| Project/Area Number |
21603012
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical biology
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| Research Institution | Tohoku Pharmaceutical University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
NAKAZAWA Takahiro 東北薬科大学, 薬学部, 講師 (60296019)
UKAI Kazuyo 東北薬科大学, 薬学部, 助教 (60433512)
YAMAZAKI Hiroyuki 東北薬科大学, 薬学部, 助手 (70525344)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | ホヤ / アルカロイド / 抗癌活性 / 抗炎症活性 / 生物活性発現機構 / TNF-α / NF-κB / α-カルボリン |
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| Research Abstract |
Lissoclibadins, anticancer alkaloids isolated from an Indonesian colonial ascidian, induced an apoptosis(programmed cell death) to cancer cells by increasing the activity of caspases, important proteins for the induction of an apoptosis. Two alkaloids were isolated from a sponge collected in Iriomote Is., Okinawa as cytotoxic components, which induced an apoptosis to cancer cells. DDMG-1, an alkaloid isolated from an Indonesian solitary ascidian, decreased the production of TNF-α, an inflammatory cytokine that over produced in rheumatism and cancer, and the molecular mechanism of action was elucidated. Three components, which inhibited the production of TNF-α, were isolated from an Indonesian soft coral.
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