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The establishment of a guideline of antibiotics and Kampo medicine for periodontal disease therapy

Research Project

Project/Area Number 21592671
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Social dentistry
Research InstitutionOsaka Dental University (2010-2011)
Matsumoto Dental University (2009)

Principal Investigator

OH Hourei  大阪歯科大学, 歯学部, 教授 (20213613)

Co-Investigator(Kenkyū-buntansha) IMAMURA Yasuhiro  松本歯科大学, 歯学部, 講師 (00339136)
藤波 義明  松本歯科大学, 歯学部, 助手 (80392801)
吉成 伸夫  松本歯科大学, 歯学部, 教授 (20231699)
Co-Investigator(Renkei-kenkyūsha) FUJINAMI Yoshiaki  松本歯科大学, 歯学部, 助手 (80392801)
YOSHINARI Nobuo  松本歯科大学, 歯学部, 教授 (20231699)
ARA Toshiaki  松本歯科大学, 歯学部, 助教 (90387423)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords抗菌薬 / 漢方薬 / 歯周疾患治療 / ガイドライン / 歯周疾患治療薬 / 慢性歯周炎
Research Abstract

In this study, antibiotics are effective against treatment resistant periodontitis in incurable periodontitis after initial preparation. Kampo medicine inhibited inflammation in vitoro periodontal disease model. These results contributes the establishment of a guideline of antibiotics and Kampo medicine for periodontal disease therapy.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (42 results)

All 2012 2011 2010

All Journal Article (17 results) (of which Peer Reviewed: 17 results) Presentation (20 results) Book (5 results)

  • [Journal Article] Preliminary Evidence of an association between the interleukin-13 gene polymorphisma and periodontal disease in the Japanese population2011

    • Author(s)
      Yusuke Komazaki, Yasuhiro Imamura, Kazuhiro Yamada, Pao-Li Wang
    • Journal Title

      Journal of Hard Tissue Biology

      Volume: 20 Pages: 1-6

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] バイオフィルム感染症としての歯周病抗菌薬物療法2011

    • Author(s)
      王宝禮
    • Journal Title

      Bacterial Adherence & Biofilm

      Volume: 25 Pages: 15-24

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 漢方煎薬の電子レンジ抽出法によるエキス含量とグリチルリチン酸濃度比較研究2011

    • Author(s)
      瀧沢務、藤波義明、荒敏昭、今村泰弘、宮澤裕夫、王宝禮
    • Journal Title

      日本歯科東洋医学会雑誌

      Volume: 30 Pages: 25-17

    • NAID

      10029548932

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 歯科口腔外科における漢方薬の使用状況-一般歯科診療所における使用実態調査2011

    • Author(s)
      砂川正隆, 王宝禮, 影向範昭, 亀山史, 椋梨兼彰, 森純信, 槙石武美, 高橋真一
    • Journal Title

      日本歯科東洋医学会雑誌

      Volume: 30 Pages: 8-17

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 口腔疾患に対する漢方医学2011

    • Author(s)
      王宝禮
    • Journal Title

      歯科薬物療法

      Volume: 30 Pages: 65-76

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 口腔不定愁訴としての舌痛症への漢方治療2011

    • Author(s)
      王宝禮, 王龍三
    • Journal Title

      日本東洋心身医学研究会誌

      Volume: 26 Pages: 75-79

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 口腔疾患に有効な漢方薬を科学する2011

    • Author(s)
      王宝禮
    • Journal Title

      日本歯科医師会雑誌

      Volume: 64 Pages: 1129-1139

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of Novel Therapy for Oral Disease using Kampo Medicines2010

    • Author(s)
      Ara T, Hattori T, Imamura Y, Wang PL
    • Journal Title

      Journal of Oral Biosciences

      Volume: 52(2) Pages: 100-106

    • NAID

      10027105526

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Roles of oral bacteria in cardiovascular disease-From molecular mechanisms to clinical cases : Treatment of periodontal disease regarded as biofilm infection : systemic administration of azithromycin2010

    • Author(s)
      Wang PL
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 113(2) Pages: 126-133

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Preventive effects of a kampo medicine, hangeshashinto on inflammatory responses in lipopolysaccharide-treated human gingival fibroblasts2010

    • Author(s)
      Nakazono Y, Ara T, Fujinami Y Hattori T, Wang PL
    • Journal Title

      Jourrnal of Hard Tissue Biology

      Volume: 19(1) Pages: 43-49

    • NAID

      10030688335

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 口腔不定愁訴に対する漢方治療2010

    • Author(s)
      王宝禮
    • Journal Title

      日本歯科東洋医学会誌

      Volume: 29(1) Pages: 1-5

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Treatment of Periodontal Disease regarded as Biofilm infection : Systemic Administration of Azithromycin2010

    • Author(s)
      Pao-Li Wang
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 113 Pages: 126-133

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 口腔不定愁訴に対する漢方治療2010

    • Author(s)
      王宝禮
    • Journal Title

      日本歯科東洋医学会雑誌

      Volume: 29 Pages: 1-5

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 歯科口腔外科における漢方薬の使用状況2010

    • Author(s)
      砂川正隆、王宝禮、影向範昭、亀山敦史、椋梨兼彰、森純信、槇石武美、高橋真一
    • Journal Title

      日本歯科東洋医学雑誌

      Volume: 29 Pages: 15-23

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 高速液体クロマトグラフィーによる漢方エキス製剤と煎薬の成分比較研究2010

    • Author(s)
      瀧澤努、藤波義明、荒敏明、今村泰弘、宮澤裕夫、王宝禮
    • Journal Title

      日本歯科東洋医学雑誌

      Volume: 29 Pages: 24-27

    • NAID

      10026612020

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preventive effects of a Kampo Medicine, Hangesyashinto on inflammation response in lipopolysaccharide-treated human gingival fibroblasts2010

    • Author(s)
      Yodai Nakazono, Toshiaki Ara, Yoshiaki Fujinaki, Toshifumi Hattori, Pao-Li Wang
    • Journal Title

      Journal of Hard Tissue Biology

      Volume: 19 Pages: 43-50

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 口腔不定愁訴に対する補剤を用いた漢方治療2010

    • Author(s)
      王宝禮、王龍三
    • Journal Title

      日本東洋心身医学研究

      Volume: 25 Pages: 84-88

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 精神的口臭症に対する漢方治療2012

    • Author(s)
      王宝禮
    • Organizer
      第47回日本東洋心身医学研究会
    • Place of Presentation
      東京都港区
    • Year and Date
      2012-03-10
    • Related Report
      2011 Final Research Report
  • [Presentation] 精神的口臭症に対する漢方治療2012

    • Author(s)
      王宝禮
    • Organizer
      第48回日本東洋心身医学研究会
    • Place of Presentation
      東京都
    • Year and Date
      2012-03-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] 歯科口腔外科領域の漢方治療のEBM2011

    • Author(s)
      王宝禮
    • Organizer
      第29回日本歯科東洋医学会学術大会
    • Place of Presentation
      東京都
    • Year and Date
      2011-11-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] 歯科口腔外科漢方領域のEBM2011

    • Author(s)
      砂川正隆、王宝禮
    • Organizer
      第29回日本歯科東洋医学学術総会
    • Place of Presentation
      東京都荒川区
    • Year and Date
      2011-11-26
    • Related Report
      2011 Final Research Report
  • [Presentation] 口腔疾患に対する症例漢方療法に関する臨床研究2011

    • Author(s)
      王宝禮
    • Organizer
      平成23年度日本東洋医学会関西支部例会
    • Place of Presentation
      大阪府大阪市
    • Year and Date
      2011-10-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] 慢性歯周病治療への補剤を用いた漢方治療2011

    • Author(s)
      王宝禮、瀧沢努
    • Organizer
      第27回日本耳鼻咽喉科漢方研究会学術集会
    • Place of Presentation
      東京都港区
    • Year and Date
      2011-10-22
    • Related Report
      2011 Final Research Report
  • [Presentation] 慢性歯周病治療への補剤を用いた漢方治療2011

    • Author(s)
      王宝禮
    • Organizer
      第27回日本耳鼻咽喉科漢方研究会学術集会
    • Place of Presentation
      東京都
    • Year and Date
      2011-10-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] 慢性歯周炎に対する補剤を用いた漢方薬物療法2011

    • Author(s)
      王宝禮
    • Organizer
      第54回秋季日本歯周病学会学術大会
    • Place of Presentation
      山口県下関市
    • Year and Date
      2011-09-24
    • Related Report
      2011 Final Research Report
  • [Presentation] 慢性歯周炎に対する補剤を用いた漢方薬物療法2011

    • Author(s)
      王宝禮
    • Organizer
      2011年日本歯周病学会秋季学術大会
    • Place of Presentation
      山口県下関市
    • Year and Date
      2011-09-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] 歯周病治療におけるアジスロマイシン投与の考え方-歯周病抗菌療法の診療ガイドラインをふまえて-2011

    • Author(s)
      王宝禮
    • Organizer
      第25回Bacterial Adherence & Biofilm
    • Place of Presentation
      東京都
    • Year and Date
      2011-07-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] 医科歯科連携による西洋薬と漢方薬による舌痛症治療2011

    • Author(s)
      瀧沢努、王宝禮、王龍三
    • Organizer
      第62回日本東洋医学会学術総会
    • Place of Presentation
      北海道札幌市
    • Year and Date
      2011-06-12
    • Related Report
      2011 Final Research Report
  • [Presentation] 医科歯科連携による西洋薬と漢方薬による舌痛症治療2011

    • Author(s)
      王宝禮
    • Organizer
      第62回日本東洋医学会総会
    • Place of Presentation
      北海道札幌市
    • Year and Date
      2011-06-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] 急性歯周膿瘍に対する排膿散及湯の効果2011

    • Author(s)
      王宝禮
    • Organizer
      第47回日本東洋心身医学研究会
    • Place of Presentation
      東京都港区
    • Year and Date
      2011-03-05
    • Related Report
      2011 Final Research Report
  • [Presentation] 急性歯周膿瘍に対する排膿散及湯の効果2011

    • Author(s)
      王宝禮
    • Organizer
      第47回日本東洋心身医学研究会
    • Place of Presentation
      東京都
    • Year and Date
      2011-03-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] Development of the Novel Therapy for Oral Disease using Kampo medicine2010

    • Author(s)
      Wang PL
    • Organizer
      2010年度中国国際口腔医学大会
    • Place of Presentation
      中国廈門市
    • Year and Date
      2010-12-03
    • Related Report
      2011 Final Research Report
  • [Presentation] Development of the Novel Therapy for Oral Disease using Kampo medicine2010

    • Author(s)
      Pao-Li Wang
    • Organizer
      2010年度中国国際口腔医学大会
    • Place of Presentation
      中国
    • Year and Date
      2010-12-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] 漢方煎薬の抽出法別成分濃度比較研究2010

    • Author(s)
      王宝禮、瀧沢努、宮澤裕夫
    • Organizer
      第28回日本歯科東洋医学学術総会
    • Place of Presentation
      福島県郡山市
    • Year and Date
      2010-11-07
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 排膿散及湯による歯周病治療の実際2010

    • Author(s)
      王宝禮、瀧沢努
    • Organizer
      第26回日本耳鼻咽喉科漢方研究会学術集会
    • Place of Presentation
      東京都千代田区
    • Year and Date
      2010-10-02
    • Related Report
      2011 Final Research Report
  • [Presentation] 排膿散及湯による歯周病治療の実際2010

    • Author(s)
      王宝禮、瀧澤努
    • Organizer
      第26回日本耳鼻咽喉科漢方研究会学術集会
    • Place of Presentation
      東京都
    • Year and Date
      2010-10-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] 急性歯周膿瘍に対する排膿散及湯の効果2010

    • Author(s)
      王宝禮
    • Organizer
      第53回秋季日本歯周病学会学術大会
    • Place of Presentation
      香川県高松市
    • Year and Date
      2010-09-19
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Book] 薬'12/'13歯科疾患名から治療薬と処方例がすぐわかる本2012

    • Author(s)
      王宝禮
    • Publisher
      クインテッセンス出版
    • Related Report
      2011 Final Research Report
  • [Book] 歯周病患者における抗菌療法の指針2011

    • Author(s)
      王宝禮
    • Publisher
      医歯薬出版
    • Related Report
      2011 Final Research Report
  • [Book] 歯周病患者における抗菌療法の指針(日本歯周病学会編)2011

    • Author(s)
      王宝禮
    • Total Pages
      98
    • Publisher
      医歯薬出版
    • Related Report
      2011 Annual Research Report
  • [Book] 口腔領域と漢方医学2011

    • Author(s)
      王宝禮
    • Total Pages
      19
    • Publisher
      TSUMURA Medical Today
    • Related Report
      2011 Annual Research Report
  • [Book] 薬10/11歯科 疾患名から治療薬と処方例がすぐわかる本2010

    • Author(s)
      朝波惣一郎、王宝禮
    • Total Pages
      197
    • Publisher
      クインテッセンス出版
    • Related Report
      2010 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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