Functional analysis of G protein-coupled receptor TM7XN1 between niche-hematopoietic stem cells
| Project/Area Number |
21602005
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Stem cell biology and medical science
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| Research Institution | Beppu University Junior College (2011)
Kansai Medical University (2009-2010) |
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Principal Investigator |
HASE Makoto 別府大学短期大学部, 准教授 (50425203)
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| Co-Investigator(Kenkyū-buntansha) |
SASAKI Yutaka 関西医科大学, 医学部, 講師 (80425066)
ARAKI Satohiko 名古屋大学, 理学(系)研究科(研究院), 講師 (80242808)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 細胞間接着 / GPCRs / 幹細胞 / 細胞内情報伝達系 / G蛋白質共役型受容体 / 細胞接着 |
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| Research Abstract |
The differentiation and maintenance of stem cells are integral to the development and homeostasis of many tissues, including the tumors. These stem cells often live in specialized functional areas, called niches. However, the molecular mechanisms of stem cells and niches regulatory function remain unclear. Here, using human hematopoietic stem cell(HSC), and cancer stem cell compartment of squamous cancer cell strain A431 cell, we evaluated the level of expression of TM7XN1 and other G protein-coupled receptors(GPCRs) on stem cells, and analyzed how this affects their interaction with niche.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] Interleukin-8 enhances the proliferation and angiogenic activity of umbilical cord blood-derived outgrowth endothelial cells in vitro2011
Author(s)
Kimura T, Kohno H, Matsuoka Y, Murakami M, Nakatsuka R, Hase M, Yasuda K, Uemura Y, Sasaki Y, Fukuhara S, Sonoda Y
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Journal Title
Cell Biol Int
Volume: 35(3)
Pages: 201-208
Related Report
Peer Reviewed
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[Presentation] マウス骨髄造血幹/前駆細胞はCXCR4低発現である2009
Author(s)
Sasaki Y, Matsuoka Y, Toyohara T, Hase M, Nakatsuka R, Uemura Y, Sonoda Y
Organizer
第71回日本血液学会総会
Place of Presentation
京都(国立京都国際会館)
Year and Date
2009-10-25
Related Report
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[Presentation] Modification of IL-12p70 and IL-23 balance in dendritic cells by Valpha24 invariant NKT cells2009
Author(s)
Uemura Y, Liu T, Narita Y, Suzuki M, Nakatsuka R, Hirosawa N, Matsuoka Y, Murakami M, Hase M, Kohno H, Sasaki Y, Sakamoto Y, Senju S, Sonoda Y
Organizer
第71回日本血液学会総会
Place of Presentation
京都(国立京都国際会館)
Year and Date
2009-10-23
Related Report
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