| Project/Area Number |
21659086
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Human pathology
|
|---|
| Research Institution | Tokyo Medical and Dental University |
|---|
Principal Investigator |
YOSHIDA Shoko 東京医科歯科大学, 大学院・保健衛生学研究科, 助教 (20359681)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥2,010,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2009: ¥600,000 (Direct Cost: ¥600,000)
|
|---|
| Keywords | 悪性リンパ腫 / DNAメチル化 / BCL6転座 |
|---|
| Research Abstract |
This study was carried out to examine the DNA methylation status of the BCL6 translocation partner gene, particularly the CpG island within the frequently mutated regions, among the cases with malignant lymphoma to study whether it affects the expression or mutagenesis of the partner gene, and whether it is associated with the subtypes or prognosis of the malignant lymphoma. The present study indicated that the DNA methylation status of CpG islands of the partner genes did not affect the expression or mutagenesis of the genes.
|
