| Project/Area Number |
21600004
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
疼痛学
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KATANOSAKA Yuki 岡山大学, 大学院・医歯薬学総合研究科, 助教 (60432639)
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| Co-Investigator(Renkei-kenkyūsha) |
MIZUMURA Kazue 中部大学, 生命健康科学部, 教授 (00109349)
TAGUCHI Toru 名古屋大学, 環境医学研究所, 助教 (90464156)
KATANOSAKA Yuki 岡山大学, 大学院・医歯薬学総合研究科, 助教 (60432639)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 温度受容 / 痛覚 / TRPチャネル / 侵害受容器 / 一次知覚ニューロン / 温度感覚 / 熱 / pERK / 痛み / 温度 / 感覚 / 受容体 / 冷痛覚過敏 / TRPV2 |
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| Research Abstract |
The mechanisms of heat-and cold-nociception in the nociceptive sensory neurons were examined in rat and mice. No clear correlation between temperature sensitivities of the primary sensory neurons in dorsal root ganglion(DRG) and expression of molecular candidates for nociceptive cold and heat receptors, such as TRPA1 and V2channels, was observed in cultured DRG neurons and anesthetized animals. The data suggested the involvement of other mechanisms independent of these candidate molecules. In addition, I have improved a cold pain assay(cold plate test) to clearly observe the cold pain-related behavior in normal rats and cold hyperalgesia in inflamed rats.
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