Effects of visceral sensitivity on brain processing of stress stimuli in childhood

• Project/Area Number: 21610003
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Children studies (Studies of environment on children)
• Research Institution: Tohoku University
• Principal Investigator: WATANABE Satoshi 東北大学, 大学院・医学系研究科, 非常勤講師 (40431506)
• Co-Investigator(Kenkyū-buntansha): KANAZAWA Motoyori 東北大学, 大学院・医学系研究科, 講師 (70323003) ; FUKUDO Shin 東北大学, 大学院・医学系研究科, 教授 (80199249)
• Project Period (FY): 2009 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 内臓知覚過敏 / 過敏性腸症候群 / 小児腹痛 / 養育態度 / 注意制御 / 事象関連電位 / 聴覚誘発電位 / ストレス感受性 / 行動抑制 / 機能性腹痛 / 情動制御 / ストレス

Research Abstract

In the present study, we investigated the brain processing of stress stimuli with functional abdominal pain features of children. Children aged seven and their mothers (200 pairs) participated. Brainstem auditory evoked potential (BAEP) were triggered by 75 dB click sounds. Event-related pontential (ERP) were recorded while children performed a modified Go/Nogo task. The N2 peak of ERP in the abdominal pain group had significantly shorter peak latency than control. The present ERP findings suggest the possibility that relevant viscerosensory information is rapidly conveyed to the stress-related brain network and is processed by the biased attention of children with functional abdominal pain.

Research Products

• [Journal Article] Enhanced auditorybrainstem response and parental bonding style in children with gastrointestinal symptoms (2012)
  • Author(s): Seino S, Watanabe S, Ito N, Sasaki K, Shoji K, Miura S, Kozawa K, Nakai K, Sato H, Kanazawa M, Fukudo S
  • Journal Title: PLoS One Volume: 7(3) Issue: 3 Pages: e32913-e32913
  • DOI: 10.1371/journal.pone.0032913
  • Peer Reviewed
• [Journal Article] Brain responses to cardiac electrical stimulation: a new EEG method for evaluating cardiacsensation (2012)
  • Author(s): Suzuki H, Hirose M, Watanabe S, Fukuda K, Fukudo S, Shimokawa H
  • Journal Title: Tohoku J Exp Med Volume: 226(1) Pages: 3-10
  • Peer Reviewed
• [Journal Article] Altered cognitive function of prefrontal cortex during error feedback in patients with irritable bowel syndrome, based on FMRI and dynamic causal modeling (2012)
  • Author(s): Aizawa E, Sato Y, Kochiyama T, Saito N, Izumiyama M, Morishita J, Kanazawa M, Shima K, Mushiake H, Hongo M, Fukudo S
  • Journal Title: Gastroenterology Volume: 143(5) Issue: 5 Pages: 1188-1198
  • DOI: 10.1053/j.gastro.2012.07.104
  • Peer Reviewed
• [Journal Article] Brain responses to cardiac electrical stimulation: a new EEG method for evaluating cardiac sensation. (2012)
  • Author(s): Suzuki H
  • Journal Title: Tohoku J Exp Med Volume: 226(1) Pages: 3-10
  • Peer Reviewed
• [Journal Article] Brain responses to cardiac electrical stimulation : a new EEG method for evaluating cardiac sensation (2012)
  • Author(s): Suzuki H, et al
  • Journal Title: Tohoku J.Exp.Med. Volume: 226 Pages: 3-10
  • Peer Reviewed
• [Journal Article] Enhanced Auditory Brainstem Response and Parental Bonding style in Children with Gastrointestinal Symptoms (2012)
  • Author(s): Seino S, et al
  • Journal Title: PLoS ONE Volume: 7(3)
  • Peer Reviewed
• [Journal Article] Effect of 5-HT(4)receptor agonist mosapride citrate on rectosigmoid sensorimotor function in patients with irritable bowel syndrome (2011)
  • Author(s): Kanazawa M, Watanabe S, Tana C, Komuro H, Aoki M, Fukudo S.
  • Journal Title: Neurogastroenterol Motil Volume: 23 Issue: 8 Pages: 754-759
  • DOI: 10.1111/j.1365-2982.2011.01732.x
  • Peer Reviewed
• [Journal Article] Effect of repetitive transcranial magnetic stimulation on rectal function and emo tion in humans (2011)
  • Author(s): Aizawa Y, Morishita J, Kano M, Mori T, Izumi SI, Tsutsui K, Iijima T, Kanazawa M, Fukudo S.
  • Journal Title: J Gastroenterol Volume: 46 Issue: 9 Pages: 1171-1180
  • DOI: 10.1007/s00535-011-0423-9
  • Peer Reviewed
• [Journal Article] Effect of 5-HT(4) receptor agonist mosapride citrate on rectosigmoid sensorimotor function in patients with irritable bowel syndrome (2011)
  • Author(s): Kanazawa M, et al
  • Journal Title: Neurogastroenterology and motility Volume: 23
  • Peer Reviewed
• [Journal Article] Site-specific differences in central processing of visceral stimuli from the rectum and the descending colon in men (2010)
  • Author(s): Kanazawa M, et al.
  • Journal Title: Neurogastroenterology and motility 22(2) Pages: 173-180
  • Peer Reviewed
• [Journal Article] Brain activation associated with changes in heart rate, heart rate variability, and plasma catecholamines during rectal distention (2009)
  • Author(s): Suzuki H, et al.
  • Journal Title: Psychosomatic Medicine 71(6) Pages: 619-626
  • Peer Reviewed
• [Journal Article] Impact of serotonin transporter gene polymorphism on brain activation by colorectal distention (2009)
  • Author(s): Fukudo S, et al.
  • Journal Title: Neuroimage 47(3) Pages: 946-951
  • Peer Reviewed
• [Presentation] 塩酸クロミプラミンが消化管刺激誘発性局所脳活動に及ぼす影響 (2010)
  • Author(s): 伊藤菜見子, 他
  • Organizer: 第51回日本心身医学会総会ならびに学術講演会
  • Place of Presentation: 仙台
• [Presentation] 過敏性腸症候群におけるSet Shift時の脳活動 (2010)
  • Author(s): 相澤恵美子, 他
  • Organizer: 第51回日本心身医学会総会ならびに学術講演会
  • Place of Presentation: 仙台
• [Presentation] 消化器症状を伴う小児の聴性脳幹反応と母親の養育態度の特徴 (2010)
  • Author(s): 清野静, 他
  • Organizer: 第51回日本心身医学会総会ならびに学術講演会
  • Place of Presentation: 仙台
• [Presentation] 繰り返された消化管刺激に対する脳活動 (2010)
  • Author(s): 濱口豊太, 他
  • Organizer: 第51回日本心身医学会総会ならびに学術講演会
  • Place of Presentation: 仙台
• [Presentation] Auditory brain responsein children with irritabowel syndrome (2009)
  • Author(s): Seino S, et al
  • Organizer: The 32nd Annual meeting of the Japan Neuroscience of Society
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-25
• [Presentation] Child functional abdominal pain and neurophysiological development of emotion regulation in7-year-old children (2009)
  • Author(s): Watanabe S, et al
  • Organizer: The 32nd Annualmeeting of the Japan Neuroscience of Society
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-25
• [Presentation] 消化器症状を伴う小児の聴性脳幹反応と母親の養育態度の特徴 (2009)
  • Author(s): 清野静, 他
  • Organizer: 第11回日本神経消化器病学会
  • Place of Presentation: 仙台
  • Year and Date: 2009-09-25
• [Presentation] Auditory brain response in children with irritabowel syndrome (2009)
  • Author(s): 清野静, 他
  • Organizer: The 32nd Annual meeting of the Japan Neuroscience of Society
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-25
• [Presentation] Child functional abdominal pain and neurophysiological development of emotion regulation in 7-year-old children (2009)
  • Author(s): 渡辺諭史, 他
  • Organizer: The 32nd Annual meeting of the Japan Neuroscience of Society
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-25
• [Presentation] 小児機能性腸障害と脳幹刺激反応性ならびに両親の養育態度の関連 (2009)
  • Author(s): 清野静, 他
  • Organizer: 第68回日本心身医学会東北地方会
  • Place of Presentation: 福島
  • Year and Date: 2009-09-12
• [Presentation] 小児過敏性腸症候群における行動制御の神経生理学的異常 (2009)
  • Author(s): 渡辺諭史, 他
  • Organizer: 第68回日本心身医学会東北地方会
  • Place of Presentation: 福島
  • Year and Date: 2009-09-12
• [Book] 暗示効果.In.ストレス科学辞典.(編)日本ストレス学会 (2011)
  • Author(s): 渡辺諭史
  • Publisher: 実務出版社
• [Book] 催眠.In.ストレス科学辞典.(編)日本ストレス学会 (2011)
  • Author(s): 渡辺諭史
  • Publisher: 実務出版社
• [Book] 暗示効果in日本ストレス学会ストレス科学辞典((財)パブリックヘルスリサーチセンター(監修)) (2011)
  • Author(s): 渡辺諭史
  • Total Pages: 38
  • Publisher: 実務教育出版社
• [Book] 催眠in日本ストレス学会ストレス科学辞典((財)パブリックヘルスリサーチセンター(監修)) (2011)
  • Author(s): 渡辺諭史
  • Publisher: 実務教育出版社