Functional and anatomical representation in the brain for motor recovery

• Project/Area Number: 21613011
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Non-invasive neuroimaging
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: HAYASHI Takuya 独立行政法人理化学研究所, 分子プローブ機能評価研究チーム, 副チームリーダー (50372115)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 拡散 / テンソル / 線維連絡 / 運動機能 / 回復 / 可塑性 / 運動 / MRI / 拡散テンソル / 運動機能回復 / 錐体路 / 錐体外路 / 線維連絡性 / 脳損傷

Research Abstract

After brain injury, an intrinsic ability to recover brain function, particularly for executing motor behaviors, is quite limited. Understanding the neural mechanism of motor recovery may facilitate development of therapeutics or rehabilitation. In this study, we performed the functional brain imaging in stroke patients and in an animal model of motor dysfunction-recovery, and identified several brain regions which showed functional changes after injury. These findings may shed light on a therapeutic model of motor recovery.

Research Products

• [Journal Article] Prolonged Maturation Culture Favors a Reduction in the Tumorigenicity and the Dopaminergic Function of Human ESC-Derived Neural Cells in a Primate Model of Parkinson's Disease (2012)
  • Author(s): Doi D, Morizane A, Kikuchi T, Onoe H, Hayashi T, et al
  • Journal Title: Stem Cells
• [Journal Article] Effects of patient movement on measurements of myocardial blood flow and viability in resting(15) O-water PET studies (2012)
  • Author(s): Koshino K, Watabe H, Enmi J, Hirano Y, Zeniya T, Hasegawa S, Hayashi T, et al
  • Journal Title: Journal of Nuclear Cardiology
• [Journal Article] Quantification of regional cerebral blood flow in rats using an arteriovenous shunt and micro-PET (2012)
  • Author(s): Ose T, Watabe H, Hayashi T, et al
  • Journal Title: Nuclear Medicine and Biology
• [Journal Article] An Alteration in the Lateral Geniculate Nucleus of Experimental Glaucoma Monkeys : In vivo Positron Emission Tomography Imaging of Glial Activation (2012)
  • Author(s): Shimazawa M, Ito Y, Inokuchi Y, Yamanaka H, Nakanishi T, Hayashi T, et al
  • Journal Title: PLoS ONE Volume: 7(1)
• [Journal Article] Three-dimensional quantitation of regional cerebral blood flow in mice using a high-resolution pinhole SPECT system and(123) I-iodoamphetamine (2011)
  • Author(s): Zeniya T, Watabe H, Hayashi T, et al
  • Journal Title: Nucl. Med. Biol Volume: 38(8) Pages: 1157-1164
• [Journal Article] Sensitivity of kinetic macro parameters to changes in dopamine synthesis, storage, and metabolism : A simulation study for[(18) F] FDOPA PET by a model with detailed dopamine pathway (2011)
  • Author(s): Matsubara K, Watabe H, Kumakura Y, Hayashi T, et al
  • Journal Title: Synapse Volume: 65(8) Pages: 751-762
• [Journal Article] Survival of Human Induced Pluripotent Stem Cell. Derived Midbrain Dopaminergic Neurons in the Brain of a Primate Model of Parkinson's Disease (2011)
  • Author(s): Kikuchi T, Morizane A, Doi D, Onoe H, Hayashi T, et al
  • Journal Title: Journal of Parkinson's Disease Volume: 1(4) Pages: 395-412
• [Journal Article] Objective and quantitative evaluation of motor function in a monkey model of Parkinson's disease (2010)
  • Author(s): Saiki H, Hayashi T, Takahashi R, Takahashi J
  • Journal Title: J. Neurosci. Methods Volume: 190(2) Pages: 198-204
• [Journal Article] Establishment of in vivo brain imaging method in conscious mice (2010)
  • Author(s): Mizuma H, Shukuri M, Hayashi T, Watanabe Y, Onoe H
  • Journal Title: J. Nucl. Med Volume: 51(7) Pages: 1068-1075
• [Journal Article] Long-term observation of auto-cell transplantation in non-human primate reveals safety and efficiency of bone marrow stromal cell-derived Schwann cells in peripheral nerve regeneration (2010)
  • Author(s): Wakao S, Hayashi T, Kitada M, et al
  • Journal Title: Exp. Neurol Volume: 223(2) Pages: 537-547
• [Journal Article] Optimization of transmission scan duration for 15O PET study with sequential dual tracer administration using N-index (2010)
  • Author(s): Kudomi N, Watabe H, Hayashi T, et al
  • Journal Title: Ann Nucl Med Volume: 24(5) Pages: 413-420
  • NAID: 10027658962
• [Journal Article] Measurement of density and affinity for dopamine D(2) receptors by a single positron emission tomography scan with multiple injections of[(11) C] raclopride (2010)
  • Author(s): Ikoma Y, Watabe H, Hayashi T, et al
  • Journal Title: J. Cereb. Blood Flow Metab Volume: 30(3) Pages: 663-673
• [Journal Article] Quantification of regional myocardial oxygen metabolism in normal pigs using positron emission tomography with injectable(15) O-O(2) (2010)
  • Author(s): Temma T, Iida H, Hayashi T, et al
  • Journal Title: Eur. J. Nucl. Med. Mol. Imaging Volume: 37(2) Pages: 377-385
• [Journal Article] Development of motion correction technique for cardiac(15) O-water PET study using an optical motion tracking system (2010)
  • Author(s): Koshino K, Watabe H, Hasegawa S, Hayashi T, et al
  • Journal Title: Ann Nucl Med Volume: 24(1) Pages: 1-11
  • NAID: 10026099811
• [Journal Article] Sensitivity of kinetic macro-parameters to changes in dopamine synthesis, storage and metabolism : A simulation study for [(18)F]FDOPA PET by a model with detailed dopamine pathway (2010)
  • Author(s): Matsubara K, et al.
  • Journal Title: Synapse Volume: (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Objective and quantitative evaluation of motor function in a monkey model of Parkinson's disease (2010)
  • Author(s): Saiki H, et al.
  • Journal Title: J Neurosci Methods Volume: 190 Pages: 198-204
  • Peer Reviewed
• [Journal Article] Establishment of in vivo brain imaging method in conscious mice (2010)
  • Author(s): Mizuma H, et al.
  • Journal Title: J Nucl Med Volume: 51 Pages: 1068-1075
  • Peer Reviewed
• [Journal Article] Measurement of density and affinity for dopamine D(2)receptors by a single positron emission tomography scan with multiple injections of [(11)C]raclopride (2010)
  • Author(s): Ikoma Y, et al
  • Journal Title: J Cereb Blood Flow Metab 30 Pages: 663-673
  • Peer Reviewed
• [Journal Article] A physiologic model for recirculation water correction in CMRO2 assessment with 15O2 inhalation PET (2009)
  • Author(s): Kudomi N, Hayashi T, Watabe H, et al
  • Journal Title: J Cereb Blood Flow Metab Volume: 29(2) Pages: 355-64
• [Journal Article] Influence of residual oxygen-15-labeled carbon monoxide radioactivity on cerebral blood flow and oxygen extraction fraction in a dual-tracer autoradiographic method (2009)
  • Author(s): Iwanishi K, Watabe H, Hayashi T, et al
  • Journal Title: Ann Nucl Med Volume: 23(4) Pages: 363-71
  • NAID: 10025136396
• [Journal Article] Evaluation of utility of asymmetric index for count-based oxygen extraction fraction on dual-tracer autoradiographic method for chronic unilateral brain infarction (2009)
  • Author(s): Iwanishi K, Watabe H, Fujisaki H, Hayashi T, et al
  • Journal Title: Ann Nucl Med Volume: 23(6) Pages: 533-9
  • NAID: 10026390230
• [Journal Article] Quantitative evaluation of changes in binding potential with a simplified reference tissue model and multiple injections of[11C] raclopride (2009)
  • Author(s): Ikoma Y, Watabe H, Hayashi T, et al
  • Journal Title: Neuroimage Volume: 47(4) Pages: 1639-48
• [Journal Article] An acute psychosocial stress enhances the neural response to smoking cues (2009)
  • Author(s): Dagher A, Tannenbaum B, Hayashi T, Pruessner JC, McBride D
  • Journal Title: Brain Res Volume: 1293 Pages: 40-8
• [Journal Article] [18F] FDOPA PETデータのPatlak解析により推定された取り込み定数のバイアス評価:[18F] FDOPA代謝産物の影響 (2009)
  • Author(s): 松原佳亮,渡部浩司,林拓也,飯田秀博,湊光太郎
  • Journal Title: 生体医工学 Volume: 48(1) Pages: 66-74
  • NAID: 10031199746
• [Journal Article] Quantification of regional myocardial oxygen metabolism in normal pigs using positron emission tomography with injectable(15)O-O(2) (2009)
  • Author(s): Temma T, et al
  • Journal Title: Eur J Nucl Med Mol Imaging 37 Pages: 377-385
  • Peer Reviewed
• [Journal Article] Development of motion correction technique for cardiac 15O-water PET study using an optical motion trackine system (2009)
  • Author(s): Koshino K, et al.
  • Journal Title: Ann Nucl Med 24 Pages: 1-11
  • Peer Reviewed
• [Journal Article] 骨髄間葉系細胞を用いたパーキンソン病への自己細胞移植の可能性 (2009)
  • Author(s): 林拓也
  • Journal Title: 日本臨床増刊号:パーキンソン病-基礎・臨床研究のアップデート Pages: 429-434
• [Journal Article] 高磁場MRI (2009)
  • Author(s): 林拓也
  • Journal Title: 最新循環器診療マニュアル Pages: 573-580
• [Journal Article] Influence of residual oxygen-15-labeled carbon monoxide radioactivity on cerebral blood flow and oxygen extraction fraction in a dual-tracer autoradiographic method (2009)
  • Author(s): Iwanishi K, et al
  • Journal Title: Ann Nucl Med 23 Pages: 363-371
  • Peer Reviewed
• [Journal Article] Evaluation of utility of asymmetric index for count-based oxygen extraction fraction on dual-tracer autoradiographic method for chronic unilateral brain infarction (2009)
  • Author(s): Iwanishi K, et al
  • Journal Title: Ann Nucl Med 23 Pages: 533-539
  • Peer Reviewed
• [Journal Article] Quantitative evaluation of changes in binding potential with a simplified reference tissue model and multiple injections of [11C]raclopride (2009)
  • Author(s): Ikoma Y, et al
  • Journal Title: Neuroimage 47 Pages: 1639-48
  • Peer Reviewed
• [Journal Article] An acute psychosocial stress enhances the neural response to smoking cues (2009)
  • Author(s): Dagher, et al
  • Journal Title: Brain Res 1293 Pages: 40-48
  • Peer Reviewed
• [Journal Article] Long-term observation of auto-cell transplantation in non-human primate reveals safety and efficiency of bone marrow stromal cell-derived Schwann cells in peripheral nerve regeneration
  • Author(s): Wakao S, et al.
  • Journal Title: Exp Neurol (In press)
  • Peer Reviewed
• [Presentation] Plastic changes in the ventral premotor area after primary motor cortex lesion in macaque monkeys : Possible involvement in functional compensation of manual dexterity (2011)
  • Author(s): Murata Y, Higo, N, Hayashi T, Nishimura Y, Sugiyama Y, Oishi T, Tsukada H, Isa T, Onoe H
  • Organizer: Society for Neuroscience 2011
  • Place of Presentation: Washington, DC
  • Year and Date: 2011-11-13
• [Presentation] Plastic changes in the ventral premotor area after primary motor cortex lesion in macaque monkeys : Possible involvement in functional compensation of manual dexterity (2011)
  • Author(s): Murata Y, Higo N, Hayashi T, et al
  • Organizer: Society for Neuroscience 2011
  • Place of Presentation: Washington
• [Presentation] 依存にかかわる皮質基底核回路-fMRI+TMS (2011)
  • Author(s): 林拓也
  • Organizer: 第13回日本ヒト脳機能マッピング学会・シンポジウム4マッピングからネットワークの解析へ
  • Place of Presentation: 京都
• [Presentation] Dissecting frontal lobe contributions to drug craving with fMRI and TMS (2011)
  • Author(s): Hayashi T, Ko J, Strafella A, Dagher A
  • Organizer: 17th Annual Meeting of the Organization for Human Brain Mapping
  • Place of Presentation: Quebec
• [Presentation] 拡散テンソル画像でみた神経変性動態-緑内障視神経障害モデル動物における観察Kinetics of neurodegeneration revealed by diffusion tensor imaging in animal model of glaucomatous optic neuropathy (2011)
  • Author(s): 林拓也,原英彰,島澤雅光, et al
  • Organizer: 第6回日本分子イメージング学会
  • Place of Presentation: 神戸
• [Presentation] Alternation of Functional Connectivity after Corticospinal Tract Infarction-A Longitudinal Case-control Functional MRI study (2011)
  • Author(s): Takenobu Y, Hayashi T, Moriwaki H, et al
  • Organizer: International Stroke Conference 2011
  • Place of Presentation: Los Angels
• [Presentation] Modeling glaucomatous neurodegeneration using diffusion tensor imaging (2010)
  • Author(s): Hayashi T, Shimazawa M, Inokuchi Y, et al
  • Organizer: World Molecular Imaging Conference 2010
  • Place of Presentation: Kyoto
  • Year and Date: 2010-09-08
• [Presentation] Modeling glaucomatous neurodegeneration using diffusion tensor imaging (2010)
  • Author(s): Hayashi T, et al.
  • Organizer: World Molecular Imaging Conference 2010
  • Place of Presentation: 京都
  • Year and Date: 2010-09-08
• [Presentation] From motivated decision making to drug craving : interaction within prefrontal cortex (2010)
  • Author(s): Hayashi T, Ji Hyun K, Strafella A, Dagher A
  • Organizer: 33th Japan Neuroscience Society
  • Place of Presentation: Kobe
  • Year and Date: 2010-09-04
• [Presentation] From motivated decision making to drug craving : interaction within prefrontal cortex (2010)
  • Author(s): Hayashi T, et al.
  • Organizer: 第33回日本神経科学会
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-04
• [Presentation] Functional and Structural Reorganization After Corticospinal Tract Infarction-A Longitudinal Functional MRI and Diffusion Tensor Image Study- (2010)
  • Author(s): Takenobu, et al.
  • Organizer: International Stroke Conference 2010
  • Place of Presentation: San Antonio
  • Year and Date: 2010-02-24
• [Presentation] The role of perilesional area for functional compensation of manual dexterity after primary motor cortex lesion in macaque monkeys (2010)
  • Author(s): Murata Y, Higo N, Hayashi T, et al
  • Organizer: Society for Neuroscience 2010
  • Place of Presentation: San Diego, USA
• [Presentation] 緑内障視神経障害モデル動物における拡散テンソル画像Diffusion tensor imaging in animal model of glaucomatous optic neuropathy (2010)
  • Author(s): 林拓也,原英彰,嶋澤雅光, et al
  • Organizer: 日本分子イメージング学会
• [Presentation] Functional and Structural Reorganization After Corticospinal Tract Infarction-A Longitudinal Functional MRI and Diffusion Tensor Image Study (2010)
  • Author(s): Takenobu Y, Hayashi T, Moriwaki H, et al
  • Organizer: International Stroke Conference 2010
  • Place of Presentation: San Antonio, TX
• [Presentation] ヒト～動物における脳画像法・脳損傷法を組み合わせた領域間連絡性・因果性の推定 (2009)
  • Author(s): 林拓也
  • Organizer: 第39回日本臨床神経生理学会学術大会
  • Place of Presentation: 北九州国際会議場(北九州)
  • Year and Date: 2009-11-18
• [Presentation] Changes in regional brain activities involved in functional recovery after primary motor cortex lesion : PET study with macaque monkeys (2009)
  • Author(s): 村田弓,肥後範行,西村幸男, et al
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-18
• [Presentation] Dynamic change in Connectivity in Brain Disease of Primates -Plasticity and connectivity (2009)
  • Author(s): 林拓也
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋国際会議場(名古屋)
  • Year and Date: 2009-09-18
• [Presentation] Changes in regional brain activities involved in functional recovery after primary motor cortex lesion : PET study with macaque monkeys (2009)
  • Author(s): 村田弓, 他
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋国際会議場(名古屋)
  • Year and Date: 2009-09-17
• [Presentation] ヒト～動物における脳画像法・脳損傷法を組み合わせた領域間連絡性・因果性の推定 (2009)
  • Author(s): 林拓也
  • Organizer: 第39回日本臨床神経生理学会学術大会
  • Place of Presentation: 北九州
• [Presentation] Dynamic change in Connectivity in Brain Disease of Primates-Plasticity and connectivity (2009)
  • Author(s): Hayashi T
  • Organizer: 第32回日本神経科学大会・シンポジウム「霊長類疾患モデル動物を用いた分子・機能イメージング研究」
  • Place of Presentation: 名古屋
• [Book] 高磁場MRI. In :循環器診療マニュアル2009年 (2009)
  • Author(s): 林拓也
  • Publisher: 中山書店
• [Book] 骨髄間葉系細胞を用いたパーキンソン病への自己細胞移植の可能性. In :日本臨床増刊号:パーキンソン病ー基礎・臨床研究のアップデート (2009)
  • Author(s): 林拓也,出澤真理
  • Publisher: 日本臨床社
• [Remarks] 1.拡散強調画像の歪み・動き補正・テンソル計算プログラム