Pharmacological mechanisms in effects of opioid partial agonists

• Project/Area Number: 21600018
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: 疼痛学
• Research Institution: Yasuda Women's University
• Principal Investigator: SATOH Masamichi 安田女子大学, 薬学部, 教授 (80025709)
• Co-Investigator(Kenkyū-buntansha): IDE Soichiro 北海道大学, 大学院・薬学研究院, 助教 (30389118)
• Co-Investigator(Renkei-kenkyūsha): IKEDA Kazutaka (財)東京都医学総合研究所, 参事研究員 (60281656)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: オピオイド / 痛み / 依存 / 麻薬拮抗性鎮痛薬 / μオピオイド受容体 / 遺伝子欠損マウス / 鎮痛 / MOP-KOマウス / ノルエピネフリントランスポーター / モルヒネ / トラマドール / ブプレノルフィン / ペンタゾシン

Research Abstract

Although opioid partial agonists are widely used for the management of mild to moderate pain in humans and animals, the pharmacological mechanisms of their effects remain unclear. In the present research, we examined the pharmacological effects of butorphanol, buprenorphine, pentazocine and tramadol. We revealed that these opioid partial agonists exert their analgesic and rewarding effects by mainly acting on theμ-opioid receptor.

Research Products

• [Journal Article] (-)-Pentazocine induces visceral chemical antinociception, but not thermal, mechanical, or somatic chemical antinociception, inμ-opioid receptor knockout mice (2011)
  • Author(s): Ide S., Minami M., Uhl G. R., Satoh M., Sora I., Ikeda K
  • Journal Title: Mol. Pain Volume: 7 Pages: 23-23
  • DOI: 10.1186/1744-8069-7-23
  • Peer Reviewed
• [Journal Article] Combination of Cell Culture Assays and Knockout Mouse Analyses for the Study of Opioid Partial Agonism in "Analgesia Methods and Protocols" (2010)
  • Author(s): 井手聡一郎
  • Journal Title: Methods Mol.Biol. Volume: 617 Pages: 363-374
• [Journal Article] (-)-Pentazocine induces visceral chemical antinociception, but not thermal, mechanical, or somatic chemical antinociception, in mu-opioid receptor knockout mice.
  • Author(s): 井手聡一郎
  • Journal Title: Mol.Pain Volume: (In press)
  • Peer Reviewed
• [Presentation] 麻薬拮抗性鎮痛薬の薬理作用機序の検討 (2011)
  • Author(s): 松川遥、井手聡一郎、片山貴博、南雅文
  • Organizer: 医療薬学フォーラム2011
  • Place of Presentation: 旭川
  • Year and Date: 2011-07-09
• [Presentation] 麻薬拮抗性鎮痛薬の薬理作用機序の検討 (2011)
  • Author(s): 松川遥
  • Organizer: 医療薬学フォーラム2011
  • Place of Presentation: 旭川(北海道)
  • Year and Date: 2011-07-09
• [Presentation] 痛み・情動におけるμオピオイド受容体の役割 (2010)
  • Author(s): 井手聡一郎
  • Organizer: 第20回日本臨床精神神経薬理学会、第40回日本神経精神薬理学会合同年会
  • Place of Presentation: 仙台
  • Year and Date: 2010-09-15
• [Book] "Combination of Cell Culture Assays and Knockout Mouse Analyses for the Study of Opioid Partial Agonism" in "Analgesia Methods and Protocols" (2010)
  • Author(s): 井手聡一郎
  • Publisher: Humana Press(印刷中)