| Project/Area Number |
21650143
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
ABO Masahiro 東京慈恵会医科大学, 医学部, 教授 (00266587)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAUCHI Hideki 東京慈恵会医科大学, 医学部, 講師 (60220224)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,280,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2009: ¥1,900,000 (Direct Cost: ¥1,900,000)
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| Keywords | 脳卒中 / ES細胞 / アストロサイト / 機能回復 / 神経幹細胞移植 / 脂肪組織由来間葉系幹細 / 回復 / モデルラット / 脂肪組織由来間葉系幹細胞 |
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| Research Abstract |
We selected the rat model of a brain lesion induced by photochemically initiated thrombosis(PIT) through platelet aggregation. The technique involved in this model is simple enough to design the brain lesion as focal and uniform, and the hemiparesis of the hindlimb, induced by injury to the unilateral motor cortex, recovers completely by the 10th day with few individual differences after operation. The purpose of this study was to examine whether using the stem cell transplantation or the mesenchymal stem cell transplantation promotes motor recovery after brain damage in this PIT model. After recovery of left hindlimb function caused by a right sensorimotor cortex lesion, a lesion was induced photochemically in the left sensorimotor cortex as a second PIT and the beam-walking score was recorded for right hindlimb function. As a result, these two methods were not able to promote motor recovery after brain damage in this PIT model.
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