| Project/Area Number |
21592660
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Social dentistry
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| Research Institution | Meikai University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKESHITA Akira 明海大学, 歯学部, 准教授 (70236454)
HIBINO Yasusi 明海大学, 歯学部, 准教授 (20238322)
MURAKAMI Yukio 明海大学, 歯学部, 准教授 (00286014)
MATSUMOTO Masaru 明海大学, 歯学部, 准教授 (00209652)
SIMIZU Yosiaki 明海大学, 歯学部, 准教授 (90206219)
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| Co-Investigator(Renkei-kenkyūsha) |
HAMADA Nobushiro 神奈川歯科大学, 歯学部, 教授 (20247315)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 予防歯科学 / 病原細菌 / 線毛 / 歯周疾患 / 歯学 / 細菌 / 歯周病原性細菌 / P.gingivalis / 付着 / 歯科バイオマテリアル / P. gingivalis |
|---|
| Research Abstract |
We have been purified the fimbriae of Porphyromonas gingivalis(P. gingivalis) by using GE ATKA plus purchased from General Electric Company. However, we can not obtain the significant amount of the fimbriae for research, and then, we continue to establish methods of purification of the fimbriae ; because it is clearly essential to establish the procedure of the purified fimbriae in the study of pathogenic mechanisms of the bacteria. It was demonstrated that the purified fimbriae bind to the cell and induced the inflammation cytokine, on the other hand, we found the new biological activity of the fimbriae that inhibit the apoptosis of the monocyte like cells, in this study.
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