral endopeptidaseの作用について2011

    • Author(s)
      中田元希、粟野秀慈、木下直昌、峰岡哲郎、吉田明弘、邵仁浩、安細敏弘
    • Organizer
      第60回日本口腔衛生学会総会
    • Place of Presentation
      松戸
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 福岡県在住80歳高齢者を対象にした追跡コホート研究2011

    • Author(s)
      安細敏弘、高田豊、邵仁浩、粟野秀慈、吉田明弘、峰岡哲郎、園木一男、中道郁夫、後藤健一、藤澤律子
    • Organizer
      第71回九州歯科学会総会
    • Place of Presentation
      北九州
    • Related Report
      2011 Annual Research Report
  • [Presentation] 血液透析患者の14年間の口腔健康状態の変化2011

    • Author(s)
      寺谷豪、粟野秀慈、木下直昌、濱嵜朋子、邵仁浩、仲山智恵、吉田明弘、安細敏弘
    • Organizer
      第60回日本口腔衛生学会総会
    • Place of Presentation
      松戸
    • Related Report
      2011 Annual Research Report
  • [Presentation] 入所高齢者における簡易栄養状態評価(MNA)と口腔内因子の関連2011

    • Author(s)
      濱嵜朋子、十亀輝、吉田明弘、邵仁浩、峰岡哲郎、粟野秀慈、安細敏弘
    • Organizer
      第60回日本口腔衛生学会総会
    • Place of Presentation
      松戸
    • Related Report
      2011 Annual Research Report
  • [Presentation] Enumeration of viable cariogenic pathogens assessed by PMA-based real-time PCR2011

    • Author(s)
      Yasunaga, A., Yoshida, A., Masakiyo, Y., Morikawa, K., Maki, K., Soh, I., Awano, S., Ansai, T
    • Organizer
      59th Japanese Association for Dental Research
    • Place of Presentation
      Hiroshima
    • Related Report
      2011 Annual Research Report
  • [Presentation] Neutral Endopeptidase and Endothelin-converting Enzyme in Human Buccal Mucosal Epithelium2010

    • Author(s)
      Kinoshita, N., Awano, S., Yoshida, A., Soh, I., Mineoka, T., and Ansai, T
    • Organizer
      58th Japanese Association for Dental Research
    • Place of Presentation
      Kitakyushu
    • Related Report
      2011 Final Research Report
  • [Presentation] Neutral Endopeptidase and Endothelin-converting Enzyme in Human Buccal Mucosal Epithelium.2010

    • Author(s)
      Kinoshita, N., Awano, S., Yoshida, A., Soh, I., Mineoka, T., Ansai, T.
    • Organizer
      58^<th> Japanese Association for Dental Research
    • Place of Presentation
      Kitakyushua
    • Related Report
      2010 Annual Research Report
  • [Presentation] : Diastolic blood pressure is associated with hydrogen sulphide level in mouth air.2009

    • Author(s)
      Awano, S., Ansai, T., Takata, Y., Soh, I., Yoshida, A., Hamasaki, T., Sonoki, K., Takehara, T.
    • Organizer
      The 8^<th> International Society for Breath Odor Research,
    • Place of Presentation
      Dortmund
    • Year and Date
      2009-04-26
    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www2.kyu-dent.ac.jp/dept/oral-health/

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www2.kyu-dent.ac.jp/dept/oral-health/college/gyoseki/index.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.kenkoyobou.net/college/gyoseki/gyoseki_2010.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.kenkoyobou.net/college/gyoseki/gyoseki_2009.html

    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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