Modulation of nociceptive genes by in vivo RNA interference in rats and application to pain treatment
| Project/Area Number |
21600006
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
疼痛学
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| Research Institution | Nagasaki University |
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Principal Investigator |
TODA Kazuo 長崎大学, 医歯薬学総合研究科, 教授 (80134708)
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| Co-Investigator(Kenkyū-buntansha) |
KIMOTO Mari 日本女子大学, 家政学部, 准教授 (60101565)
池田 通 長崎大学, 医歯薬学総合研究科, 教授 (00211029)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 眼窩下神経結紮モデル / 三叉神経脊髄路核 / トランスフェクション / RNA干渉 / フォンフライ毛 / 外界電位 / 逃避反射 / ラット / 三叉神経 / 侵害受容遺伝子 / 閾値 |
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| Research Abstract |
Neuropathic pain can be very difficult to treat. It may be associated with abnormal sensations called dysesthesia, and pain is produced by normally non-noxious stimuli(allodynia). Recently, it is reported that nociceptive-genes are strongly concerned with producing neuropathic pain and inhibition of nocicptive-gene expression is one of the tools to treat neuropathic pain. This study revealed that inhibition of nocicptive-genes by in vivo RNA interference elevated threshold value to mechanical noxious stimuli.
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Report
(4 results)
Research Products
(23 results)
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[Presentation] Nociceptive behaviors in rats at low gravity conditions, EFIC-conferences2009
Author(s)
Ishida, T, Zeredo JL, Yabushita T, Seki S, Fusejima Y, Fukushima G, Toda K, Kumei Y
Organizer
Pain in Europe VI
Place of Presentation
Lisbon, Portugal
Year and Date
2009-09-12
Related Report
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