• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Elucidation of the mechanisms of nociceptor excitation by noxious temperature

Research Project

Project/Area Number 21600004
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 疼痛学
Research InstitutionNagoya University

Principal Investigator

KATANOSAKA Kimiaki  名古屋大学, 環境医学研究所, 助教 (50335006)

Co-Investigator(Kenkyū-buntansha) KATANOSAKA Yuki  岡山大学, 大学院・医歯薬学総合研究科, 助教 (60432639)
Co-Investigator(Renkei-kenkyūsha) MIZUMURA Kazue  中部大学, 生命健康科学部, 教授 (00109349)
TAGUCHI Toru  名古屋大学, 環境医学研究所, 助教 (90464156)
KATANOSAKA Yuki  岡山大学, 大学院・医歯薬学総合研究科, 助教 (60432639)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords温度受容 / 痛覚 / TRPチャネル / 侵害受容器 / 一次知覚ニューロン / 温度感覚 / 熱 / pERK / 痛み / 温度 / 感覚 / 受容体 / 冷痛覚過敏 / TRPV2
Research Abstract

The mechanisms of heat-and cold-nociception in the nociceptive sensory neurons were examined in rat and mice. No clear correlation between temperature sensitivities of the primary sensory neurons in dorsal root ganglion(DRG) and expression of molecular candidates for nociceptive cold and heat receptors, such as TRPA1 and V2channels, was observed in cultured DRG neurons and anesthetized animals. The data suggested the involvement of other mechanisms independent of these candidate molecules. In addition, I have improved a cold pain assay(cold plate test) to clearly observe the cold pain-related behavior in normal rats and cold hyperalgesia in inflamed rats.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (13 results)

All 2011 2010 2009

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (11 results)

  • [Journal Article] TRPV3 in keratinocytes transmits temperature information to sensory neurons via ATP.2009

    • Author(s)
      Mandani S, Sokabe T, Shibasaki K, Katanosaka K, Mizuno A, Moqrich A, Patapoutian A, Fukumi-Tominaga T, Mizumura K, Tominaga M
    • Journal Title

      Pflugers Archiv-European Journal of Physiology

      Volume: 458(6) Pages: 1093-1102

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Excitation and sensitization of nociceptors by bradykinin : What do we know?2009

    • Author(s)
      Mizumura K, Sugiura T, Katanosaka K, Banik RK, Kozaki Y
    • Journal Title

      Experimental Brain Research

      Volume: 196(1) Pages: 53-65

    • Related Report
      2011 Final Research Report
  • [Presentation] Role of TRPV1 in mechanically induced pain2011

    • Author(s)
      Murase S, Ota H, Katanosaka K, KuboA, Queme F, Matsuda T, Taguchi T, Mizumura K
    • Organizer
      International Symposium on Mechano-biology(The Fifth Shanghai International Conference on Biophysics and Molecular biology)
    • Place of Presentation
      Huashia Hotel(Shanghai, CHINA)
    • Year and Date
      2011-11-05
    • Related Report
      2011 Final Research Report
  • [Presentation] Role of TRPV1 in mechanically induced pain2011

    • Author(s)
      Murase S, Ota H, Katanosaka K, Kubo A, Queme F, Matsuda T, Taguchi T, Mizumura K
    • Organizer
      International Symposium on Mechanobiology (The Fifth Shanghai International Conference on Biophysics and Molecular biology)
    • Place of Presentation
      Huashia Hotel (Shanghai, CHINA)(招待講演)
    • Year and Date
      2011-11-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] The chemical sensitivities and expression of cold-sensitive ionchannels in sensory neurons in the persistently inflamed rat2011

    • Author(s)
      Katanosaka K, Ota T, Hirose T, MoriK, Mizumura K
    • Organizer
      The 8th International Congress on Comparative Physiology and Biochemistry
    • Place of Presentation
      Nagoya Congress Center(Nagoya, JAPAN)
    • Related Report
      2011 Final Research Report
  • [Presentation] The chemical sensitivities and expression of cold-sensitive ion channels in sensory neurons in the persistently inflamed rat2011

    • Author(s)
      Katanosaka K, Ota T, Hirose T, Mori K, Mizumura K
    • Organizer
      The 8th International Congress on Comparative Physiology and Biochemistry
    • Place of Presentation
      Nagoya Congress Center (Nagoya, JAPAN)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 繰り返し寒冷ストレスによる機械痛覚過敏における性差2010

    • Author(s)
      那須輝顕,片野坂公明,水村和枝
    • Organizer
      第49回日本生気象学会大会
    • Place of Presentation
      文化女子大学(東京)
    • Year and Date
      2010-11-05
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] Sex difference of repeated cold stress(RCS)-induced cutaneous and muscular mechanical hyperalgesia in rats2010

    • Author(s)
      Nasu T, Katanosaka K, Mizumura K
    • Organizer
      第87回日本生理学会大会
    • Place of Presentation
      盛岡市民文化ホール(盛岡)
    • Year and Date
      2010-05-20
    • Related Report
      2011 Final Research Report
  • [Presentation] Sex difference of repeated cold stress(RCS)-induced cutaneous and muscular mechanical hyperalgesia in rats.2010

    • Author(s)
      NASU Teruaki, KATANOSAKA, Kimiaki, MIZUMURA Kazue
    • Organizer
      第87回日本生理学会大会
    • Place of Presentation
      盛岡市民文化ホール(盛岡)
    • Year and Date
      2010-05-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] プロスタグランジンはEP3受容体を介して、内在化したブラジキニンB2受容体のリサイクリングに作用する可能性がある2010

    • Author(s)
      Kozaki Y, Suzuki Y, Katanosaka K, Mori M, Mizumura K
    • Organizer
      第33回日本神経科学会(Neuro 2010)
    • Place of Presentation
      神戸コンベンションセンター(神戸)
    • Related Report
      2011 Final Research Report
  • [Presentation] プロスタグランジンEP3受容体の活性化による内在化ブラジキニンB2受容体の細胞膜へのリサイクリングの促進2010

    • Author(s)
      小崎康子,鈴木義明,片野坂公明,森雅美,水村和枝
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山コンベンションセンター(岡山)
    • Related Report
      2011 Final Research Report
  • [Presentation] Behavioral hyper-sensitivity to noxious cold and functional changes of DRG neurons of the rats suffering from persistent joint inflammation2009

    • Author(s)
      Katanosaka K, Ota T, Hirose T, MoriK, Mizumura K
    • Organizer
      The 36th Congress of the International Union of Physiological Sciences(IUPS2009)
    • Place of Presentation
      Kyoto International Conference Center(KYOTO, JAPAN)
    • Year and Date
      2009-07-29
    • Related Report
      2011 Final Research Report
  • [Presentation] Behavioral hypersensitivity to noxious cold and functional changes of DRG neurons of the rats suffering from persistent joint inflammation2009

    • Author(s)
      Katanosaka K, Ota T, Hirose T, Mori K, Mizumura K
    • Organizer
      The 36th Congress of the International Union of Physiological Sciences(IUPS2009)
    • Place of Presentation
      KYOTO
    • Related Report
      2009 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi