| Project/Area Number |
21659052
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
General physiology
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,310,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2009: ¥1,700,000 (Direct Cost: ¥1,700,000)
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| Keywords | 甲状腺 / 上皮細胞 / サイログロブリン / 極性培養 / 甲状腺ホルモン / サイログロリン |
|---|
| Research Abstract |
Thyroid hormones are synthesized in the thyroid follicles consist of thyroid epithelial cells. To examine the effects of thyroglobulin, the precursor molecule of thyroid hormones, on the function of thyroid, we established the functional gradient culture system composed of thyroid epithelial cells and endothelial cells. Using this system, we found that thyroglobulin stimulated the secretion of cathepsin K, one of the key enzymes of thyroid hormone synthesis, to the follicular side. This suggests that thyroglobulin directly regulates the thyroid hormone synthesis.
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