Elucidation of mechanisms for protective effects of NO-generating agents against radiation
| Project/Area Number |
21651019
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | University of Fukui |
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Principal Investigator |
MATSUMOTO Hideki 福井大学, 高エネルギー医学研究センター, 准教授 (40142377)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,530,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2009: ¥1,100,000 (Direct Cost: ¥1,100,000)
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| Keywords | 防護 / 一酸化窒素 / 放射線防護剤 / 狭心症治療薬 / X線 / 中性子線 / 造血系細胞 / 免疫系細胞 / 放射線障害 / 放射線防護 / ヒト正常線維芽細胞 / 正常マウス(jcl:ICR) |
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| Research Abstract |
Among the drugs for angina pectoris and hyperpiesia, sodium nitroprusside, isosorbide dinitrate, nitroglycerin, nicorandil, nipradilol were selected and examined for the presence of protective activities against X-rays-induced injury and toxicities using normal human fibroblasts, AG1522cells. All drugs possessed protective activities against radiation and indicated non-toxicities up to 3μM.
Furthermore, 5drugs were examined for the presence of protective activities against X-rays, mixed radiation(γ-rays and neutron) or neutron-induced injury and toxicities using normal mice(jcl : ICR, 8weeks old, male). All drugs were non-toxicities. However, Sodium nitroprusside only possessed protective activities against the injury induced by X-rays and it is due to promoting of restoration of hematopoietic and immune functions. Sodium nitroprusside was effective in the injury induced by mixed radiation, but not by neutrons alone.
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Report
(4 results)
Research Products
(58 results)
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[Journal Article] Molecular Chaperone Inducers Facilitate the Functional Restoration of Temperature-sensitive Mutant p53 Protein2010
Author(s)
Kawashima, D., Soga, M., Takeuchi, R., Matsumoto, H., Ohtsuka, K.
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Journal Title
Thermal Medicine
Volume: 26
Issue: 1
Pages: 1-17
DOI
NAID
ISSN
1882-2576, 1882-3750
Related Report
Peer Reviewed
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[Journal Article] Suppression of histone deacetylase 3(HDAC3) enhances apoptosis induced by paclitaxel in human maxillary cancer cells in vitro and in vivo2010
Author(s)
Narita, N., Fujieda, S., Kimura, Y., Ito, Y., Imoto, Y., Ogi, K., Takahashi, N., Tanaka, T., Tsuzuki, H., Yamada, T., Matsumoto, H.
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Journal Title
Biochem. Biophys. Res. Commun.
Volume: 396
Issue: 2
Pages: 310-316
DOI
Related Report
Peer Reviewed
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[Journal Article] Suppression of histone deacetylase 3 (HDAC3) enhances apoptosis induced by paclitaxel in human maxillary cancer cells in vitro and in vivo.2010
Author(s)
Narita, N.Fujieda, S.Kimura, Y.Ito, Y.lmoto, Y.Ogi, K.,Takahashi, N.Tanaka, T,Tsuzuki, H.Yamada, T.Matsumoto. H.
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Journal Title
Biochem. Biophys. Res. Commun.
Volume: 396
Pages: 310-316
Related Report
Peer Reviewed
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[Journal Article] Suppression of histone deacetylase 3 (HDAC3) enhances apoptosis induced by paclitaxel in human maxillary cancer cells in vitro and in vivo2010
Author(s)
Narita N, Fujieda S, Kimura Y, Ito Y, Imoto Y, Ogi K, Takahashi N, Tanaka T, Tsuzuki H, Yamada T, Matsumoto H
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Journal Title
Biochem.Biophys.Res.Commun. (in press)
Related Report
Peer Reviewed
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[Presentation] 腸管組織の幹細胞ターンオーバー2011
Author(s)
大塚健介,浜田信行,馬替純二,松本英樹,塚本徹哉,星裕子,野村崇冶,冨田雅典,前田宗利,吉田和生,丹羽太貴,岩崎利泰
Organizer
日本放射線影響学会第54回大会
Place of Presentation
神戸市
Year and Date
2011-11-18
Related Report
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