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Modulation of nociceptive genes by in vivo RNA interference in rats and application to pain treatment

Research Project

Project/Area Number 21600006
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 疼痛学
Research InstitutionNagasaki University

Principal Investigator

TODA Kazuo  長崎大学, 医歯薬学総合研究科, 教授 (80134708)

Co-Investigator(Kenkyū-buntansha) KIMOTO Mari  日本女子大学, 家政学部, 准教授 (60101565)
池田 通  長崎大学, 医歯薬学総合研究科, 教授 (00211029)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords眼窩下神経結紮モデル / 三叉神経脊髄路核 / トランスフェクション / RNA干渉 / フォンフライ毛 / 外界電位 / 逃避反射 / ラット / 三叉神経 / 侵害受容遺伝子 / 閾値
Research Abstract

Neuropathic pain can be very difficult to treat. It may be associated with abnormal sensations called dysesthesia, and pain is produced by normally non-noxious stimuli(allodynia). Recently, it is reported that nociceptive-genes are strongly concerned with producing neuropathic pain and inhibition of nocicptive-gene expression is one of the tools to treat neuropathic pain. This study revealed that inhibition of nocicptive-genes by in vivo RNA interference elevated threshold value to mechanical noxious stimuli.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (23 results)

All 2012 2011 2010 2009

All Journal Article (10 results) (of which Peer Reviewed: 7 results) Presentation (9 results) Book (4 results)

  • [Journal Article] Hypergravity conditioning on ileal movements in rats2012

    • Author(s)
      Kimoto M, Zeredo JL, Toda K
    • Journal Title

      Aviation, Space and Environmental Medicine

      Volume: (in press)

    • NAID

      120006986781

    • Related Report
      2011 Final Research Report
  • [Journal Article] Efferent Fibers Innervate Gustatory and Mechanosensitive Afferent Fibers in Frog Fungiform Papillae2012

    • Author(s)
      Sato T, Nishishita K, Okada Y, Toda K
    • Journal Title

      Chem Senses

      Volume: (印刷中) Issue: 4 Pages: 315-324

    • DOI

      10.1093/chemse/bjr096

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Irritant-drinking Behaviour can be Modifi ed by gravity-stress loaded in developing but not in adult rats2011

    • Author(s)
      Kimoto M, Zeredo JL, Toda K
    • Journal Title

      Stress and Health

      Volume: 27 Pages: 34-41

    • Related Report
      2011 Final Research Report
  • [Journal Article] Irritant-drinking Behaviour can be Modified by Gravity-stress Loaded in Developing but not in Adult Rats2011

    • Author(s)
      Kimoto M, Zeredo JL, Toda K
    • Journal Title

      Stress and Health

      Volume: 27 Issue: 1 Pages: 34-41

    • DOI

      10.1002/smi.1317

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Irritant-drinking behaviour can be modified by gravity-stress in rats2011

    • Author(s)
      Kimoto M, Zerdo JL, Toda K
    • Journal Title

      Stress and Health

      Volume: 27 Pages: 34-41

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Response properties of nucleus reticularis lateralis neurons after electroacupuncture stimulation in rats2010

    • Author(s)
      Moritaka K, Zeredo JL, Kimoto M, Nasution FH, Hirano T, Toda K
    • Journal Title

      Am J Chin Med

      Volume: 38(5) Pages: 869-80

    • NAID

      120006984970

    • Related Report
      2011 Final Research Report
  • [Journal Article] Response properties of nucleus reticularis lateralis after electroacupuncture stimulation in rats2010

    • Author(s)
      Moritaka, K, Zeredo JL, Kimoto M, NasutionFH, Hirano T, Toda K
    • Journal Title

      Amer J Chin Med

      Volume: 38 Pages: 869-880

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Trigeminal irritant-induced behavior can be modified by gravity stress in younger rats2009

    • Author(s)
      Kimoto M, Zerdo JL, Kumei Y, Toda, K :
    • Journal Title

      European J Pain 13

      Pages: 99-99

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interaction between gustatory depolarizing receptor potential and efferent-induced slow depolarizing synaptic potential in frog taste cell2009

    • Author(s)
      Sato T, Nishishita K, Okada Y, Toda K
    • Journal Title

      Cell Mol Neurobiol 29

      Pages: 243-245

    • NAID

      120006983972

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Measuring biting behavior induced by acute stress in the rat2009

    • Author(s)
      Zeredo JL, Kumei Y, Shibazaki T, Yoshida N, Toda K
    • Journal Title

      Behav Res Method 41

      Pages: 761-764

    • NAID

      120006984020

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Antinociceptive effects induced by gravity stress in rats : Sex differences2011

    • Author(s)
      Toda K, Zeredo JL, Moritaka K, Yamashita H, Kaida K, Kimoto M
    • Organizer
      43rd Meeting of the European Brain and Behavior Society(EBBS)
    • Place of Presentation
      Seville, Spain
    • Related Report
      2011 Final Research Report
  • [Presentation] Comparison of stress-induced modulation of smooth muscle activities between small and large intestine in adult rats2011

    • Author(s)
      Kimoto M, Ikezaki M, Kato M, Kohata A, Takashima K, Takeuchi M, Nemoto S, Zeredo JL, Toda K
    • Organizer
      43rd Meeting of the European Brain and Behavior Society(EBBS)
    • Place of Presentation
      Seville, Spain
    • Related Report
      2011 Final Research Report
  • [Presentation] Signaling pathway in extracellular calcium sensing of frog parathyroid cells2011

    • Author(s)
      Okada Y, Miyazaki T, Hotokezaka H, Fujiyama R, Toda K
    • Organizer
      ICCPB2011
    • Place of Presentation
      Nagoya, Japan
    • Related Report
      2011 Final Research Report
  • [Presentation] Antinociceptive effects induced by gravity stress in rats : Sex differences2011

    • Author(s)
      K.Toda, J.L Zeredo, K.Moritaka, H.Yamashita, K.Kaida, M.Kimoto
    • Organizer
      43rd Meeting of the European Brain and Behavior Society (EBBS)
    • Place of Presentation
      Seville, Spain
    • Related Report
      2011 Annual Research Report
  • [Presentation] Stress-induced modulation of ileal peristaltic movement in rats2010

    • Author(s)
      Kimoto M, Kumei Y, Zeredo JL, Toda K
    • Organizer
      7th World Congress on Stress, Leiden
    • Place of Presentation
      The Netherlands
    • Related Report
      2011 Final Research Report
  • [Presentation] Stress-induced modulation of ileal peristaltic movements in rats2010

    • Author(s)
      Kimoto M, Kumei Y., Zeredo JL, Toda K
    • Organizer
      7^<th> Wolrd Congress on Stress
    • Place of Presentation
      Leiden, The Netherland
    • Related Report
      2010 Annual Research Report
  • [Presentation] Nociceptive behaviors in rats at low gravity conditions, EFIC-conferences2009

    • Author(s)
      Ishida, T, Zeredo JL, Yabushita T, Seki S, Fusejima Y, Fukushima G, Toda K, Kumei Y
    • Organizer
      Pain in Europe VI
    • Place of Presentation
      Lisbon, Portugal
    • Year and Date
      2009-09-12
    • Related Report
      2011 Final Research Report
  • [Presentation] Trigeminal irritant-induced behavior can be modified by gravity stress in younger rats, EFIC-conferences2009

    • Author(s)
      Kimoto M, Zeredo JL, Kumei Y, Toda K
    • Organizer
      Pain in Europe VI
    • Place of Presentation
      Lisbon, Portugal
    • Related Report
      2011 Final Research Report
  • [Presentation] Trigeminal irritant-induced behavior can be modified by gravity stress in younger rats2009

    • Author(s)
      Kimoto, J.L.Zeredo, Y.Kumei, K.Toda
    • Organizer
      EFIC-conferences, "Pain in Europe VI"
    • Place of Presentation
      Lisbon, Portugal,
    • Related Report
      2009 Annual Research Report
  • [Book] 基礎解剖生理学第3版2011

    • Author(s)
      戸田一雄,木本万里
    • Publisher
      おうふう出版
    • Related Report
      2011 Final Research Report
  • [Book] はじめての痛み学2011

    • Author(s)
      植田弘師,戸田一雄
    • Publisher
      おうふう出版
    • Related Report
      2011 Final Research Report
  • [Book] 基礎解剖生理学 第3版2011

    • Author(s)
      戸田一雄、木本万里
    • Total Pages
      456
    • Publisher
      おうふう
    • Related Report
      2010 Annual Research Report
  • [Book] 基礎解剖生理学2009

    • Author(s)
      戸田一雄、木本万里
    • Total Pages
      434
    • Publisher
      おうふう
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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