Microtomographic analysis of biological tissues
| Project/Area Number |
21611009
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical Physics/Radiological Technology
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| Research Institution | Tokai University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | 生体組織 / 三次元構造 / マイクロトモグラフィ / 神経回路 / マイクロＣＴ / マイクロトモグラフィー / マイクロCT |
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| Research Abstract |
Computed tomography (CT) is a noninvasive technique for visualizing three-dimensional structures. Tomographic slices are reconstructed from a series of projection images acquired by a rotational scan. The application of x-ray microscopic approaches to CT analysis has led to the visualization of the three-dimensional microstructures of biological samples. We determined three-dimensional cellular and subcellular structure of human cerebral cortex stained with high atomic-number probes. The obtained structure indicated that the neuronal networks and capillary vessel architectures were visualized as the three-dimensional distribution of x-ray absorption coefficients. The capillary microstructures were used as a template to fabricate a resin model of capillary blood vessels. These results indicated that x-ray microtomography is a potential method of visualizing human tissue structures.
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Report
(5 results)
Research Products
(44 results)
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[Journal Article]2009
Author(s)
R.Mizutani, A.Takeuchi, K.Uesugi, S.Takekoshi, R.Y.Osamura, Y.Suzuki
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Journal Title
Three-dimensional microstructural analysis of human brain tissue by using synchrotron radiation microtomographs. In Handbook on White Matter(Nova Science Publishers)(eds. Westland, T.B. & Calton, R.N.)
Pages: 247-277
Related Report
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[Presentation] X線マイクロトモグラフィ法によるヒト大脳皮質の三次元構造解析2012
Author(s)
雑賀里乃,伊藤安希,竹腰進,中村直哉,新井誠,大島健一,糸川昌成,竹内晃久,上杉健太朗,鈴木芳生,水谷隆太
Organizer
第85回日本生化学会大会
Place of Presentation
福岡国際会議場
Year and Date
2012-12-15
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