| Project/Area Number |
21651024
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Ehime University |
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Principal Investigator |
TANABE Shinsuke 愛媛大学, 沿岸環境科学研究センター, 教授 (60116952)
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| Co-Investigator(Renkei-kenkyūsha) |
NOMIYAMA Kei 愛媛大学, 沿岸環境科学研究センター, 助教 (30512686)
TAKASUGA Takumi 愛媛大学, 沿岸環境科学研究センター, 客員教授 (10451379)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,370,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Keywords | 環境分析 / 有害化学物質 / PCBs / 代謝活性化 / 環境汚染 / OH-PCBs / 低塩素化水酸化PCBs / 分析法 / 脳移行 / スナメリ / 野生生物 / 水酸化PCBs代謝物 |
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| Research Abstract |
The present study investigated the accumulation features of lower-chlorinated OH-PCBs in the blood and brain of cetaceans and transitional state of these OH-PCBs into the brain was clarified. Optimization of the extraction and clean-up method was developed for the analyses of lower-chlorinated OH-PCBs in the blood and brain of cetaceans. OH-PCBs tend to accumulate at higher levels in brain than in blood, yet no statistical significance was observed. Congener profile of OH-PCBs in brain was different from that in blood ; penta-chlorinated congeners were dominant in the brain. Thus, specific transfer and accumulation of penta-chlorinated congeners in brain was suspected.
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