| Project/Area Number |
21651098
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Living organism molecular science
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| Research Institution | Kanagawa University |
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Principal Investigator |
ONO Akira 神奈川大学, 工学部, 教授 (10183253)
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| Co-Investigator(Kenkyū-buntansha) |
OKAMOTO Itaru 神奈川大学, 工学部, 特別助教 (40460133)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,400,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2009: ¥1,100,000 (Direct Cost: ¥1,100,000)
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| Keywords | 生物活性分子の設計・合成 / 核酸医薬 / ドラッグデリバリー / プロドラッグ / 生体膜透過 / 生分解性保護法 / DNA合成 / アミダイト法 / dioxolenone保護基 |
|---|
| Research Abstract |
New methods for protecting the phosphordiester in oligonucleotides, with new bio-degradable protection groups, have been investigated. A thymidyl-thymidine with a new dioxolenone based protection group at the phosphordiester linkage was synthesized. By treating the protected thymidyl-thymidine with a esterase from porcine liver(Sigma-Ardrich), the dioxolenone based protecting group was released and a free thymidyl-thymidine was obtained.
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