Clarification of dorsal root evoked synaptic responses in lamina I neurons
| Project/Area Number |
21600005
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
疼痛学
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| Research Institution | Kumamoto Health Science University |
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Principal Investigator |
YOSHIMURA Megumu 熊本保健科学大学, 大学院・保健科学研究科, 教授 (10140641)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | slow EPSP / サブスタンスP / 後角第I層 / 投射ニューロン / 脊髄第I層 / 緩徐シナプス応答 / C線維 / ペプチド / 痛覚伝達 / 脊髄後角 / 痛覚過敏 / 脊髄スライス / slow EPSC / 痛覚 / 脊髄スライス標本 / 無髄のC線維 |
|---|
| Research Abstract |
Intracellular recordings were made from lamina I neurons which were identified by antidromic action potentials evoked by focal stimulation near the central canal. Stimulation of the dorsal root elicited a fast EPSP in the majority of neurons and repetitive stimulation evoked a slow EPSP in 20% of lamina I neurons. The latter neurons were depolarized by application of substance P and antagonized by a NK1 receptor antagonist, suggesting that the lamina I neurons receive substance P containing C afferent fibers which could modulate the nociceptive transmission in the lamina I.
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Report
(4 results)
Research Products
(45 results)
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[Presentation]2011
Author(s)
吉村惠
Organizer
九州痲酔学会特別講演
Place of Presentation
福岡,日本
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