| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Research Abstract |
This study examined the mechanism underlying suppression of analgesic tolerance to morphine under chronic pain condition. Chronic pain was induced by intraplantar injection of 1% formalin, which significantly suppressed the development of analgesic tolerance to morphine. The formalin-induced suppression of analgesic tolerance to morphine was significantly reversed by L-arginine, a precursor of nitric oxide, but not by D-arginine. These results suggest that suppression of analgesic tolerance to morphine under formalin-induced pain may be mediated through the inhibition of nitric oxide production.
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