| Project/Area Number |
21651047
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Nanomaterials/Nanobioscience
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| Research Institution | Saitama University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,340,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2009: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | ナノ材料創製 / バクテリオロドプシン / 3量体 / ナノ材料 / 超分子 / ナノバイオ / 蛋白質 / RGB / 色覚色素 |
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| Research Abstract |
Human color vision is mediated by three cone receptors in retina. Cone cells contain photosensitive protein molecules which consist of the protein opsin linked to retinal (vitamine A aldehyde), a prosthetic group. The three distinct photoreceptor proteins have absorption maxima(λmax)at 560, 530 and 426 nm respectively. These absobances correspond to the red(R), green(G)and blue(B)regions of the spectrum. The photoexcited cone pigments are degraded to opsins and retinals. These are unstable and unable to apply to photosensitive divices.
Extremely halophilic archaebacteria have photosensitive proteins homologous with rhodopsin. These bacterial rhodopsin-like proteins are not photodegraded and extremely stable. One of the bacterial rhodopsin, bacteriorhodopsin(bR)forms trimer in the cell membrane. The absorption maximum for bR is 560 nm identical to that for the red cone pigment. If the stable chromoproteins withλmax at 530 and 426 nm is able to prepared, it is possible to challenge to make the mixed trimer unit consisting of three distinct chromoproteins with absorbances corresponding to RGB regions. The creation of the artificial proteins with 80-nm blue shifted λmax is successful.
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