Molecular genetic analysis of hybrid vigor and inbreeding depression utilizing recombinant inbred mouse strains
| Project/Area Number |
21650097
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Laboratory animal science
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| Research Institution | Shinshu University |
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Principal Investigator |
MORI Masayuki 信州大学, 医学系研究科, 准教授 (60273190)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,330,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2009: ¥800,000 (Direct Cost: ¥800,000)
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| Keywords | リコンビナント近交系 / 雑種強勢 / 近交退化 / マウス / 遺伝解析 |
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| Research Abstract |
It was revealed that the hybrid mice from genetically distant SM/J and A/J mouse strains showed superiority to the parental strains in growth and breeding performances. It was suggested that the recombinant inbred mouse strains derived from SM/J and A/J would be a valuable tool for elucidation of the mechanisms of hybrid vigor and inbreeding depression.
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Report
(4 results)
Research Products
(17 results)
