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Autonomous flowing tube system for chemical solution propelled by its self-energy

Research Project

Project/Area Number 21650041
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Perception information processing/Intelligent robotics
Research InstitutionTokyo Medical and Dental University

Principal Investigator

MITSUBAYASHI Kohji  東京医科歯科大学, 生体材料工学研究所, 教授 (40307236)

Co-Investigator(Kenkyū-buntansha) HIROYUKI Kudo  東京医科歯科大学, 生体材料工学研究所, 講師 (70329118)
MIYAJIMA Kumiko  東京医科歯科大学, 生体材料工学研究所, 技術職員 (10516298)
TAKAHASHI Daishi  東京医科歯科大学, 生体材料工学研究所, 特任助教 (20549943)
SAITO Hirokazu  東京工業高等専門学校, 機械工学科, 准教授 (00205668)
荒川 貴博  東京医科歯科大学, 生体材料工学研究所, 助教 (50409637)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,270,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2009: ¥1,200,000 (Direct Cost: ¥1,200,000)
Keywords化学エネルギー / 酵素 / 反応セル / グルコース / 隔膜 / 減圧 / チューブ / 送液
Research Abstract

Novel chemo-mechanical energy conversion device for glucose as blood sugar was constructed using a glucose oxidase immobilized membrane. And an autonomous flowing system for glucose solution was fabricated by applying the device to a reaction cell with some valves. As the results, the novel energy conversion device indicated a decompression behavior which has a linear relationship with the concentration of glucose. The flowing system streamed with glucose solution(approx. 25μl/min) by its self-energy successfully.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (25 results)

All 2011 2010 2009

All Journal Article (11 results) (of which Peer Reviewed: 5 results) Presentation (12 results) Book (2 results)

  • [Journal Article] Biomedical soft contact-lens sensor for in-situ ocular biomonitoring of tear contents2011

    • Author(s)
      M. X. Chu, D. Takahashi, T. Arakawa, H. Kudo, K. Sano, S. Sawada, Y. Iwasaki, K. Akiyoshi, M. Mochizuki, K. Mitsubayashi
    • Journal Title

      Biomedical Microdevices

      Volume: 13 Pages: 306-611

    • Related Report
      2011 Final Research Report
  • [Journal Article] Soft contact lens biosensor for in situ monitoring of tear glucose as non-invasive blood sugar assessment2011

    • Author(s)
      M. X. Chu, K. Miyajima, D. Takahashi, T. Arakawa, K. Sano, S. Sawada, H. Kudo, Y. Iwasaki, K. Akiyoshi, M. Mochizuki, K. Mitsubayashi
    • Journal Title

      Talanta

      Volume: 83 Pages: 960-965

    • Related Report
      2011 Final Research Report
  • [Journal Article] Biomedical soft contact-lens sensor for in-situ ocular biomonitoring of tear contents2011

    • Author(s)
      M.X.Chu, D.Takahashi, T.Arakawa, H.Kudo, K.Sano, S.Sawada, Y.Iwasaki, K.Akiyoshi, M.Mochizuki, K.Mitsubayashi
    • Journal Title

      Biomedical Microdevices

      Volume: 13 Issue: 4 Pages: 603-611

    • DOI

      10.1007/s10544-011-9530-x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Soft contact lens biosensor for in situ monitoring of tear glucose as non-invasive blood sugar assessment2011

    • Author(s)
      Ming Xing Chu, et.al.
    • Journal Title

      Talanta 83 (2011) 960-965

      Volume: 83 Pages: 960-965

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An autonomous drug-release system based on chemo-mechanical energy conversion"Organic Engine"for feedback control of blood glucose2010

    • Author(s)
      R. Kato, M. Munkhjapgal, D. Takahashi, T. Arakawa, H. Kudo, K. Mitsubayashi
    • Journal Title

      Biosensors and Bioelectronics

      Volume: 26 Pages: 1455-1459

    • Related Report
      2011 Final Research Report
  • [Journal Article] Soft-MEMS glucose sensor with functional polymers2010

    • Author(s)
      S. Iguchi, M. K. Chu, D. Takahashi, T. Arakawa, H. Kudo, K. Mitsubayashi
    • Journal Title

      Journal of Photopolymer Science and Technology

      Volume: 23 Pages: 167-170

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Journal Article] An autonomous drug-release system based on chemo-mechanical energy conversion "Organic Engine" for feedback control of blood glucose2010

    • Author(s)
      Ryodai KATO, et.al.
    • Journal Title

      Biosensors and Bioelectronics

      Volume: 26 Pages: 1455-1459

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tonometric biosensor with a differential pressure sensor for chemo-mechanical measurement of glucose2009

    • Author(s)
      K. Mitsubayashi, T. Ohgoshi, T. Okamoto, Y. Wakabayashi, M. Kozuka, K. Miyajima, H. Saito, H. Kudo
    • Journal Title

      Biosens Bioelectron

      Volume: 24 Pages: 1518-1521

    • Related Report
      2011 Final Research Report
  • [Journal Article] A soft and flexible biosensor using a phospholipid polymer for continuous glucose monitoring2009

    • Author(s)
      M. X. Chu, H. Kudo, T. Shirai, K. Miyajima, H. Ssaito, N. Morimoto, K. Yano, Y. Iwasaki, K. Akiyoshi, K. Mitsubayashi
    • Journal Title

      Biomed Microdevices

      Volume: 11 Pages: 837-842

    • Related Report
      2011 Final Research Report
  • [Journal Article] Tonometric biosensor with a differential pressure sensor for chemo-mechanical measurement of glucose2009

    • Author(s)
      Kohji Mitsubayashi, et.al.
    • Journal Title

      Biosens Bioelectron 24

      Pages: 1518-1521

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A soft and flexible biosensor using a phospholipid polymer for continuous glucose monitoring2009

    • Author(s)
      Ming Xing CHU, et.al.
    • Journal Title

      Biomed Microdevices 11

      Pages: 837-842

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Bio-inspired self-regulation system of glucose level with chemo-mechanical energy conversion bio-membrane2011

    • Author(s)
      Munkhjargal M, Kato R, Miyajima K, Arakawa T, Kudo H, Mitsubayashi K.
    • Organizer
      International Bionic Engineering Conference2011
    • Place of Presentation
      Boston, USA
    • Year and Date
      2011-09-18
    • Related Report
      2011 Final Research Report
  • [Presentation] Bio-inspired self-regulation system of glucose level with chemo-mechanical energy conversion bio-membrane2011

    • Author(s)
      Munkhjargal M, Kato R, Miyajima K, Arakawa T, Kudo H, Mitsubayashi K
    • Organizer
      International Bionic Engineering Conference 2011
    • Place of Presentation
      Boston, USA
    • Year and Date
      2011-09-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] An autonomous drug-release system based on chemo-mechanical energy conversion for blood sugar control2010

    • Author(s)
      M. Munkhjargal, R. Kato, D. Takahashi, T. Arakawa, H. Kudo, K. Mitsubayashia
    • Organizer
      Pacifichem 2010
    • Place of Presentation
      Honolulu, USA
    • Year and Date
      2010-12-15
    • Related Report
      2011 Final Research Report
  • [Presentation] An autonomous drug-release system based on chemo-mechanical energy conversion for blood sugar control2010

    • Author(s)
      Munkhjargal Munkhbayar, et.al.
    • Organizer
      Pacifichem 2010
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Year and Date
      2010-12-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] Bio-energetic self-regulation system of glucose level with chemo-mechanical drug release function2010

    • Author(s)
      R. Kato, D. Takahashi, T. Arakawa, H. Kudo, K. Mitsubayashi
    • Organizer
      20th Anniv. meeting of World Congress on Biosensors
    • Place of Presentation
      Glasgow, UK
    • Year and Date
      2010-05-26
    • Related Report
      2011 Final Research Report
  • [Presentation] Bio-energetic self-regulation system of glucose level with chemo-mechanical drug release function2010

    • Author(s)
      Ryodai Kato, et.al.
    • Organizer
      20th Anniv.meeting of World Congress on Biosensors
    • Place of Presentation
      Glasgow, UK
    • Year and Date
      2010-05-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] Autonomous Biosensors & BioSystem with Organic Engine(Bio-energetic intelligent function using artificial active transportation)2010

    • Author(s)
      K. Mitsubayashi
    • Organizer
      6th Sweden-Japan Workshop on BioNano Technology
    • Place of Presentation
      Mishima, Japan
    • Year and Date
      2010-05-12
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] Intelligent kinetic biosensors with visible motions to target analyte2009

    • Author(s)
      T. Okamoto, D. Takahashi, T. Arakawa, H. Kudo, K. Mitsubayashi
    • Organizer
      First Bio-Sensing Technology Conference
    • Place of Presentation
      Bristol, UK
    • Year and Date
      2009-11-12
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] Bio-transducers for biomedical applications2009

    • Author(s)
      K. Mitsubayashi
    • Organizer
      2009International Conference on Solid State Devices and Materials(SSDM2009)
    • Place of Presentation
      Sendai, Japan
    • Year and Date
      2009-10-07
    • Related Report
      2011 Final Research Report
  • [Presentation] Bio-transducers for biomedical applications2009

    • Author(s)
      Kohji Mitsubayashi
    • Organizer
      2009 International Conference on Solid State Devices and Materials(SSDM 2009)
    • Place of Presentation
      Sendai, Japan
    • Year and Date
      2009-10-07
    • Related Report
      2009 Annual Research Report
  • [Presentation] Kinetic Biosensors with Intelligent Visible Motions for Chemical Analytes2009

    • Author(s)
      Y. Wakabayashi, T. Okamoto, K. Miyajima, D. Takahashi, T. Arakawa, H. Kudo, K. Mitsubayashi
    • Organizer
      Euroanalysis2009
    • Place of Presentation
      Innsbruck, Austria
    • Year and Date
      2009-09-06
    • Related Report
      2011 Final Research Report
  • [Presentation] Kinetic Biosensors with Intelligent Visible Motions for Chemical Analyytes2009

    • Author(s)
      Yoshihiko Wakabayashi, et.al.
    • Organizer
      Euroanalysis 2009
    • Place of Presentation
      Innsbruck, Austria
    • Year and Date
      2009-09-06
    • Related Report
      2009 Annual Research Report
  • [Book] 第17章次世代医療・ヘルスケアのためのウエアラブルセンサ,ヘルスケアとバイオ医療のための先端デバイス機器2009

    • Author(s)
      工藤寛之、三林浩二
    • Publisher
      CMC出版
    • Related Report
      2011 Final Research Report
  • [Book] 「ヘルスケアとバイオ医療のための先端デバイス機器(監修:三林浩二)2009

    • Author(s)
      工藤寛之, 他
    • Total Pages
      10
    • Publisher
      【第4編 健康医療センサ・診断機器】第17章 次世代医療・ヘルスケアのためのウエアラブルセンサ
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2017-10-16  

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