Elucidation of new anti-tumor and anti-HIV target proteins by using probe molecules derived from bioactive natural products
Project/Area Number |
21603009
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Chemical biology
|
Research Institution | Kyoto Pharmaceutical University |
Principal Investigator |
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | プローブ分子 / 抗HIV / 抗がん / 天然物 / 標的蛋白 |
Research Abstract |
Elucidation of new anti-tumor and anti-HIV target proteins has been investigated by using the probe molecules derived from the bioactive natural products, peumusolide and osthol, found by our group. Consequently, we disclosed the respective probe molecules not only containing the diardine-biotin unit to capture and purify target proteins under photo-irradiation but also inhibiting nuclear-export of MEK and Rev potently.
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Report
(4 results)
Research Products
(13 results)