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Development of transparent electrode with curved surface for simultaneous detection of the electrocorticogram from inside of the optical recording area and/or for giving electro-stimulations to the area

Research Project

Project/Area Number 21650095
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Neurophysiology and muscle physiology
Research InstitutionShimane University

Principal Investigator

HIROTA Akihiko  島根大学, 医学部, 教授 (50156717)

Co-Investigator(Kenkyū-buntansha) ITO Shin-ichi  島根大学, 医学部, 准教授 (10145295)
ENOMOTO Koh-ichi  島根大学, 医学部, 助教 (70112125)
HAMA Noriyuki  島根大学, 医学部, 助教 (60422010)
Co-Investigator(Renkei-kenkyūsha) FUJITA Yasuhisa  島根大学, 総合理工学部, 教授 (10314618)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,240,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2009: ¥1,100,000 (Direct Cost: ¥1,100,000)
Keywords透明電極 / 膜電位の光学測定 / ガリウム添加酸化亜鉛 / 曲面形状 / ラット / 感覚運動野 / 単一掃引記録 / 自発性活動 / 紫外線硬化型レジスト / 皮質脳波
Research Abstract

We have developed a transparent electrode for detecting electrocorticogram simultaneously from optical recording area. We have designed shape of the contact face of the electrode base to a comparable curvature to fit the surface of the adult rat cerebral cortex, and finally we used a glass plano-concave lens for an electrode base. Ga doped ZnO film, a transparent conductor, was deposited on the curved surface and covered with SiO_2 film except some dots. As a result, some halls on the curved surface were remained as the only exposed conductor, and they eventually served as independent electrodes. Using this electrode, we succeeded in decreasing the artifact originated heartbeat pulse on the optical signals.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (20 results)

All 2012 2011 2010 2009

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (18 results)

  • [Journal Article] An improved multiple-site optical membrane potential-recording system to obtain high-quality single sweep signals in intact rat cerebral cortex2010

    • Author(s)
      Noriyuki Hama, Shin-ichi Ito, Akihiko Hirota
    • Journal Title

      Journal of Neuroscience Methods

      Volume: Vol.194 Pages: 73-80

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] An improved multiple-site optical membrane potential-recording system to obtain high-quality single sweep signals in intact rat cerebral cortex.2010

    • Author(s)
      N.Hama, S.Ito, A.Hirota
    • Journal Title

      Journal of Neuroscience Methods

      Volume: 194 Pages: 73-80

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Effect of the stimulus intensity on the spatiotemporal patterns of evoked activity in the rat sensorimotor cortex analyzed using optical recording system2012

    • Author(s)
      Noriyuki Hama, Shinichi Ito, Akihiko Hirota
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      松本文化会館(長野県松本市)
    • Year and Date
      2012-03-30
    • Related Report
      2011 Final Research Report
  • [Presentation] Effect of the stimulus intensity on the spatiotemporal patterns of evoked activity in the rat sensorimotor cortex analyzed using optical recording system2012

    • Author(s)
      N.Hama, S.Ito, A.Hirota
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      松本文化会館(長野県)
    • Year and Date
      2012-03-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] 光学的膜電位測定法を用いて解析したラット大脳皮質運動感覚野における感覚刺激応答の時空間パターンと刺激強度の関係2011

    • Author(s)
      濱徳行, 伊藤眞一, 廣田秋彦
    • Organizer
      第63回日本生理学会中国四国地方会
    • Place of Presentation
      広島大学霞キャンパス広仁会館(広島県広島市)
    • Year and Date
      2011-10-22
    • Related Report
      2011 Final Research Report
  • [Presentation] 光学的膜電位測定法を用いて解析したラット大脳皮質運動感覚野における感覚刺激応答の時空間パターンと刺激強度の関係2011

    • Author(s)
      濱徳行、伊藤眞一、廣田秋彦
    • Organizer
      第63回日本生理学会中国四国地方会
    • Place of Presentation
      広島大学霞キャンパス広仁会館(広島県)
    • Year and Date
      2011-10-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] 光学的膜電位測定法を用いたラット運動感覚野における自発興奮伝導パターンの解析2011

    • Author(s)
      濱徳行, 伊藤眞一, 廣田秋彦
    • Organizer
      日本動物学会第82回旭川大会
    • Place of Presentation
      旭川市大クリスタルホール(北海道旭川市)
    • Year and Date
      2011-09-21
    • Related Report
      2011 Final Research Report
  • [Presentation] 光学的膜電位測定法を用いたラット運動感覚野における自発興奮伝導パターンの解析2011

    • Author(s)
      濱徳行、伊藤眞一、廣田秋彦
    • Organizer
      日本動物学会第82回旭川大会
    • Place of Presentation
      旭川市大雪クリスタルホール(北海道)
    • Year and Date
      2011-09-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] Relationship between the stimulus intensity and the spatio-temporal patterns of the evoked activity in the rat sensorimotor cortex using improved optical recording system2011

    • Author(s)
      Noriyuki Hama, Shin-ichi Ito, Akihiko Hirota
    • Organizer
      The 34th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2011-09-16
    • Related Report
      2011 Final Research Report
  • [Presentation] Comparison of propagating patterns of spontaneous and evoked activity in the rat sensorimotor cortex detected by a multiple-site optical recording system2011

    • Author(s)
      Noriyuki Hama, Shin-ichi Ito and Akihiko Hirota
    • Organizer
      第88回日本生理学会大会(東北関東大震災の為会場開催中止)
    • Place of Presentation
      Journal of Physiological Sciences
    • Year and Date
      2011-03-28
    • Related Report
      2011 Final Research Report
  • [Presentation] Comparison of propagating patterns of spontaneous and evoked activity in the rat sensorimotor cortex detected by a multiple-site optical recording system2011

    • Author(s)
      N.Hama, S.Ito, A.Hirota
    • Organizer
      第88回日本生理学会大会(東北関東大震災の為会場開催中止)
    • Place of Presentation
      Journal of Physiological Sciences Vol.61 Suppl.1 S146(誌上開催)
    • Year and Date
      2011-03-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] Relationship between the stimulus intensity and the spatio-temporal patterns of the evoked activity in the rat sensorimotor cortex using improved optical recording system2011

    • Author(s)
      N.Hama, S.Ito, A.Hirota
    • Organizer
      The 34th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 光学的膜電位測定法を用いたラット大脳皮質運動感覚野における神経活動の長時間記録2010

    • Author(s)
      濱徳行, 伊藤眞一, 廣田秋彦
    • Organizer
      第62回日本生理学会中国四国地方会
    • Place of Presentation
      島根大学出雲キャンパス(島根県出雲市)
    • Year and Date
      2010-11-20
    • Related Report
      2011 Final Research Report
  • [Presentation] 光学的膜電位測定法を用いたラット大脳皮質運動感覚野における神経活動の長時間記録2010

    • Author(s)
      濱徳行, 伊藤眞一, 廣田秋彦
    • Organizer
      第62回日本生理学会中国四国地方会
    • Place of Presentation
      島根大学出雲キャンパス(島根県)
    • Year and Date
      2010-11-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] Diversity in the spatio-temporal pattern of spontaneous neural activities in the rat sensorimotor cortex detected with the multiple-site optical recording system with high signal-to-noise ratio2010

    • Author(s)
      Noriyuki Hama, Shin-ichi Ito, Akihiko Hirota
    • Organizer
      第33回日本神経科学大会
    • Place of Presentation
      神戸コンベンションセンター(兵庫県神戸市)
    • Year and Date
      2010-09-04
    • Related Report
      2011 Final Research Report
  • [Presentation] Diversity in the spatio-temporal pattern of spontaneous neural activities in the rat sensorimotor cortex detected with the multiple-site optical recording system with high signal-to-noise ratio2010

    • Author(s)
      N.Hama, S.Ito, A.Hirota
    • Organizer
      第33回日本神経科学大会
    • Place of Presentation
      神戸コンベンションセンター(兵庫県)
    • Year and Date
      2010-09-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] Single sweep analysis on the long-duration continuous multiple-site recording of neural activity obtained optically from in vivo rat somatosensory cortex stained with a voltage-sensitive dye2010

    • Author(s)
      Noriyuki Hama, Shin-ichi Ito, Akihiko Hirota
    • Organizer
      第87回日本生理学会大会
    • Place of Presentation
      盛岡市民文化ホール(岩手県盛岡市)
    • Year and Date
      2010-05-21
    • Related Report
      2011 Final Research Report
  • [Presentation] Single sweep analysis on the long-duration continuous multiple-site recording of neural activity obtained optically from in vivo rat somatosensory cortex stained with a voltage-sensitive dye2010

    • Author(s)
      N.Hama, S.Ito, A.Hirota
    • Organizer
      第87回日本生理学会大会
    • Place of Presentation
      盛岡市民文化ホール(岩手県)
    • Year and Date
      2010-05-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] 光学的膜電位長時間連続測定法のin vivoラット運動感覚野への適用と単一掃引記録した神経活動の定量解析2009

    • Author(s)
      濱徳行, 伊藤眞一, 廣田秋彦
    • Organizer
      第61回日本生理学会中国四国地方会
    • Place of Presentation
      山口大学医学部小串キャンパス内霜仁会館(山口県宇部市)
    • Year and Date
      2009-11-21
    • Related Report
      2011 Final Research Report
  • [Presentation] Analysis of spontaneous activity in the rat sensorimotor cortex recorded optically with voltage-sensitive dye2009

    • Author(s)
      Noriyuki Hama, Shin-ichi Ito, Akihiko Hirota
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2009-09-18
    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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