| Project/Area Number |
21659146
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Laboratory medicine
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| Research Institution | University of Fukui |
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Principal Investigator |
UEKI Misuzu 福井大学, 医学部, 助手 (00165656)
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| Co-Investigator(Renkei-kenkyūsha) |
YASUDA Toshihiro 福井大学, 医学部, 教授 (80175645)
IIDA Reiko 福井大学, 医学部, 准教授 (40139788)
KAWAI Yasuyuki 金沢医科大学, 医学部, 准教授 (40324157)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,490,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2009: ¥900,000 (Direct Cost: ¥900,000)
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| Keywords | 心筋虚血 / DNase I / 診断マーカー / SNP / DNase family / 遺伝子型-活性相関 / deoxyribonuclease I / 非ST上昇型急性心筋梗塞 / 不安定狭心症 / 一過性心筋虚血 / deoxyribonuclease I-like 3 / deoxyribonuclease II / 集団調査 / 急性冠症候群 / 低酸素応答 |
|---|
| Research Abstract |
The aim of this study was to evaluate utilization of serum DNase I as a novel diagnostic biomarker of transient myocardial ischemia ;(1) A high diagnostic efficacy of serum DNase I activity levels could be observed in the early phase, even in unstable pectoris or non-ST segment elevation myocardial infarction patients who did not show elevation of conventional cardiac biomarkers. Thus, serum DNase I activity can be a useful biomarkers for the early diagnosis of these diseases inducing a transient myocardial ischemia after the onset of chest pain.(2) A transient elevation of the serum DNase I activity induced by a myocardial ischemia could in partial result from hypoxia-response of DNase I gene.(3) In non-synonymous SNPs of DNase I and I-like 3 genes, specific alleles producing an inactive/low activity-harboring enzyme were found. These alleles might be one of several factors involved in genetic predisposition to autoimmune diseases.
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