| Project/Area Number |
21600018
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
疼痛学
|
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| Research Institution | Yasuda Women's University |
|---|
Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IDE Soichiro 北海道大学, 大学院・薬学研究院, 助教 (30389118)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
IKEDA Kazutaka (財)東京都医学総合研究所, 参事研究員 (60281656)
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | オピオイド / 痛み / 依存 / 麻薬拮抗性鎮痛薬 / μオピオイド受容体 / 遺伝子欠損マウス / 鎮痛 / MOP-KOマウス / ノルエピネフリントランスポーター / モルヒネ / トラマドール / ブプレノルフィン / ペンタゾシン |
|---|
| Research Abstract |
Although opioid partial agonists are widely used for the management of mild to moderate pain in humans and animals, the pharmacological mechanisms of their effects remain unclear. In the present research, we examined the pharmacological effects of butorphanol, buprenorphine, pentazocine and tramadol. We revealed that these opioid partial agonists exert their analgesic and rewarding effects by mainly acting on theμ-opioid receptor.
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