Elucidation of the mechanism underlying the suppression of the development of analgesic tolerance to morphine under chronic pain
Project/Area Number |
21600012
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
疼痛学
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Research Institution | Tohoku Pharmaceutical University |
Principal Investigator |
TAN-NO Koichi 東北薬科大学, 薬学部, 教授 (20207260)
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Project Period (FY) |
2009 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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Keywords | モルヒネ / 鎮痛耐性 / 身体的依存 / 慢性疼痛 / 一酸化窒素 / ホルマリン試験 / マウス / 炎症性疼痛 / NMDA受容体 / AMPA受容体 / L型カルシウムチャネル / DNAマイクロアレイ解析 / NOS1AP |
Research Abstract |
This study examined the mechanism underlying suppression of analgesic tolerance to morphine under chronic pain condition. Chronic pain was induced by intraplantar injection of 1% formalin, which significantly suppressed the development of analgesic tolerance to morphine. The formalin-induced suppression of analgesic tolerance to morphine was significantly reversed by L-arginine, a precursor of nitric oxide, but not by D-arginine. These results suggest that suppression of analgesic tolerance to morphine under formalin-induced pain may be mediated through the inhibition of nitric oxide production.
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Report
(5 results)
Research Products
(24 results)
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[Journal Article] Suppressive effects by cysteine protease inhibitors on naloxone-precipitated withdrawal jumping in morphine-dependent mice2010
Author(s)
Tan-No K., Sato T., Shimoda M., Nakagawasai O., Niijima F., KawamuraS., Furuta S., Sato T., Satoh S., Silberring J., Terenius L., Takeshi Tadano
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Journal Title
Neuropeptides
Volume: 44
Issue: 3
Pages: 279-283
DOI
Related Report
Peer Reviewed
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