| Project/Area Number |
21659059
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | Showa University |
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Principal Investigator |
SHIODA Seiji 昭和大学, 医学部, 教授 (80102375)
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| Co-Investigator(Kenkyū-buntansha) |
KAGEYAMA Haruaki 昭和大学, 医学部, 助教 (00433839)
TAKENOYA Fumiko 星薬科大学, 薬学部, 講師 (30234412)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,070,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2009: ¥1,000,000 (Direct Cost: ¥1,000,000)
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| Keywords | GALP / 摂食調節 / 抗肥満療法 / エネルギー代謝 / ニューロンネットワーク |
|---|
| Research Abstract |
GALP is known as a neuropeptide whish regulates feeding and energy metabolism but there is no reports to use of GALP for obese animals efficiently. In this study, we have established the intranasal infusion method of GALP for animals. We have studied obese animals such as ob/ob, db/db and DIO mice and we got the data that intranasal infusion of GALP was very effective on these animals to loose body weight and food intake. It is suggested that intranasal infusion of GALP is useful for obese people to conquer obesity and life-style related diseases in future.
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