| Budget Amount *help |
¥3,460,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2009: ¥900,000 (Direct Cost: ¥900,000)
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| Research Abstract |
Fine structures of autophagic isolation membrane induced by amino acid deprivation in mouse embryonic fibroblasts were investigated. By using newly developed fixation protocol, we found a cluster of narrow tubular structures between the endoplasmic reticulum and isolation membranes. Moreover, they corresponded to"omegasome"that has been identified only at light microscopic levels. These findings could promote research of membrane dynamics and associated molecular mechanisms in the biogenesis of autophagic isolation membrane.
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