Pilot study of analytical methods for the lower-chlorinated hydroxylated PCBs in the blood and brain of wildlife

• Project/Area Number: 21651024
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Risk sciences of radiation/Chemicals
• Research Institution: Ehime University
• Principal Investigator: TANABE Shinsuke 愛媛大学, 沿岸環境科学研究センター, 教授 (60116952)
• Co-Investigator(Renkei-kenkyūsha): NOMIYAMA Kei 愛媛大学, 沿岸環境科学研究センター, 助教 (30512686) ; TAKASUGA Takumi 愛媛大学, 沿岸環境科学研究センター, 客員教授 (10451379)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,370,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥900,000 (Direct Cost: ¥900,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,300,000)
• Keywords: 環境分析 / 有害化学物質 / PCBs / 代謝活性化 / 環境汚染 / OH-PCBs / 低塩素化水酸化PCBs / 分析法 / 脳移行 / スナメリ / 野生生物 / 水酸化PCBs代謝物

Research Abstract

The present study investigated the accumulation features of lower-chlorinated OH-PCBs in the blood and brain of cetaceans and transitional state of these OH-PCBs into the brain was clarified. Optimization of the extraction and clean-up method was developed for the analyses of lower-chlorinated OH-PCBs in the blood and brain of cetaceans. OH-PCBs tend to accumulate at higher levels in brain than in blood, yet no statistical significance was observed. Congener profile of OH-PCBs in brain was different from that in blood ; penta-chlorinated congeners were dominant in the brain. Thus, specific transfer and accumulation of penta-chlorinated congeners in brain was suspected.

Research Products

• [Journal Article] Different Profiles of Anthropogenic and Naturally Produced Organohalogen Compounds in Serum from Residents Living near a Coastal Area and E-waste Recycling Workers in India (2012)
  • Author(s): Eguchi A., Nomiyama K., Devanathan G., Subramanian A., Bulbule K. A., Parthasarathy P., Takahashi S., Tanabe S.
  • Journal Title: Environment International Volume: (in press)
  • Peer Reviewed
• [Journal Article] Accumulation of halogenated phenolic compounds in small toothed whales (2012)
  • Author(s): Ochiai, M.
  • Journal Title: Interdisciplinary Studies on Environmental Chemistry Volume: 6 Pages: 187-192
  • Peer Reviewed
• [Journal Article] Organohalogen compounds and their metabolites in the blood of Japanese amberjack(Seriola quinqueradiata) and scalloped hammerhead shark (2011)
  • Author(s): Nomiyama K., Uchiyama Y., Horiuchi S., Eguchi A., Mizukawa H., Horai Hirata S., Shinohara R., Tanabe S.
  • Journal Title: Chemosphere Volume: 85 Pages: 315-321
• [Journal Article] Anthropogenic and naturally occurring polybrominated phenolic compounds in the blood of cetaceans stranded along Japanese coastal waters (2011)
  • Author(s): Nomiyama K., Eguchi A., Mizukawa H., Ochiai M., Murata S., Someya M., Isobe T., Yamada T. K., Tanabe S.
  • Journal Title: Environmental Pollution Volume: 159 Pages: 3364-3373
  • Peer Reviewed
• [Journal Article] Accumulation of Anthropogenic and Natural Origin Organohalogen Compounds in Three Porpoise Species (2011)
  • Author(s): Ochiai, M.
  • Journal Title: Organohalogen Compounds Volume: 73 Pages: 1709-1712
  • Peer Reviewed
• [Journal Article] Polychlorinated biphenyls and their hydroxylated metabolites(OH-PCBs) in the blood of toothed and baleen whales stranded along Japanese coastal waters (2010)
  • Author(s): Nomiyama K., Murata S., Kunisue T., Yamada T. K., Mizukawa H., Takahashi S., Tanabe S.
  • Journal Title: Environmental Science & Technology Volume: 44 Pages: 3732-3738
  • Peer Reviewed
• [Journal Article] Polychlorinated biphenyls and their metabolites (OH-PCBs) in the blood of toothed and baleen whales stranded along Japanese coastal waters (2010)
  • Author(s): Nomiyama, K.
  • Journal Title: Environmental Science and Technology Volume: 44 Pages: 3732-3738
  • Peer Reviewed
• [Journal Article] Accumulation features of PCBs and hydroxylated metabolites in the blood of terrestrial mammals (2010)
  • Author(s): Mizukawa, H.
  • Journal Title: Organohalogen Compounds Volume: 72 Pages: 944-947
  • Peer Reviewed
• [Journal Article] Polychorinated biphenyls (PCBs) and hydroxylated PCBs (OH-PCBs) in three porpoise species : accumulation features and metabolic capacity (2010)
  • Author(s): Ochiai, M.
  • Journal Title: Organohalogen Compounds Volume: 72 Pages: 1027-1030
  • Peer Reviewed
• [Journal Article] Hydroxylated polychlorinated biphenyls(OH-PCBs)in the blood of mammals and birds from Japan : lower chlorinated OH-PCBs and profiles (2009)
  • Author(s): Kunisue T.
  • Journal Title: Chemosphere 74 Pages: 950-961
  • Peer Reviewed
• [Journal Article] Comprehensive study on hydroxylated polychlorinated biphenyls in the blood of cetaceans, including toothed whales and baleen whales stranded at the Japanese coast (2009)
  • Author(s): Nomiyama, K.
  • Journal Title: Organohalogen Compounds 71 Pages: 53-58
  • Peer Reviewed
• [Journal Article] Accumulation features of hydroxylated-PCBs(OH-PCBs)in the blood of pigs collected from dumping site for municipal wastes in India (2009)
  • Author(s): Mizukawa, H.
  • Journal Title: Organohalogen Compounds 71 Pages: 1860-1864
  • Peer Reviewed
• [Presentation] Accumulation of anthropogenic and natural origin organohalogen compouds in three porpoise species (2011)
  • Author(s): Ochiai, M.
  • Organizer: Dioxin 2011
  • Place of Presentation: Brussels, Belgium
  • Year and Date: 2011-08-25
• [Presentation] Accumulation of halogenated phenolic compounds in small toothed whales (2011)
  • Author(s): Ochiai, M.
  • Organizer: The 6th Global COE International Symposium
  • Place of Presentation: 松山
  • Year and Date: 2011-08-05
• [Presentation] ネズミイルカ科の小型鯨類に残留する人為起源および天然起源ハロゲン化フェノール類の蓄積特性 (2011)
  • Author(s): 落合真理
  • Organizer: 第20回環境化学討論会
  • Place of Presentation: 熊本
  • Year and Date: 2011-07-18
• [Presentation] Organohalogen metabolites in marine mammals: Differences in accumulation of natural and anthropogenic hydroxylated metabolites (2011)
  • Author(s): Ochiai, M.
  • Organizer: The 4th Joint Forum of Environmental Sciences
  • Place of Presentation: 松山
  • Year and Date: 2011-06-20
• [Presentation] Accumulation of halogenated phenolic compounds in small toothed whales (2011)
  • Author(s): Ochiai, M., Nomiyama, K., Isobe, T., Yamada, T. K., Tajima, Y., Matsuishi, T., Amano, M. and Tanabe, S.
  • Organizer: The 6^<th> Global COE International Symposium on Advanced Studies by Young Scientists on Environmental Pollution and Ecotoxicology(Abstract Book)
  • Place of Presentation: Matsuyama, Japan
• [Presentation] Accumulation of anthropogenic and natural origin organohalogen compounds in three porpoise species (2011)
  • Author(s): Ochiai, M., Nomiyama, K., Isobe, T., Yamada, T. K., Tajima, Y., Matsuishi, T., Amano, M. and Tanabe, S.
  • Organizer: 31^<st> International Symposium on Halogenated Persistent Organic Pollutants(DIOXIN 2011)(Abstract Book)
  • Place of Presentation: Brussels, Belgium
• [Presentation] ネズミイルカ科の小型鯨類に残留する人為起源および天然起源ハロゲン化フェノール類の蓄積特性 (2011)
  • Author(s): 落合真理・野見山桂・磯部友彦・山田格・田島木綿子・松石隆・天野雅男・田辺信介
  • Organizer: 第20回環境化学討論会(講演要旨集)
  • Place of Presentation: 熊本市
• [Presentation] Hydroxylated polybrominated diphenyl ethers (OH-PBDEs) in the blood of toothed and baleen whales stranded at Japanese coastal waters (2010)
  • Author(s): Nomiyama, K.
  • Organizer: 30^<th> International Symposium on Halogenated Persistent Organic Pollutants (DIOXIN 2010)
  • Place of Presentation: San Antonio, Texas, USA
  • Year and Date: 2010-09-13
• [Presentation] Accumulation features of PCBs and hydroxylated metabolites in the blood of terrestrial mammals (2010)
  • Author(s): Mizukawa, H.
  • Organizer: 30^<th> International Symposium on Halogenated Persistent Organic Pollutants (DIOXIN 2010)
  • Place of Presentation: San Antonio, Texas, USA
  • Year and Date: 2010-09-13
• [Presentation] Accumulation features of PCBs and hydroxylated metabolites in the blood of terrestrial mammals (2010)
  • Author(s): Mizukawa, H.
  • Organizer: 第19回環境化学討論会
  • Place of Presentation: 春日井市
  • Year and Date: 2010-06-23
• [Presentation] Comprehensive study on hydroxylated polychlorinated biphenyls in the blood of cetaceans, including toothed whales and baleen whales stranded at the Japanese coast (2009)
  • Author(s): 野見山桂
  • Organizer: DIOXIN 2009
  • Place of Presentation: Beijing, China, Crowne Plaza Park View Wuzhou
  • Year and Date: 2009-08-24
• [Presentation] 本沿岸に座礁したハクジラ類およびヒゲクジラ類の血中水酸化PCBs (2009)
  • Author(s): 野見山桂
  • Organizer: 第18回環境化学討論会
  • Place of Presentation: 茨城県つくば市つくば国際会議場
  • Year and Date: 2009-06-11
• [Book] Interdisciplinary Studies on Environmental Chemistry, Vol.6 (2012)
  • Author(s): Mizukawa, H., Nomiyama, K., Nakatsu, S., Yachimori, S., Hayashi, T., Tashiro, Y., Yamamoto, M. and Tanabe, S.
  • Publisher: TERRAPUB, Tokyo, Japan(Kawaguchi, M., Misaki, K., Sato, H., Yokokawa, T., Itai, T., Tue, N. M., Ono, J. and Tanabe, S.(Eds))
• [Book] Interdisciplinary Studies on Environmental Chemistry, Vol.6 (2012)
  • Author(s): Ochiai, M., Nomiyama, K., Isobe, T., Yamada, T. K., Tajima, Y., Matsuishi, T., Amano, M. and Tanabe, S.
  • Publisher: TERRAPUB, Tokyo, Japan(Kawaguchi, M., Misaki, K., Sato, H., Yokokawa, T., Itai, T., Tue, N. M., Ono, J. and Tanabe, S.(Eds))
• [Book] Interdisciplinary Studies on Environmental Chemistry, Vol.4 (2010)
  • Author(s): Nomiyama, K., Murata, S., Kunisue, T., Yamada, T. K., Mizukawa, H., Takahashi, S. and Tanabe, S.
  • Publisher: TERRAPUB, Tokyo, Japan(Isobe, T., Nomiyama, K., Subramanian and Tanabe, S.(Eds))
• [Book] Interdisciplinary Studies on Environmental Chemistly, Vol.4, Environmental Specimen Bank : Exploring Possibility of Setting-up ESBs in Developing Countries (2010)
  • Author(s): Isobe, T.
  • Total Pages: 222
  • Publisher: TERRAPUB, Tokyo, Japan
• [Book] Hydroxylated polychlorinated biphenyls in the blood of cetaceans stranded along the Japanese coast (2009)
  • Author(s): Murata, S.
  • Total Pages: 11
  • Publisher: TERRAPUB, Tokyo, Japan
• [Remarks]
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