| Budget Amount *help |
¥3,530,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2009: ¥1,100,000 (Direct Cost: ¥1,100,000)
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| Research Abstract |
Among the drugs for angina pectoris and hyperpiesia, sodium nitroprusside, isosorbide dinitrate, nitroglycerin, nicorandil, nipradilol were selected and examined for the presence of protective activities against X-rays-induced injury and toxicities using normal human fibroblasts, AG1522cells. All drugs possessed protective activities against radiation and indicated non-toxicities up to 3μM.
Furthermore, 5drugs were examined for the presence of protective activities against X-rays, mixed radiation(γ-rays and neutron) or neutron-induced injury and toxicities using normal mice(jcl : ICR, 8weeks old, male). All drugs were non-toxicities. However, Sodium nitroprusside only possessed protective activities against the injury induced by X-rays and it is due to promoting of restoration of hematopoietic and immune functions. Sodium nitroprusside was effective in the injury induced by mixed radiation, but not by neutrons alone.
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