Effect of GABA on excitatory conduction in nociceptive sensory neurons

• Project/Area Number: 21600014
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: 疼痛学
• Research Institution: Kyorin University
• Principal Investigator: YAGI Junichi 杏林大学, 医学部, 講師 (90265760)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 神経科学 / 痛覚 / 感覚神経 / シナプス前抑制 / パッチクランプ記録 / パッチクランプ

Research Abstract

Signal transmission from sensory neurons to the secondary neurons in the spinal cord is modulated by presynaptic inhibition, in whichg-aminobutyric acid(GABA) reduces release of neurotransmitters in the presynaptic sensory neuronal terminals. A novel method was developed toinvestigate the underlying mechanisms. It was suggested that the presynaptic inhibition would be due to GABA-induced membrane depolarization, leading to a blockade of action potential propagation.

Research Products

• [Journal Article] 麻酔下全動物標本による「骨格筋DRGニューロン」のホールセルパッチクランプ記録 (2009)
  • Author(s): 八木淳一
  • Journal Title: Rain Research 24 Pages: 109-116
  • NAID: 10025639080
  • Peer Reviewed
• [Presentation] Blockade of action potential propagation by GABA(A) receptor activation in rat dorsal root ganglion neurons (2011)
  • Author(s): 八木淳一
  • Organizer: 北米神経科学会
  • Place of Presentation: ワシントンDC
  • Year and Date: 2011-11-14
• [Presentation] Blockade of action potential propagation by GABA(A) receptor activation in rat dorsal root ganglion neurons (2011)
  • Author(s): J. Yagi, Y Kobayashi, EW McCleskey and N Hirai
  • Organizer: Soc. for Neuroscience
  • Place of Presentation: Washington DC
• [Presentation] ASIC3 and muscle ischemic pain (2010)
  • Author(s): 八木淳一
  • Organizer: 第87回日本生理学会、日・韓・中合同シンポジウム-pHセンシングと痛み-
  • Place of Presentation: 盛岡
  • Year and Date: 2010-05-20
• [Presentation] Membrane depolarization is required for muscimol-induced blockade of action potential propagation in rat DRG neurons. (2010)
  • Author(s): 八木淳一
  • Organizer: The Spring Pain Conference 2010
  • Place of Presentation: Grand Cayman
  • Year and Date: 2010-04-20
• [Presentation] 「脊髄後根神経節-神経標本」を用いたシナプス前抑制機構の解析 (2010)
  • Author(s): 八木淳一、小林靖、平井直樹
  • Organizer: 第32回日本疼痛学会
  • Place of Presentation: 京都
• [Presentation] ASIC3 and muscle ischemic pain (2010)
  • Author(s): J. Yagi
  • Organizer: 第87回日本生理学会日・韓・中合同シンポジウム
  • Place of Presentation: 盛岡
• [Presentation] Membrane depolarization is required for muscimol-induced blockade of action potential propagation in rat DRG neurons (2010)
  • Author(s): J. Yagi
  • Organizer: The Spring Pain Conference
  • Place of Presentation: Grand Cayman
• [Presentation] Effect of GABA on Propagated Action Potentials in DRG Neurons using the Ganglion-Nerve Preparation of Rats (2009)
  • Author(s): 八木淳一
  • Organizer: 第36回国際生理学会
  • Place of Presentation: 京都
  • Year and Date: 2009-07-31
• [Presentation] Effect of GABA on propagated action potentials in DRG neurons using the ganglion-nerve preparation of rats (2009)
  • Author(s): J. Yagi, Y. Kobayashi and N. Hirai
  • Organizer: 36th International Congress of Physiological Sciences
  • Place of Presentation: Kyoto