| Project/Area Number |
21651025
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology |
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Principal Investigator |
SHINKAI Tadashi 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (10154387)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2009: ¥2,000,000 (Direct Cost: ¥2,000,000)
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| Keywords | 老化 / ビスフェノールA / 内分泌かく乱物質 / ラット / 運動 |
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| Research Abstract |
The bisphenol A represents a family of ubiquitous environmental pollutants and are well known as environmental endocrine disruptors. It changes multiple endocrine systems in the living body. Moreover, there is a suggestive consideration that the bisphenol A may have influence on aging. In order to investigate the lifespan associated with the bisphenol A, we gave a sin gle subcutaneous injection of bisphenol A to pregnant Wistar rats on gestational day 19 and studied the effects of a relatively low dose of bisphenol A on the offspring. The plasma concentration of thyroxin and gonadal hormone decreased in male and female by perinatal bisphenol A exposure, on the other hand the incidence of mammary tumors increased in female. The bisphenol A may play an important role in both hypogenitalism and hypothyroidism. The experimental study of lifespan is still continuing, the result obtained shows tendency of a slight decrease in male and female. Our finding suggests that the bisphenol A may induce modulation of endocrinologial function and promote aging.
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