| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Research Abstract |
Olfactory bulbectomy(OBX) animals are considered a putative model of depression. In this study, we investigated the change of maternal behavior in OBX mice. The number of OBX mother's pups significantly decreased per day. The causes were suggested that OBX disrupted both the onset of maternal behavior and reward function. Furthermore, the behavioral data demonstrated that the disruption of maternal behavior in OBX mothers is related to depressed dopaminergic function in the central nervous system induced by OBX. However, our findings concerning dopaminergic function suggest that the disruptions in OBX mice are not simply due to changes in tyrosine hydroxylase levels or dopamine receptor number in the nucleus accumbens.
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