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Development of a Variable-Energy, Variable-Intensity, On/Off-Switchable Gamma-Ray Needle Source for Brachytherapy

Research Project

Project/Area Number 21650126
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Medical systems
Research InstitutionTokyo Institute of Technology

Principal Investigator

OGURI Yoshiyuki  東京工業大学, 原子炉工学研究所, 教授 (90160829)

Co-Investigator(Kenkyū-buntansha) HASEGAWA Jun  東京工業大学, 大学院・総合理工学研究科, 准教授 (90302984)
Co-Investigator(Renkei-kenkyūsha) OGAWA Masao  駒澤大学, 医療健康科学部, 教授 (60016863)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,400,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2009: ¥900,000 (Direct Cost: ¥900,000)
Keywords小線源治療 / 陽子線 / 注射針 / 荷電粒子励起X線 / 静電加速器 / 吸収線量 / 陽子ビーム / 特性X線 / 半導体X線検出器 / イオンビーム / ガンマ線 / クーロン励起 / 深部ガン治療 / ガラスキャピラリー / 加速器 / 小角散乱
Research Abstract

We investigated the feasibility of a new cancer therapy, in which a syringe needle is inserted into the tumor deep inside the patient's body and a proton beam is transported through the needle to a heavy-metal target at the end in order to produce gamma-rays. Since preliminary measurements showed that the gamma-ray intensity was not enough, we used characteristic X-rays instead. After precise alignment, the beam transmission has reached 80% of the value expected from the needle bore size. Ag KX-rays were produced by attaching a Ag target at the end of the needle. Only Ag KX-rays were successfully extracted, since other low-energy X-rays were attenuated by the needle wall.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (10 results)

All 2011 2010 2009

All Journal Article (5 results) (of which Peer Reviewed: 1 results) Presentation (5 results)

  • [Journal Article] Proton-Beam Transport Experiments through a Syringe Needle for the Development of a Cancer Therapy Using Proton-Induced X-rays2011

    • Author(s)
      Y. Oguri and J. Hasegawa
    • Journal Title

      Bull. Res. Lab. Nucl. Reactor.

      Volume: Vol.35 Pages: 19-20

    • Related Report
      2011 Final Research Report
  • [Journal Article] Proton-Beam-Transport Experiments through a Syringe Needle for the Development of a Cancer Therapy Using Proton-Induced X-rays2011

    • Author(s)
      Y.Oguri, J.Hasegawa
    • Journal Title

      Bulletin of the Research Laboratory for Nuclear Reactors

      Volume: 35 Pages: 19-20

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Development of a Micro-PIXE System Using Tapered Glass Capillary Optics2011

    • Author(s)
      J.Hasegawa, S.Jaiyen, Y.Oguri
    • Journal Title

      Nuclear Instruments and Methods B

      Volume: (印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 注射針を用いた深部ガン治療用陽子線励起特性X線源からのX線エネルギースペクトル測定2010

    • Author(s)
      小栗慶之, 長谷川純
    • Journal Title

      複合照射実験装置研究報告2010

      Pages: 68-75

    • Related Report
      2011 Final Research Report
  • [Journal Article] Monte-Carlo Simulation of MeV Ion Focusing by Tapered Capllary Optics2009

    • Author(s)
      J.Hasegawa, Y.Oguri
    • Journal Title

      Bull.Res.Lab.Nucl.Reactor. 33

      Pages: 17-17

    • Related Report
      2009 Annual Research Report
  • [Presentation] 注射針を用いた深部ガン治療用陽子線励起特性X線源の開発2011

    • Author(s)
      小栗慶之, 長谷川純
    • Organizer
      日本原子力学会2011年秋の大会
    • Place of Presentation
      北九州国際会議場
    • Year and Date
      2011-09-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] 注射針を用いた深部ガン治療用陽子線励起特性X線源の開発2011

    • Author(s)
      小栗慶之,長谷川純
    • Organizer
      日本原子力学会2011年秋の大会予稿集
    • Place of Presentation
      北九州国際会議場他
    • Related Report
      2011 Final Research Report
  • [Presentation] テーパーキャピラリーによるイオン集束とビーム品質の評価2010

    • Author(s)
      長谷川純, S.Jaiyen, 小栗慶之
    • Organizer
      日本物理学会2010年秋季大会
    • Place of Presentation
      大阪府立大学
    • Year and Date
      2010-09-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] Monte-Carlo Simulation of Ion Beam Focusing Using Glancing-Angle Scattering2010

    • Author(s)
      J.Hasegawa, Y.Oguri, S.Jaiyen
    • Organizer
      The 18th International Symposium on Heavy Ion Inertial Fusion
    • Place of Presentation
      Darmstadt, Germany
    • Year and Date
      2010-08-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] ガラスキャピラリーを用いたマイクロPIXE装置の開発2009

    • Author(s)
      長谷川純, 福田一志, 小栗慶之
    • Organizer
      第22回タンデム加速器びその周辺技術の研究会
    • Place of Presentation
      筑波大学 大学会館ホール
    • Year and Date
      2009-07-17
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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