Serum DNase I activity can be a useful biomarker for the early diagnosis of transient myocardial ischemia
Project/Area Number |
21659146
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Single-year Grants |
Research Field |
Laboratory medicine
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Research Institution | University of Fukui |
Principal Investigator |
UEKI Misuzu 福井大学, 医学部, 助手 (00165656)
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Co-Investigator(Renkei-kenkyūsha) |
YASUDA Toshihiro 福井大学, 医学部, 教授 (80175645)
IIDA Reiko 福井大学, 医学部, 准教授 (40139788)
KAWAI Yasuyuki 金沢医科大学, 医学部, 准教授 (40324157)
|
Project Period (FY) |
2009 – 2011
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Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥3,490,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2009: ¥900,000 (Direct Cost: ¥900,000)
|
Keywords | 心筋虚血 / DNase I / 診断マーカー / SNP / DNase family / 遺伝子型-活性相関 / deoxyribonuclease I / 非ST上昇型急性心筋梗塞 / 不安定狭心症 / 一過性心筋虚血 / deoxyribonuclease I-like 3 / deoxyribonuclease II / 集団調査 / 急性冠症候群 / 低酸素応答 |
Research Abstract |
The aim of this study was to evaluate utilization of serum DNase I as a novel diagnostic biomarker of transient myocardial ischemia ;(1) A high diagnostic efficacy of serum DNase I activity levels could be observed in the early phase, even in unstable pectoris or non-ST segment elevation myocardial infarction patients who did not show elevation of conventional cardiac biomarkers. Thus, serum DNase I activity can be a useful biomarkers for the early diagnosis of these diseases inducing a transient myocardial ischemia after the onset of chest pain.(2) A transient elevation of the serum DNase I activity induced by a myocardial ischemia could in partial result from hypoxia-response of DNase I gene.(3) In non-synonymous SNPs of DNase I and I-like 3 genes, specific alleles producing an inactive/low activity-harboring enzyme were found. These alleles might be one of several factors involved in genetic predisposition to autoimmune diseases.
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Report
(4 results)
Research Products
(48 results)
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[Journal Article] Functional and genetic survey of all known the SNPs within human deoxyribonuclease I gene in wide-ranging ethnic groups2011
Author(s)
Fujihara J, Ueki M, Yasuda T, Iida R, Soejima M, Koda Y, Kimura-Kataoka K,Kato H, Panduro A, Tongu M, Takeshita H
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Journal Title
DNA and Cell Biol.
Volume: 30(4)
Issue: 4
Pages: 205-217
DOI
Related Report
Peer Reviewed
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[Journal Article] Confirmation that SNPs in the high mobility group-A2 gene (HMGA2) are associated with adult height in the Japanese population ; wide-ranging population survey of height-related SNPs in HMGA22011
Author(s)
Takeshita H, Fujihara J, Soejima M, Koda Y, Kimura-Kataoka K, Ono R, Yuasa I, Iida R, Ueki M, Nagao M, Yasuda T
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Journal Title
Electrophoresis
Volume: 32
Issue: 14
Pages: 1844-1851
DOI
Related Report
Peer Reviewed
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[Journal Article] Identification of the brackish water clam Corbicula japonica (Japanese name, Yamato-shijimi) and pecification of the growing district by PCR-based analysis of mitochondrial DNA2011
Author(s)
Fujihara, J, Yasuda, T, Ueki M, Fujita Y, Nakamura M, Oshiumi C, Hosozawa T, Nabika T, Harada Y, Kobayashi T, Nakajima T, Takeshita H
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Journal Title
Environmental Forensics Journal
Volume: 9
Issue: 2
Pages: 25-31
DOI
Related Report
Peer Reviewed
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[Journal Article] A biochemical and genetic study on all non-synonymous single nucleotide polymorphisms of the gene encoding human deoxyribonuclease I potentially relevant to autoimmunity2010
Author(s)
Yasuda T, Ueki M, Takeshita H, Fujihara J, Kimura-Kataoka K, Iida R, Tsubota E, Soejima M, Koda Y, Kato H, Panduro A
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Journal Title
Int J Biochem Cell Biol.
Volume: 42(7)
Issue: 7
Pages: 1216-1225
DOI
Related Report
Peer Reviewed
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