Development of micelle and vesicle based on amphiphilic compound bearing various sugar moieties and estimation of their cell recognition abilities.
| Project/Area Number |
21655063
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemistry related to living body
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| Research Institution | Wakayama University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2009: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | 核酸 / 蛋白質 / 糖化学 / 自己組織化 / ナノバイオ / ベシクル / 生体認識 / 薬剤送達システム(DDS) / 両親媒性化合物 / ガラクトース / 原子移動重合 / 薬剤送達システム / ミセル |
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| Research Abstract |
The purpose of this study is the development of stable micelle and/or vesicle based on amphiphilic compounds in order to apply them to the capsule for the drug delivery system(DDS). It is well-known that galactose selectively interacts with the cell on the surface of a liver. Thus, the amphiphilic compounds composed of galactose group as a hydrophilic moietry and various lipophilic moietyies were synthesized and the property of their aggregates were investigated. The glycoside bonds were formed on galactose using 2, 2-bis(octadecyloxymethyl)-1-propanol and 2-benzyloxymethyl-2, 2-bis(octadecyl-oxymethyl)-1-ethanol to give compounds 1 and 2, respectively. It was found by using the spectrophotometry and transmission electron microscope(TEM) that the aggregate of compound 1 has the vesicle structure, which includes an aqueous phase inside.
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Report
(4 results)
Research Products
(40 results)
