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A study of the clinical features of PIB-negative dementia patients in amyloid PET

Research Project

Project/Area Number 21613007
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Non-invasive neuroimaging
Research InstitutionOsaka City University

Principal Investigator

SHIMADA Hiroyuki  大阪市立大学, 大学院・医学研究科, 准教授 (90254391)

Co-Investigator(Kenkyū-buntansha) ATAKA Suzuka  大阪市立大学, 大学院・医学研究科, 研究医 (40549755)
MIKI Takami  大阪市立大学, 大学院・医学研究科, 教授 (90174002)
WATANABE Yasuyoshi  大阪市立大学, 大学院・医学研究科, 特任教授 (40144399)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
KeywordsアミロイドPET / アルツハイマー病 / バイオマーカー / アミロイド陰性認知症 / アミロイドペット / アルツハイマー型認知症 / 高齢者タウオパチー
Research Abstract

Background/Aims : We previously found that some cases of clinically diagnosed Alzheimer's disease(AD) were rated as Pittsburgh compound-B(PiB)-negative by amyloid imaging(ie, cases of PiB-negative dementia). These may involve diseases that do not have pathological amyloid accumulation in the brain, such as dementia with Lewy bodies(DLB), frontotemporal lobar degeneration(FTLD), argyrophilic grain disease(AGD), and neurofibrillary tangle-predominant dementia(NFTD), as well as AD itself. The present study was designed to analyze the clinical features of PiB-negative dementia patients in detail with cerebrospinal fluid(CSF) analysis and neuroradiological tests. Methods : Of the 64 cases of clinically diagnosed AD, 14 were rated PiB-negative with PiB-positron emission tomography(PET). Eleven of these were further analyzed using CSF biomarker levels and findings from magnetic resonance imaging(MRI), fluorodeoxyglucose(FDG)-PET,<123>^I-metaiodobenzylguanidine(MIBG) myocardial scintigraphy, and voxel-based morphometry(VBM). Results : When examined by<123>^I-MIBG myocardial scintigraphy, the PiB-negative dementia group differed slightly from the healthy control group in both the early and delayed phases, and the H/M ratio was significantly higher in the PiB-negative dementia group than in the DLB group. Analyses of CSF biomarkers and MRI and FDG-PET findings among the 11 cases of PiB-negative dementia suggested AGD in 3 cases, FTLD in 3 cases, NFTD in 1 case, and AD in 2 cases. Conclusion : PiB-negative dementia is unlikely to include DLB, while it most likely includes diseases of tauopathy, such as FTLD, AGD, and NFTD. A better understanding of PiB-negative dementia is expected to further improve the accuracy of clinical diagnosis of AD.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (30 results)

All 2011 2010 2009

All Journal Article (15 results) (of which Peer Reviewed: 14 results) Presentation (15 results)

  • [Journal Article] Genetic polymorphysms involved in dopaminergic neurotrasmission and risk for Parkinson's disease in a Japanease population2011

    • Author(s)
      Kiyohara, Y. Miyake, M. Koyanagi, T. Fujimoto, S. Shirasawa, K. Tanaka, W Fukushima, S. Sasaki, Y. Tsuboi, T. Yamada, T. Oeda, H. Shimada, et al.
    • Journal Title

      BMC Neurology C

      Volume: 11 Pages: 89-97

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Two cases of dementias with motor neuron disease evaluated by Pittsburgh compound B-positron emission tomography2011

    • Author(s)
      Y. Yamakawa, H. Shimada, S. Ataka, A. Tamura, H. Masaki, H. Naka, T. Tsutada, A. Nakanishi, . Shiomi, Y. Watanabe, T. Miki
    • Journal Title

      Neurological scien

      Volume: 33 Pages: 87-92

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] PiB-negative dementia-a possibility of misdiagnosis of patients with non-Alzheimer's disease(AD) type dementia as having AD.2011

    • Author(s)
      H. Shimada, S. Ataka, J. Takeuchi, H. Mori, S. Wada, Y. Watanabe, T. Miki
    • Journal Title

      J Geriatric Psy Nerulogy

      Volume: 24 Pages: 123-126

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical Course of Patients with Familial Early-Onset Alzheimer's Disease Potentially Lacking Senile Plaques Bearing the E693Delta Mutation in Amyloid Precursor Protein2011

    • Author(s)
      H. Shimada, S. Ataka, T. Tomiyama, H. Takechi, H. Mori, T. Miki.
    • Journal Title

      Dement Geriatr Cogn Disord

      Volume: 32 Pages: 45-54

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dietary patterns and risk of Parkinson's disease : a case-control study in Japan2011

    • Author(s)
      Hitomi Okuboa, Yoshihiro Miyake, Satoshi Sasakia, Kentaro Murakami, Keiko Tanaka, Wakaba Fukushima, Chikako Kiyoharaf Yoshio Tsuboi, Tatsuo Yamada, Tomoko Oedah, Hiroyuki Shimadai, et al.
    • Journal Title

      European J Neurol

      Volume: 11 Pages: 89-97

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pittsburgh Compound B-Negative Dementia-A Possibility of Misdiagnosis of Patients With Non-AlzheimerDisease-Type Dementia as Having AD2011

    • Author(s)
      Shimada H, Ataka S, Takeuchi J, Mori H, Wada Y, Watanabe Y, Miki T
    • Journal Title

      Journal of Geriatric Psychiatry and Neurology

      Volume: 24 Issue: 3 Pages: 123-126

    • DOI

      10.1177/0891988711409410

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic polymorphysms involved in dopaminergic neurotrasmission and risk for Parkinson's disease in a Japanease population2011

    • Author(s)
      O.Kiyouaia, T.Miyake, M.Koyanagi, T.Fujimoto, S.Shirasawa, K.Tanaka, W.Fukushima, S.Sasaki, Y.Tsuboi, T.Yamada, T.Oeda, H.Shimada, et al
    • Journal Title

      BMC Neurology

      Volume: 11 Issue: 1 Pages: 89-97

    • DOI

      10.1186/1471-2377-11-89

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Two cases of dementias with motor neuron disease evaluated by Pittsburgh compound B-positron emission tomography2011

    • Author(s)
      Yamakawa Y, Shimada H, Ataka S, Tamura A, Masaki H, Naka H, Tsutada T, Nakanishi A, Shiomi S, Watanabe Y, Miki T.
    • Journal Title

      Neurol Sci

      Volume: (Epub ahead of print)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PiB -negative dementia -a possibility of misdiagnosis of patients with non-Alzheimer's disease (AD) type dementia as having AD2011

    • Author(s)
      H.Shimada, S.Ataka, J.Takeuchi, H.Mori, S.Wada, Y.Watanabe, T.Miki
    • Journal Title

      J Geriatric Psy Nerulogy

      Volume: (In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A mouse model of amiloidβoligomers : their contribution to synaptic alteration, abnoraml tau phosphorylation, glial activation2010

    • Author(s)
      Takami Tomiyama, Shogo Matsuyama, Hiroyuki Iso, Tomohiro Umeda, Hiroshi Takuma, Kiyouhisa Ohnishi, Kenichi Ishibashi, Rie Teraoka, Naomi Sakama, Takenari Yamashita, Kazuchika Nishitsuji, Kazuhiro Ito, Hiroyuki Shimada, et al.
    • Journal Title

      J Neuroscience

      Volume: 30(14) Pages: 4845-4856

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] アミロイドイメージングをめぐる問題点-アルツハイマー病以外のデータ-2010

    • Author(s)
      嶋田裕之、安宅鈴香、三木隆己
    • Journal Title

      Cognition and Dementia

      Volume: 9 Pages: 33-37

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Neuropsychological Status of Elderly Patients with Diabetes Mellitus.2010

    • Author(s)
      Hiroyuki Shimada
    • Journal Title

      Diabetes Research and Clinical Practice 87

      Pages: 224-227

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neuropsychological Status of Elderly Patients with Diabetes Mellitus2009

    • Author(s)
      Hiroyuki Shimada, Takami Miki, Akiko Tamura, Suzuka Ataka, Masanori Emoto, Yoshiki Nishizawa
    • Journal Title

      Diabetes Research and Clinical Practice

      Pages: 224-227

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] High strial amyloidβ-peptide deposition across differential Alzheimer disease mutation types2009

    • Author(s)
      Victor L. Villemagne, Suzuka Ataka, Toshiki Mizuno, William S. Brooks, Yasuhiro Wada, Masaki Kondo, Gareth Jones, ; Yasuyoshi Watanabe, ; Rachel Mulligan, Masanori Nakagawa, Takami Miki, Hiroyuki Shimada, et al.
    • Journal Title

      Arch Neurol

      Volume: 66 Pages: 1537-1544

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] High strial amyloid β-peptide deposition across differential Alzheimer disease mutation types2009

    • Author(s)
      Victor L.Villemagne, et al
    • Journal Title

      Archives of Neurology 66

      Pages: 1537-1544

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Intravenous immunoglobulin improved cognitive functions in patients with Alzheimer's disease without any changes in PIB retention in the brain2011

    • Author(s)
      Takahiko Tokuda, Masaki Kondo, Takashi Kasai, Yoko Oishi, Suzuka Ataka, Hiroyuki Shimada, Takami Miki, Hiroshi Mori, and Masanori Nakagawa
    • Place of Presentation
      フランス、パリ
    • Year and Date
      2011-07-18
    • Related Report
      2011 Final Research Report
  • [Presentation] Follow-up study of PiB negative dementia International Conference on Alzheimer's Disease2011

    • Author(s)
      Suzuka Ataka, Hiroyuki Shimada, Jun Takeuchi, Akitoshi Takeda, Akiko Tamura, Motokatsu Kanemoto, Kazuhiro Ito, Jyoji Kawabe, Kazuhiro Takahashi, Yasuhiro Wada, Aki Nakanishi, Tsuyoshi Tsutada, Susumu Shiomi, Hiroshi Mori, Yasuyoshi Watanabe, Takami Miki
    • Place of Presentation
      フランス、パリ
    • Year and Date
      2011-07-17
    • Related Report
      2011 Final Research Report
  • [Presentation] Intravenous immunoglobulin improved cognitive functions in patients with Alzheimer's disease without any changes in PIB retention in the brain2011

    • Author(s)
      Takaiko Tokoua, Masaki Konuo, Takashi Kasai, Yoko Oishi, Suzuka Ataka, Hiroyuki Shimada, et al
    • Organizer
      International Conference on Alzheimer's Disease
    • Place of Presentation
      Paris, France
    • Year and Date
      2011-07-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] Follow-up study of PiB negative dementia2011

    • Author(s)
      Suzuka Ataka, Hiroyuki Shimada, Jun Takeuchi, Akitoshi Takeda, Akiko Tamura, et al
    • Organizer
      International Conference on Alzheimer's Disease
    • Place of Presentation
      Paris, France
    • Year and Date
      2011-07-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] 1231-MIBG心筋シンチグラフィーによるPiB陰性認知症の鑑別診断の検討2010

    • Author(s)
      竹内潤, 安宅鈴香, 嶋田裕之, 河連譲治勢, 和国康弘, 蔦田強司, 塩見進, 中西亜紀, 三木隆己, 森啓, 渡遵恭良
    • Organizer
      第29回日本認知症学会学術集会
    • Place of Presentation
      名古屋(ウィンク愛知)
    • Year and Date
      2010-11-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] Both PiB positive and negative MCIs have similar risk of conversion to dementia2010

    • Author(s)
      S.Ataka, H.Shimada, J.Takeuchi, J.Kawabe, K.Takahashi, Y Wada, A.Nakanish, T.Tsutada, S.Shiomi, H.Mori, Y.Watanabe, T.Miki
    • Organizer
      International Conference of Arzheimer's disease2011
    • Place of Presentation
      米国 ホノルル
    • Year and Date
      2010-07-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] Characteristics of Neuropsychological Findings of Clinically Diagnosed Alzheimer's Disease and Mild Cognitive Impairment Patients Who Show Negative Results in Amyloid Imaging2010

    • Author(s)
      H.Takechi, S.Ataka, M.Nishida., T.Miki, H.Shimada
    • Organizer
      ICAD 2010 (International Conference of Arzheimer's disease)
    • Place of Presentation
      米国 ホノルル
    • Year and Date
      2010-07-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] Characteristics of Neuropsychological Findings of Clinically Diagnosed Alzheimer's Disease and Mild Cognitive Impairment Patients Who Show Negative Results in Amyloid Imaging2010

    • Author(s)
      H. Takeuchi, S. Ataka, M. Nishida, T. Miki, H. Shimada
    • Organizer
      Alzheimer's Association International Conference on Alzheimer's Disease
    • Place of Presentation
      ホノルル、ハワイ
    • Year and Date
      2010-07-11
    • Related Report
      2011 Final Research Report
  • [Presentation] Both PiB positive and negative MCIs have similar risk of conversion to dementia2010

    • Author(s)
      Suzuka Ataka, Hiroyuki Shimada, Jun Takeuchi, Jyoji Kawabe, Kazuhiro Takahashi, Yasuhiro Wada, Aki Nakanishi, Tsuyoshi Tsutada, Susumu Shiomi, Hiroshi Mori, Yasuyoshi Watanabe, Takami Miki
    • Organizer
      Alzheimer's Association International Conference on Alzheimer's Disease
    • Place of Presentation
      ホノルル、ハワイ
    • Year and Date
      2010-07-11
    • Related Report
      2011 Final Research Report
  • [Presentation] 医療機関を受診する軽度認知障害(MCI)はPiB-PETでのアミロイド集積の有無にかかわらず認知症へ移行するリスクが高い2010

    • Author(s)
      安宅鈴香、嶋田裕之、竹内潤, 他
    • Organizer
      第52回日本老年病学会
    • Place of Presentation
      神戸(神戸国際会議場・神戸商工会議所・神戸ポートピアホテル)
    • Year and Date
      2010-06-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] Biochemical analysis of intracellular oligomers2009

    • Author(s)
      Yamamoto K. Shimada H. Mori H.
    • Organizer
      Neuroscience
    • Place of Presentation
      米国、シカゴ
    • Year and Date
      2009-11-13
    • Related Report
      2011 Final Research Report
  • [Presentation] ^<11>C-PIB-PET imaging and cognitive statement in Alzheimer disease, mild cognitive impairment, and healthy aging : 1-1.5 Year follow-up study.2009

    • Author(s)
      Suzuka Ataka
    • Organizer
      12th International conference of Alzheimer's disease
    • Place of Presentation
      オーストリア、ウィーン
    • Year and Date
      2009-07-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] ^<11> C-PIB-PET imaging and cognitive statement in Alzheimer disease, mild cognitive impairment, and healthy aging : 1-1.5 Year follow-up study2009

    • Author(s)
      Suzuka Ataka, Hiroyuki Shimada, Jun Takeuchi, Jyoji Kawabe, Makoto Shigematsu, Yasuhiro Wada, Aki Nakanishi, Tsuyoshi Tsutada, Susumu Shiomi, Hiroshi Mori, Yasuyoshi Watanabe, Takami Miki
    • Organizer
      12th International conference of Alzheimer's disease
    • Place of Presentation
      オーストリア、ウィーン
    • Year and Date
      2009-07-13
    • Related Report
      2011 Final Research Report
  • [Presentation] PiB negative Dementia.-Pitfall of clinical diagnosis of Alzheimer's disease2009

    • Author(s)
      H. SHIMADA, S. ATAKA, J. TAKEUCHI, A. NAKANISHI, J. KAWABE, S. SHIOMI, H. MORI, T. MIKI, M. SHIGEMATSU, Y. WADA, Y. WATANABE
    • Organizer
      12th International conference of Alzheimer's disease
    • Place of Presentation
      オーストリア、ウィーン
    • Year and Date
      2009-07-12
    • Related Report
      2011 Final Research Report
  • [Presentation] PiB negative Dementia -Pitfall of clinical diagnosis of Alzheimer's disease2009

    • Author(s)
      H.SHIMADA
    • Organizer
      12th International conference of Alzheimer's disease
    • Place of Presentation
      オーストリア、ウィーン
    • Year and Date
      2009-07-12
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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