Investigation of survival system of marine invertebrates via bioactive marine natural products

• Project/Area Number: 21603006
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Chemical biology
• Research Institution: The University of Tokyo
• Principal Investigator: FUKUZAWA Seketsu 東京大学, 大学院・理学系研究科, 助教 (40321806)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 活性天然物 / アフィニティーカラム / リテラジンB / カリクリンA / オカダ酸 / 結合タンパク質

Research Abstract

Okadaic acid(OA) is a marine polyether cytotoxin, which was isolated from the marine sponge, Halichondria okadai. The crystal structure of okadaic acid binding protein 2. 1(OABP 2. 1) in complex with OA was solved.

Research Products

• [Journal Article] The effect of SDS and anion exchange silica gel on MALDI-MS analysis of proteins. (2010)
  • Author(s): Asanuma, M.; Fukuzawa, S.; Matsuda, T.; Hirota, H.
  • Journal Title: Rapid Common. Mass Spectrom. 23 Pages: 1647-1653
  • Peer Reviewed
• [Journal Article] Skeletal protein protection : the mode of action of an anti-osteoporotic marine alkaloid, norzoanthamine. (2009)
  • Author(s): Kinugawa, M.; Fukuzawa, S.; Tachibana, K.
  • Journal Title: J.Bone Miner.Metab. 27 Pages: 303-314
  • NAID: 10025337339
  • Peer Reviewed
• [Journal Article] Distribution and possible function of the marine alkaloid, norzoanthamine, in the zoanthid Zoanthus sp. using MALDI imaging mass spectrometry. (2009)
  • Author(s): Genji, T.; Fukuzawa, S.; Tachibana, K.
  • Journal Title: Mar.Biotechnol. 12 Pages: 81-87
  • Peer Reviewed
• [Presentation] 伊豆半島産群体ホヤRitteralla tokioka由来リテラジンBの結合タンパク質の探索 (2012)
  • Author(s): 前田高宏・福沢世傑・橘和夫
  • Organizer: 日本化学会第92年会
  • Place of Presentation: 横浜
  • Year and Date: 2012-03-27
• [Presentation] 伊豆半島産群体ホヤRitterella tokioka由来リテラジンBの、同ホヤでの結合タンパク質の探索 (2011)
  • Author(s): 福永泰隆・前田高宏・福沢世傑・橘和夫
  • Organizer: 日本化学会第91年会
  • Place of Presentation: 横浜
  • Year and Date: 2011-03-29
• [Presentation] 海綿Discodermia calyx由来カリクリンAの同海綿での結合タンパク質の探索 (2011)
  • Author(s): 三宅晴子・福沢世傑・橘和夫
  • Organizer: 日本化学会第91年会
  • Place of Presentation: 横浜
  • Year and Date: 2011-03-28
• [Presentation] Structural elucidation of okadaic acid binding protein 2. 1 (2010)
  • Author(s): Seketsu Fukuzawa, Marie Makino, Koichiro Kodama, Haruhiko Ehara, Takuhiro Ito, Shun-ichi Sekine, Shigeyuki Yokoyama, Kazuo Tachibana
  • Organizer: The 2010 International Chemical Congress of Pacific Basin Societies
  • Place of Presentation: Honolulu, Hawaii, USA
  • Year and Date: 2010-12-18
• [Presentation] クロイソカイメン由来オカダ酸結合タンパク質OABP2. 1のX線結晶構造解析 (2010)
  • Author(s): 福沢世傑
  • Organizer: 第5回化学生態学研究会
  • Place of Presentation: 函館
  • Year and Date: 2010-06-12
• [Presentation] クロイソカイメン由来オカダ酸結合タンパク質OABP2.1のX線結晶構造解析 (2010)
  • Author(s): 福沢世傑
  • Organizer: 第5回化学生態学研究会
  • Place of Presentation: 函館
  • Year and Date: 2010-06-12
• [Presentation] Symbiotic relationship through norzoanthamine, an anti-osteoporotic marine alkaloid (2010)
  • Author(s): Seketsu Fukuzawa
  • Organizer: The 17th NTU-SNT-UT Chemistry Symposium
  • Place of Presentation: Taipei, ROC
  • Year and Date: 2010-05-14
• [Presentation] オカダ酸結合タンパク質OABP2. 1の構造解析 (2010)
  • Author(s): 牧野満理瑛、児玉公一郎、福沢世傑、関根俊一、横山茂之、橘和夫
  • Organizer: 日本化学会第90年会
  • Place of Presentation: 吹田
  • Year and Date: 2010-03-26
• [Presentation] 海洋天然化合物生産微生物の同定 (2009)
  • Author(s): 福沢世傑
  • Organizer: 第2回早稲田大学総合研究機構ケミカルバイオロジー研究所シンポジウム、動的平衡としての微生物共生系と天然物化学
  • Place of Presentation: 東京
  • Year and Date: 2009-12-25
• [Remarks]
  • URL: http://www.chem.s.u-tokyo.ac.jp/users/natural/
• [Remarks]
  • URL: http://www.chem.s.u-tokyo.ac.jp/users/natural/research.html
• [Remarks]
  • URL: http://www.chem.s.u-tokyo.ac.jp/users/natural/research.html
• [Remarks]
  • URL: http://www.chem.s.u-tokyo.ac.jp/users/natural/research.html