• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Functional analysis of G protein-coupled receptor TM7XN1 between niche-hematopoietic stem cells

Research Project

Project/Area Number 21602005
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Stem cell biology and medical science
Research InstitutionBeppu University Junior College (2011)
Kansai Medical University (2009-2010)

Principal Investigator

HASE Makoto  別府大学短期大学部, 准教授 (50425203)

Co-Investigator(Kenkyū-buntansha) SASAKI Yutaka  関西医科大学, 医学部, 講師 (80425066)
ARAKI Satohiko  名古屋大学, 理学(系)研究科(研究院), 講師 (80242808)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords細胞間接着 / GPCRs / 幹細胞 / 細胞内情報伝達系 / G蛋白質共役型受容体 / 細胞接着
Research Abstract

The differentiation and maintenance of stem cells are integral to the development and homeostasis of many tissues, including the tumors. These stem cells often live in specialized functional areas, called niches. However, the molecular mechanisms of stem cells and niches regulatory function remain unclear. Here, using human hematopoietic stem cell(HSC), and cancer stem cell compartment of squamous cancer cell strain A431 cell, we evaluated the level of expression of TM7XN1 and other G protein-coupled receptors(GPCRs) on stem cells, and analyzed how this affects their interaction with niche.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (20 results)

All 2012 2011 2010 2009

All Journal Article (10 results) (of which Peer Reviewed: 9 results) Presentation (9 results) Book (1 results)

  • [Journal Article] ミネラルならびに微量金属元素によるヒト血管内皮細胞への影響2012

    • Author(s)
      長谷真
    • Journal Title

      別府大学短期大学部紀要

      Volume: 第31号 Pages: 1-8

    • NAID

      40019332275

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin-8 enhances the proliferation and angiogenic activity of umbilical cord blood-derived outgrowth endothelial cells in vitro2011

    • Author(s)
      Kimura T, Kohno H, Matsuoka Y, Murakami M, Nakatsuka R, Hase M, Yasuda K, Uemura Y, Sasaki Y, Fukuhara S, Sonoda Y
    • Journal Title

      Cell Biol Int

      Volume: 35(3) Pages: 201-208

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin-8 enhances the proliferation and angiogenic activity of umbilical cord blood-derived outgrowth endothelial cells in vitro.2011

    • Author(s)
      Kimura T
    • Journal Title

      Cell Biology international

      Volume: 35巻 Pages: 201-208

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Natural killer T cell-based adjuvant properties and their application for anti-tumor immune response2010

    • Author(s)
      Narita Y, Hase M, 他11名
    • Journal Title

      Cytometry Research

      Volume: 20 Pages: 19-25

    • NAID

      10026084562

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] ヒト造血幹細胞におけるG蛋白質共役型受容体TM7XN1とその結合蛋白質TG2の機能解析2010

    • Author(s)
      長谷真
    • Journal Title

      平成20年度関西医科大学学内研究助成紀要

      Pages: 51-52

    • Related Report
      2011 Final Research Report
  • [Journal Article] Natural killer T cell-based adjuvant properties and their application for anti-tumor immune response.2010

    • Author(s)
      Narita Y
    • Journal Title

      Cytometry Research

      Volume: 20巻 Pages: 19-25

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Marginal expression of CXCR4 on c-Kit+Sca-1+Lineage-hematopoietic stem/progenitor cells2009

    • Author(s)
      Sasaki Y, Matsuoka Y, Hase M, Toyohara T, Murakami M, Takahashi M, Nakatsuka R, Yasuda K, Uemura Y, Sonoda Y
    • Journal Title

      Int J Hematol

      Volume: 90 Pages: 553-560

    • NAID

      10026109792

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cytokine-dependent modification of IL-12 p70 and IL-23 balance in dendritic cells by ligand activation of Va24 invariant natural killer T cells2009

    • Author(s)
      Uemura Y, Hase M, 他21名
    • Journal Title

      J. Immunol

      Volume: 183 Pages: 201-208

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cytokine-dependent modification of IL-12p70 and IL-23 balance in dendritic cells by ligand activation of Va24 invariant natural killer T cells2009

    • Author(s)
      Uemura Y
    • Journal Title

      J.Immunol. 183

      Pages: 201-208

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Marginal expression of CXCR4 on c-Kit^+Sca-1^+ Lineage^- hematopoietic stem/progenitor cells2009

    • Author(s)
      Sasaki Y
    • Journal Title

      Int J Hematol. 90

      Pages: 553-560

    • NAID

      10026109792

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 健康展~「減塩」について2011

    • Author(s)
      長谷真
    • Organizer
      (ミニ講義)別府大学学内GP「健康展」
    • Place of Presentation
      大分駅
    • Year and Date
      2011-11-19
    • Related Report
      2011 Final Research Report
  • [Presentation] 健康展~「減塩」について(ミニ講義)2011

    • Author(s)
      長谷真
    • Organizer
      別府大学学内GP「健康展」
    • Place of Presentation
      大分駅
    • Year and Date
      2011-11-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] マウス骨髄造血幹/前駆細胞はCXCR4低発現である2009

    • Author(s)
      Sasaki Y, Matsuoka Y, Toyohara T, Hase M, Nakatsuka R, Uemura Y, Sonoda Y
    • Organizer
      第71回日本血液学会総会
    • Place of Presentation
      京都(国立京都国際会館)
    • Year and Date
      2009-10-25
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] Modification of IL-12p70 and IL-23 balance in dendritic cells by Valpha24 invariant NKT cells2009

    • Author(s)
      Uemura Y, Liu T, Narita Y, Suzuki M, Nakatsuka R, Hirosawa N, Matsuoka Y, Murakami M, Hase M, Kohno H, Sasaki Y, Sakamoto Y, Senju S, Sonoda Y
    • Organizer
      第71回日本血液学会総会
    • Place of Presentation
      京都(国立京都国際会館)
    • Year and Date
      2009-10-23
    • Related Report
      2011 Final Research Report
  • [Presentation] Modification of IL-12p70 and IL-23 balance in dendritic cells by Valpha24 invariant NKT cells.2009

    • Author(s)
      植村靖史
    • Organizer
      第71回日本血液学会総会
    • Place of Presentation
      京都(国立京都国際会館)
    • Year and Date
      2009-10-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] Va24インバリアントNKT細胞による樹状細胞のIL12/IL23産生制御2009

    • Author(s)
      鈴木元晴、植村靖史、成田弥生、劉天慾廣澤成美、長谷真、千住覚、坂本安、薗田精昭
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜(パシフィコ横浜)
    • Year and Date
      2009-10-02
    • Related Report
      2011 Final Research Report
  • [Presentation] Va24インバリアントNKT細胞による樹状細胞のIL12/IL23産生制御2009

    • Author(s)
      鈴木元晴
    • Organizer
      第68回日本癌学会
    • Place of Presentation
      横浜(パシフィコ横浜)
    • Year and Date
      2009-10-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] Kinetics of CXCR4 expression on murine steady state KSL cells2009

    • Author(s)
      Sasaki Y, Matsuoka Y, Toyohara T, Hase M, Nakatsuka R, Uemura Y, Sonoda Y
    • Organizer
      第7回幹細胞シンポジウム
    • Place of Presentation
      東京(泉ガーデンギャラリー)
    • Year and Date
      2009-05-15
    • Related Report
      2011 Final Research Report
  • [Presentation] Kinetics of CXCR4 expression on murine steady state KSL cells2009

    • Author(s)
      佐々木豊
    • Organizer
      第7回 幹細胞シンポジウム
    • Place of Presentation
      東京(泉ガーデンギャラリー)
    • Year and Date
      2009-05-15
    • Related Report
      2009 Annual Research Report
  • [Book] Vascular apoptosis-inducing protein 1. Handbook of Proteolytic Enzymes, third edition2011

    • Author(s)
      Araki S
    • Related Report
      2011 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi